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We deimmunized a clinical CD19 CAR binder with experimentally detected HLA-I epitope depletion while retaining tumor killing, and rescued a secreted protease to function in the cytosol.
Both done with one unified design framework: ProVADA.
How it works and what we tested 🧵 (1/11)
Both done with one unified design framework: ProVADA.
How it works and what we tested 🧵 (1/11)
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Super cool work! Please check it out.
We deimmunized a clinical CD19 CAR binder with experimentally detected HLA-I epitope depletion while retaining tumor killing, and rescued a secreted protease to function in the cytosol.
Both done with one unified design framework: ProVADA.
How it works and what we tested 🧵 (1/11)
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I am thrilled to announce that I am launching my lab at the Salk Institute in September! The Blum lab will study the physiological effects of plant-derived molecules, with a particular focus on the mammalian immune system.
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LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.
Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.
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Thank you so much @bioe_stanford @inflectionaward !!! 🌱
Stanford BioE PhD student Bella Archibald named Top 30 Young Scientists working on breakthrough solutions to climate change 🌍🛠️🌿 Honored by @inflectionaward for her impact. Congrats, @bella_arch 🙌🏼 bioengineering.stanford.edu/news/stanford-…
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It's published! rdcu.be/d6kVt
When we talk about viral protease-based circuits, people wonder: "if it's meant as therapeutics, are you concerned about immunogenicity"? Now, in hDIRECT, we established control of cytokines using a human protease and its FDA-approved inhibitor: doi.org/10.1101/2024.0…
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Next stop for the Heilshorn Lab is the Bioengineering & Translational Medicine Conference and AIChE Annual Meeting in San Diego! We are thrilled to be sharing our research at these 2 colocated events. Come say hi! 🌴 #AIChE2024 @ChEnected
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Apparently the doi link isn't working yet. Here's the BioRxiv: biorxiv.org/content/10.110…
Synbio loves IFFLs, including recent cool works from @ElowitzLab and @GallowayLabMIT. We implemented protease-based IFFLs with unique features for dosage control, and demonstrated them against Rai1 that underlies conditions like SMS and PTLS doi.org/10.1101/2024.1…
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#TraineeSpotlight: Lexie is a Chemical Engineering PhD Candidate. Her research focuses on developing novel aptamers via modified SELEX schemes and characterizing them for biosensing applications. In her free time, @LexieM_Adams enjoys traveling, running, and wine tasting.
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I am excited to share that I will be starting as a tenure track Assistant Professor in @CoulterBME at @GeorgiaTech in the upcoming year. I am very grateful of the unwavering support of my postdoctoral mentor, @SynBioGaoLab , and my PhD supervisor, Michael Sefton.
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Congratulations to Paolo Ramos on successfully defending his Ph.D. thesis "Engineering the Structure and Electrical Behavior of Carbon Black Suspensions." Paolo will be starting his new job at L'Oréal in New Jersey. Best wishes for continued success in this new chapter, Paolo!😊
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Excited to be at @ChEnected annual meeting this week! Catch me at the MTFC poster session tomorrow 1-3pm (poster 335) and in Monday's Faculty candidate oral session (1:42 pm in Celebration 15). Excited to share my vision on using synthetic biology to create smart therapeutics!
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Curious about synbio + tissue engineering (and much more)? Check out Alex's poster and talks at AICHE!
Excited to be at @ChEnected annual meeting this week! Catch me at the MTFC poster session tomorrow 1-3pm (poster 335) and in Monday's Faculty candidate oral session (1:42 pm in Celebration 15). Excited to share my vision on using synthetic biology to create smart therapeutics!
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Excited to share a new preprint from @SynBioGaoLab at @StanfordEng on Compact Programmable Control of Protein Secretion in Mammalian Cells biorxiv.org/content/10.110…
There is a need to ensure that the #synbio tools we develop can fit within pre-existing vectors for delivery!
There is a need to ensure that the #synbio tools we develop can fit within pre-existing vectors for delivery!
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Pls RT: Do you wanna meet synbio friends old and new? Do you always wonder what mammalian synbio is about? Do you just need an excuse to visit San Jose in summer? The 10th mSBW is open for registration mammalian-synbio.org/2023! Abstract deadline coming up soon too.
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Super excited to share our first pre-print of 2023!
CAR T cells can't be dynamically tuned in vivo, creating safety and resistance issues. To overcome this, we developed a valency controlled receptor (VCR) that uses drugs to modulate CAR T cell activity. 👇🧵@Stanford_ChEMH
CAR T cells can't be dynamically tuned in vivo, creating safety and resistance issues. To overcome this, we developed a valency controlled receptor (VCR) that uses drugs to modulate CAR T cell activity. 👇🧵@Stanford_ChEMH
Programmable Drug Control of Receptor Valency Modulates the Potency of Cell Therapeutics biorxiv.org/cgi/content/sh… #bioRxiv
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Look at all this beautiful free speech!
Ryan Mac of The New York Times (@RMac18) has also been banned.
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I'm at #AIChE2022! Come see my talk and learn how to design more effective biomaterials. Looking forward to hearing other great talks and interesting discussions this week.
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Specific RNAs are detected in live cells by harnessing endogenous ADAR enzymes go.nature.com/3Cxx4sO
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Also forgot to push my new website to the Twitter world! Learn more about my research at alexandervlahos.com. Always happy to chat about any potential opportunities or science in general!
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