Romi Hadary retweeted
Happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life
go.bsky.app/redirect?u=htt…
go.bsky.app/redirect?u=htt…
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📢 Preprint out!
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.110…
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.110…
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Remarkably, 65 sponges inhibit ≥1 immune system, and 25 block multiple. They evolved specificity & diversity, a striking example of the phage–bacteria arms race. Sponges appear key for phages, shaping many bacteria–virus interactions, and new families keep being discovered.
Remarkably, 65 sponges inhibit ≥1 immune system, and 25 block multiple. They evolved specificity & diversity, a striking example of the phage–bacteria arms race. Sponges appear key for phages, shaping many bacteria–virus interactions, and new families keep being discovered.
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It was such a fun and inspiring journey 🎉 Huge thanks to @reneechang — it was a pleasure working on this together!
Special thanks to all amazing contributors:
@nath_bechon , @Nitzan_T , @IlyaOsterman , @ErezTzvi , @GarbJeremy , @GilAmitai
It was such a fun and inspiring journey 🎉 Huge thanks to @reneechang — it was a pleasure working on this together!
Special thanks to all amazing contributors:
@nath_bechon , @Nitzan_T , @IlyaOsterman , @ErezTzvi , @GarbJeremy , @GilAmitai
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A beautiful and much-needed review on the role of nucleotides in immunity 💫🧬@dinahoch
It’s out! Read my review with @SorekLab on the nucleotide pool as a central playground in antiviral immunity across humans, bacteria and plants! 🧍♀️🦠🌿
& the diverse ways in which viruses overcome these nucleotide-based immune mechanisms 🗡️
nature.com/articles/s4157…
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Amazing work led by @Nitzan_T – so happy to see it out! 🧬💫
📢Preprint out!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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