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It’s out! Read my review with @SorekLab on the nucleotide pool as a central playground in antiviral immunity across humans, bacteria and plants! 🧍‍♀️🦠🌿
& the diverse ways in which viruses overcome these nucleotide-based immune mechanisms 🗡️
nature.com/articles/s4157…
& the diverse ways in which viruses overcome these nucleotide-based immune mechanisms 🗡️
nature.com/articles/s4157…
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Dina Hochhauser retweeted
📢Preprint out!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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Fantastic results from the very talented @HadaryRomi et al. on viral counter-defence sponges!! 🧽đź¦
📢 Preprint out!
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.110…
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Dina Hochhauser retweeted
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.
Huge congratulations to @ugobananas_uuu @Zhangzhiyi58692 and @TCTodeschini, and to all our collaborators.
shorturl.at/l0ayB
Huge congratulations to @ugobananas_uuu @Zhangzhiyi58692 and @TCTodeschini, and to all our collaborators.
shorturl.at/l0ayB
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It was such a pleasure to work on this wonderful project with the talented @Nitzan_T !
📢Preprint out!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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Dina Hochhauser retweeted
Thrilled to introduce AlphaGenome, our new DNA sequence model now available via our AlphaGenome API. Really excited to see how the scientific community uses AlphaGenome’s predictions to understand genome function, drive biological discoveries, develop new treatments, and more...
Introducing AlphaGenome: an AI model to help scientists better understand our DNA – the instruction manual for life 🧬
Researchers can now quickly predict what impact genetic changes could have - helping to generate new hypotheses and drive biological discoveries. ↓
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Dina Hochhauser retweeted
Out now in @MolecularCell: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA
cell.com/molecular-cell…
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
A 🧵
cell.com/molecular-cell…
Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?
A 🧵
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Dina Hochhauser retweeted
White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the @amazeld lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…
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Dina Hochhauser retweeted
Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork!
nature.com/articles/s4158…
nature.com/articles/s4158…
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Dina Hochhauser retweeted
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery biorxiv.org/content/10.110… #biorxiv_micrbio
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Dina Hochhauser retweeted
Fantastic new preprint of Vaughn Cooper's lab @vscooper - filamentous phages can get cancer and it's contagious. 🔥👇🏼
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
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Dina Hochhauser retweeted
A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins biorxiv.org/content/10.110… #biorxiv_micrbio
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Dina Hochhauser retweeted
If you are interested in phage satellites, we hope you'll enjoy this. Fun collaboration with the Rocha, Seed, Bikard, and Chen labs!
nature.com/articles/s4157…
nature.com/articles/s4157…
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Dina Hochhauser retweeted
The sequel to our DRT2 story is here, and this one is once again full of surprises! This time around, the @SternbergLab teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: biorxiv.org/content/10.110…
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Dina Hochhauser retweeted
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 nature.com/articles/s4158…
🧵👇
🔗 nature.com/articles/s4158…
🧵👇
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Dina Hochhauser retweeted
My lab’s first preprint!
We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages.
biorxiv.org/content/10.110…
1/10
We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages.
biorxiv.org/content/10.110…
1/10
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Dina Hochhauser retweeted
Happy to share our new preprint describing prophage encoded anti-phage defense system,TERi, that targets the terminase complex of invading phages to inhibit DNA packaging. The system also encode self immunity proteins that protect the prophage.
biorxiv.org/content/biorxi…
biorxiv.org/content/biorxi…
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Dina Hochhauser retweeted
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/sc…
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Dina Hochhauser retweeted
Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system biorxiv.org/content/10.110… #biorxiv_micrbio
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Dina Hochhauser retweeted
It is finally out!
Muntathar Al-Shimary, Doudna Lab, @bradyfcress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)!
Check out the final paper in @NatureMicrobiol
nature.com/articles/s4156…
Muntathar Al-Shimary, Doudna Lab, @bradyfcress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)!
Check out the final paper in @NatureMicrobiol
nature.com/articles/s4156…
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