New work links synovial inflammation in #osteoarthritis to a signaling axis involving CD74 and ENO2 that reprograms macrophages into an inflammatory and metabolically active state—but shows these cells can be targeted to treat the disease in mice. scim.ag/4A4r7yx

By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. scim.ag/4yyYZSP

A new bispecific antibody targets both #CCR8 to deplete regulatory T cells and CD3 to revitalize the broader anti-tumor T cell armada. It combated multiple tumor types and potentiated immunotherapy in mice while being safe in large animals. @genentech scim.ag/4e4t05H

In a unique human challenge study, researchers interrogate how preexisting immunity and antibodies against the four serotypes of #dengue influence viremia, T cell responses, and immune activation in a safe and controlled setting. @CamilaOdio @NIH scim.ag/3W4jxVS

A unique human challenge study illuminates how dengue immunity shapes the nature of repeated infections, researchers identify a targetable molecular driver of skin inflammation in psoriasis, and more this week in #ScienceTranslationalMedicine. scim.ag/4zgXqds

By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. scim.ag/4yyYZSP

Researchers present a novel agent for near-infrared fluorescent imaging of #LungCancer that binds to ChoK-alpha, which can highlight close tumor margins and spot easy-to-miss lesions during surgical resection of tumors in canines. @PennRadiology scim.ag/4hVPF6z

By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896 scim.ag/4zzZLzU

An analysis of trial data from stem cell transplant recipients shows how immune suppression with either #cyclophosphamide or #tacrolimus shapes T cell reconstitution—and has opposing effects on the risk of #GVHD or infection post-transplant. @MSK_DeptOfMed scim.ag/4k8Is4p

By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. scim.ag/4yyYZSP

A new antifungal drug architecture combats infections in mice without the usual toxicity, a fluorescent imaging agent could enable more pinpointed removal of lung cancer tumors, and more in this week's new issue of #ScienceTranslationalMedicine. scim.ag/4z2AYEQ

AI is transforming the discovery and design of #antibiotics but requires concurrent progress in data standards, validation pipelines, and regulation to reach patients, argues a new Viewpoint. @delafuentelab @Hanqun_CAO @MIT_IMES scim.ag/4z09IH9

In a new Editorial, researchers sound the alarm against the rising tide of rifampicin-resistant #tuberculosis and urge the need for an effective vaccine and control measures that integrate genomics and social interventions. @Unesp_Oficial @facfarmaciaUL scim.ag/47YQ7Lo

A new Viewpoint discusses how integrating modernized commercial models, genomic surveillance, streamlined trial design, advances in #AI, and other innovations can tackle the dangers of #AntibioticResistance. @GSK scim.ag/4zEtNm7

A small molecule therapy for #Alzheimers disease that activates #TREM2 in #microglia boosts the breakdown of amyloid-beta in neurons and mice and is well-tolerated in healthy individuals and patients, according to results from a phase 1 trial. @sanofi scim.ag/4jYmDEv

A new Editorial stresses the importance of the simple but fundamental concept of prevention in combating antimicrobial resistance, and calls for more support for IPC and WASH in low- and middle-income countries to reduce antibiotic demand. @EdinUniUsher scim.ag/3Uv4kfY

With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite's lifespan. scim.ag/4yvGu2q

Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @moderna_tx scim.ag/47Vt445

By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896 scim.ag/4zzZLzU

The new issue of #ScienceTranslationalMedicine is out!

A large clinical study in China uncovers "clocks" of human aging that may predict chronic disease, a new mRNA antibody therapy could better tackle ever-evolving SARS-CoV-2 variants, and more. scim.ag/4yjVa3G