Pinned Tweet
I am excited to share that I will be starting as a tenure track Assistant Professor in @CoulterBME at @GeorgiaTech in the upcoming year. I am very grateful of the unwavering support of my postdoctoral mentor, @SynBioGaoLab , and my PhD supervisor, Michael Sefton.
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Alex Vlahos (he/him) retweeted
Coutler BME’s Alexander Vlahos received a 5-year @BreakthroughT1D grant to engineer cells that can sense stress and improve survival after islet transplantation beneath the skin – which may lead to better treatment for type 1 #diabetes.
Learn more: bme.gatech.edu/news/new-resea…
Learn more: bme.gatech.edu/news/new-resea…
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Alex Vlahos (he/him) retweeted
Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs.
🧵👇
🧵👇
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Alex Vlahos (he/him) retweeted
They said you couldn't get RNA-seq results in 3 days.
For $50.
They were wrong.
(The turtleneck is strictly for aesthetic purposes. The science is real.) 🦖🧬
For $50.
They were wrong.
(The turtleneck is strictly for aesthetic purposes. The science is real.) 🦖🧬
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Alex Vlahos (he/him) retweeted
My postdoc work is now on bioRxiv!
We combined engineered bacteria with hydrogels to create implantable living materials.
These living materials safely confine microbes while enabling them to sense disease and release drugs on demand.
🔗 biorxiv.org/content/10.110…
We combined engineered bacteria with hydrogels to create implantable living materials.
These living materials safely confine microbes while enabling them to sense disease and release drugs on demand.
🔗 biorxiv.org/content/10.110…
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Alex Vlahos (he/him) retweeted
The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science.
Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving 4–22% success rates with efficient experimental validation.
Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving 4–22% success rates with efficient experimental validation.
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Alex Vlahos (he/him) retweeted
Have you always wanted to take a protein from its native context and make it work elsewhere? Our novel sampler computationally “cytosolize” a secreted enzyme while maintaining its structure, generalizable to other multi-objective guided generation tasks biorxiv.org/content/10.110…
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Alex Vlahos (he/him) retweeted
We're hiring @kemijski !
We aim to translate technologies of synthetic biology toward therapeutic applications, using both protein and RNA-based strategies. PhDs or MSc excited about #syntheticbiology #biotech #proteindesign #RNAdesign are invited to inquire and apply.
Pls RT🔁
We aim to translate technologies of synthetic biology toward therapeutic applications, using both protein and RNA-based strategies. PhDs or MSc excited about #syntheticbiology #biotech #proteindesign #RNAdesign are invited to inquire and apply.
Pls RT🔁
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Alex Vlahos (he/him) retweeted
I am thrilled to announce that I am launching my lab at the Salk Institute in September! The Blum lab will study the physiological effects of plant-derived molecules, with a particular focus on the mammalian immune system.
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Alex Vlahos (he/him) retweeted
🚨 New Preprint 🚨
A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
How can we tune JAK/STAT signaling to create better immune cell therapies?
doi.org/10.1101/2025.0…
A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
How can we tune JAK/STAT signaling to create better immune cell therapies?
doi.org/10.1101/2025.0…
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Alex Vlahos (he/him) retweeted
The machine-guided humanization paper is out after peer review! doi.org/10.1016/j.cels… Key contributions from current and previous international students on visas, representing 5+ countries.
So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…
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Alex Vlahos (he/him) retweeted
Excited to share our latest collaboration with Quan Yuan's lab at NIH:
pnas.org/doi/10.1073/pn…
pnas.org/doi/10.1073/pn…
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Very few instances I read a paper and go wow, but this one takes the cake. Congrats to @ElowitzLab on this elegant work.
Engineered protein circuits for cancer therapy biorxiv.org/content/10.110… #biorxiv_synbio
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Alex Vlahos (he/him) retweeted
🎉 Congratulations to Xiaojing Gao, winner of the 2025 BioInnovation Institute & Science Prize for Innovation for his work developing an innovative programmable RNA sensor and molecular tools to improve mRNA vector therapeutics.
Learn more: scim.ag/4hYXSDI
Learn more: scim.ag/4hYXSDI
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Alex Vlahos (he/him) retweeted
LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.
Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.
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Alex Vlahos (he/him) retweeted
What controls the viability of encapsulated cells in injectable hydrogels?
Out today in @BioMaterSci, our new paper uses rheological tools to show that yielding speed affects viability independently of stiffness! Tweetorial below: pubs.rsc.org/en/content/art…
Out today in @BioMaterSci, our new paper uses rheological tools to show that yielding speed affects viability independently of stiffness! Tweetorial below: pubs.rsc.org/en/content/art…
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Alex Vlahos (he/him) retweeted
So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…
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Happy to have contributed to this awesome project spearheaded by two talented grad students @carlosaaldrete1 and @cnnrcall
It's published! rdcu.be/d6kVt
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Alex Vlahos (he/him) retweeted
We're recruiting a technician to help with our work on neurons! 🧠 Great opportunity to work with @di_wu_ and other awesome scientists @Caltech. Please RT.
Job Opening!
The Shapiro Lab at Caltech is looking for a Research Technician to accelerate our neuro🧠 efforts. Join us! Please RT.
Apply here: tinyurl.com/neurotechnician
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Alex Vlahos (he/him) retweeted
embopress.org/doi/full/10.10…
@AdamArkinLab
Part 1 of 2 of postdoc work. High-throughput protein identification method with lots of potential. protocols.io, FigShare, and Github available. Addgene plasmids will be release soon! Hope it is helpful to folks!
@AdamArkinLab
Part 1 of 2 of postdoc work. High-throughput protein identification method with lots of potential. protocols.io, FigShare, and Github available. Addgene plasmids will be release soon! Hope it is helpful to folks!
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