Pinned Tweet
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.648…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially ion of cancers, infections, and autoimmunity. (1/11)
biorxiv.org/content/10.648…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially ion of cancers, infections, and autoimmunity. (1/11)
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Kyle G Daniels retweeted
11/4/2026
Excited to share our new Nature paper “In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs”. Led by Liqun, with Paul, Kaiyuan, Ariel. Also Tx to support from lab members and Markus, Stephen and Nidhi’s groups. Kudos team!
nature.com/articles/s4158…
Excited to share our new Nature paper “In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs”. Led by Liqun, with Paul, Kaiyuan, Ariel. Also Tx to support from lab members and Markus, Stephen and Nidhi’s groups. Kudos team!
nature.com/articles/s4158…
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Kyle G Daniels retweeted
Excited to share that our MYC mutagenesis paper is now online at @CellCellPress! Free access link through Dec 24 authors.elsevier.com/a/1o316L7PXy4lc. Special thanks to our handling editor Jude @JudeNicho and the reviewers for their support and feedback throughout the process!
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element biorxiv.org/content/10.648…
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Kyle G Daniels retweeted
Membrane protein folding and assembly requires a growing number of ER membrane-bound chaperones.
In my lab’s first paper now out @nsmb we show that the EMC forms a supercomplex with the multipass translocon and #ribosome to fold and assemble nascent #calcium channels.@StanfordMed
In my lab’s first paper now out @nsmb we show that the EMC forms a supercomplex with the multipass translocon and #ribosome to fold and assemble nascent #calcium channels.@StanfordMed
New online! EMC chaperone activity is required for cotranslational calcium channel assembly dlvr.it/TW6t7F
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Kyle G Daniels retweeted
What drives T-DNA integration? We couldn’t get a convincing answer with existing tools, so we built one!
Our new preprint introduces a synthetic biology approach to tracking T-DNA delivery and integration in plants 🌱 biorxiv.org/content/10.648…
Our new preprint introduces a synthetic biology approach to tracking T-DNA delivery and integration in plants 🌱 biorxiv.org/content/10.648…
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Kyle G Daniels retweeted
We can do better than lifelong treatment that prolongs “waiting-to-progress time.” Thrilled to work together toward revolutionary paradigms of cancer treatment with, hopefully, curative potential. Thank you all so much for the opportunity to show our work at @CUCancerCenter!
Watch replay of CAR T Cells to Eradicate Oncogene Driven Lung Cancer w/ @@kyleconcannonMD here: youtube.com/watch?v=30skcF…
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Kyle G Daniels retweeted
Interested in applying to Stanford Genetics PhD program? Join this informational zoom meeting with our department chair (Lars Steinmetz) and current Genetics grad students:
When: Thursday November 5
Time: 11 am-12 pm pacific time
Zoom link: stanford.zoom.us/j/98116204859?…
Password: 535381
When: Thursday November 5
Time: 11 am-12 pm pacific time
Zoom link: stanford.zoom.us/j/98116204859?…
Password: 535381
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Kyle G Daniels retweeted
Sharing one of my lectures - "Multiplex base editing in HSCs couples disease correction with lineage amplification": youtu.be/d3fx8AYT8jk?si…
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Kyle G Daniels retweeted
Brain-sensing synNotch–CAR T cells exhibit efficacy against preclinical models of diffuse midline glioma, outperforming conventional CAR T cells
science.org/doi/10.1126/sc… @ScienceTM @UCSF
science.org/doi/10.1126/sc… @ScienceTM @UCSF
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Kyle G Daniels retweeted
CAR-NK cells delay HIV rebound and reshape HIV reservoir composition @NatureComms
nature.com/articles/s4146… @UCLA
nature.com/articles/s4146… @UCLA
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Kyle G Daniels retweeted
I captured this video in my lab to show the power of medicines called T-cell engagers.
Left: T cells move in and out of a cancer tumoroid, largely ignoring it.
Right: Add a T-cell engager, and the T cells attack. Once they recognize their targets, they tear through the tumor.
Left: T cells move in and out of a cancer tumoroid, largely ignoring it.
Right: Add a T-cell engager, and the T cells attack. Once they recognize their targets, they tear through the tumor.
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Kyle G Daniels retweeted
PSA: get your flu shot now if you haven't already
Using last year's flu trends as a template, from today we expect infection rates to double every 1.5 weeks, peaking ~2 months from now.
After vax, immunity takes 1.5 weeks to kick in, peaks at 1-2 months, decays after 3 months.
Using last year's flu trends as a template, from today we expect infection rates to double every 1.5 weeks, peaking ~2 months from now.
After vax, immunity takes 1.5 weeks to kick in, peaks at 1-2 months, decays after 3 months.
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Kyle G Daniels retweeted
Pleased to share my lab’s new manuscript integrating genomics, drug development, cell biology, and mouse modeling to comprehensively evaluate the cyclin-dependent kinase CDK11 as a drug target in cancer.
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Kyle G Daniels retweeted
Check out this exciting synthetic biology opportunity — designing multicellular circuits at the Allen Institute for Cell Science.
alleninstitute.org/careers/jobs?j…
alleninstitute.org/careers/jobs?j…
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Kyle G Daniels retweeted
We’re excited to share our new perspective in @MolecularCell on designing programmable biological behavior! (1/3)
doi.org/10.1016/j.molc…
doi.org/10.1016/j.molc…
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Kyle G Daniels retweeted
As an Editor, in past ~6mo, we are receiving an avalanche of unsolicited review articles (“scoping” “systematic”, narrative, NOS) on topics and ?s NO ONE EVER has asked and clearly with heavy AI lift. Even the cover letters all read the same…alarming and sad. #publishing
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Kyle G Daniels retweeted
1. COMBINATORIAL STOICHIOMETRY: Regulators do not act alone, there is redundancy, competition, synergy & feedback. Knocking them down one by one is insufficient to learn the spectrum of regulatory effects (which is essential to generalize). 2/
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Kyle G Daniels retweeted
The Keedy Lab at the CUNY ASRC in NYC is looking for a postdoc! Our lab uses avant-garde structural biology experiments and computational analyses to reveal conformational ensembles that underlie biological function. See attached flyer and keedylab.org. Please share!
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Kyle G Daniels retweeted
Congratulations to @DanaFarber’s @nickpolizzi_ and @XinGu0317 who have received New Innovator Awards from the @NIH High-Risk, High-Reward Research program which supports early career investigators pursuing highly innovative research with potential for broad impact on biomedical @DFCI_CancerBio
Read more: bit.ly/4hKLs46
Read more: bit.ly/4hKLs46
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Kyle G Daniels retweeted
Exciting news! Our team was selected to receive the @NIH Director's Pioneer Award!
Our project asks: can we make a tool to perturb & map proteome function at scale, to do “do for proteins what CRISPR has done for genes"?
Our project asks: can we make a tool to perturb & map proteome function at scale, to do “do for proteins what CRISPR has done for genes"?
The NIH Director’s High-Risk, High-Reward Research Awards empower innovative scientists redefining the limits of biomedical and behavioral research.
Meet the 2026 recipients of the NIH Director’s Pioneer, New Innovator, and Transformative Research Awards and discover the they’re pursuing: go.nih.gov/BxJzhAG
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Kyle G Daniels retweeted
We're hosting a small event to discuss the latest advances in AI and biology this Friday evening, featuring @arcinstitute researchers and others. Apply if interested! forms.gle/1fh1GpHrimqu1H…
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