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Very excited to see this work out today @ScienceMagazine!
Discovering viral proteins that block immune signaling from predicted protein structures🤩
science.org/doi/10.1126/sc…
Huge thanks to the amazing collaborators! 🤗
Linking previous thread on our findings below 👇
Discovering viral proteins that block immune signaling from predicted protein structures🤩
science.org/doi/10.1126/sc…
Huge thanks to the amazing collaborators! 🤗
Linking previous thread on our findings below 👇
📢Preprint out!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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Nitzan Tal retweeted
📢 Preprint out!
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.110…
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.110…
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Nitzan Tal retweeted
It’s out! Read my review with @SorekLab on the nucleotide pool as a central playground in antiviral immunity across humans, bacteria and plants! 🧍♀️🦠🌿
& the diverse ways in which viruses overcome these nucleotide-based immune mechanisms 🗡️
nature.com/articles/s4157…
& the diverse ways in which viruses overcome these nucleotide-based immune mechanisms 🗡️
nature.com/articles/s4157…
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📢Preprint out!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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I was completely in love with this project from day one, and watching it grow was such an incredible experience. 💕
📝 Read more here: tinyurl.com/j4fj9k7f
Huge thanks to everyone who made it happen - especially my brilliant collaborators 👇
I was completely in love with this project from day one, and watching it grow was such an incredible experience. 💕
📝 Read more here: tinyurl.com/j4fj9k7f
Huge thanks to everyone who made it happen - especially my brilliant collaborators 👇
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Special thanks to:
@HadaryRomi, Renee Chang, @IlyaOsterman, Roy Jacobson, @ErezTzvi, @nath_becho,
@dinahoch, Miguel López Rivera, Barak Madhala, @TanaWein, @amitai_gil, the Kranzusch lab, and the incredible @Soreklab that I was so proud to call my home these last few years.🥰
Special thanks to:
@HadaryRomi, Renee Chang, @IlyaOsterman, Roy Jacobson, @ErezTzvi, @nath_becho,
@dinahoch, Miguel López Rivera, Barak Madhala, @TanaWein, @amitai_gil, the Kranzusch lab, and the incredible @Soreklab that I was so proud to call my home these last few years.🥰
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Nitzan Tal retweeted
Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria
We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats @FrancoisRousset & @IlyaOsterman!
science.org/doi/10.1126/sc…
We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase
Congrats @FrancoisRousset & @IlyaOsterman!
science.org/doi/10.1126/sc…
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Nitzan Tal retweeted
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems
Congrats @TanaWein! Thanks Kranzusch lab!
tinyurl.com/CA88DD
CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems
Congrats @TanaWein! Thanks Kranzusch lab!
tinyurl.com/CA88DD
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Nitzan Tal retweeted
Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab
nature.com/articles/s4158…
nature.com/articles/s4158…
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Nitzan Tal retweeted
I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now!
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
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