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I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now!
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
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Erez Tzvi Yirmiya retweeted
🎉Excited to share our new preprint!
TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
biorxiv.org/content/10.648…
TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
biorxiv.org/content/10.648…
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Honored to be part of the 2026 cohort and looking forward to the journey ahead! @SchmidtFellows
We are thrilled to introduce our 2026 Schmidt Science Fellows — thirty-two incredible scientists set to embark on the next step of their interdisciplinary journey with our support. schmidtsciencefellows.org/news/the-2026-… @schmidtsciences
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Happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life
go.bsky.app/redirect?u=htt…
go.bsky.app/redirect?u=htt…
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We expanded the landscape of TIR immune signaling in microbes and revealed unexpected connections with plant and animal immunity. Many Thoeris effectors and signals remain uncharacterized and uncovering them could once again reshape our understanding of immunity across life🦠🌱🧍♀️
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Huge thanks to co-first author Azita Leavitt - as always, it was so fun and fruitful to work together! Special thanks also to @bhurieva, Alla H. Falkovich, @nath_bechon, François Rousset, @IlyaOsterman, and @SorekLab!
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Congrats @HadaryRomi @reneechang for dissecting the functional diversity of ALL Sponges! 🧽
📢 Preprint out!
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.
Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
biorxiv.org/content/10.110…
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Amazing work identifying novel immune inhibitors based on structural and genomic traits.
Congrats Nitzan et al!!
Congrats Nitzan et al!!
📢Preprint out!
Excited to share my final work from the @SorekLab!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
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