Pessimism can kill you. But that's not the full story.
Finland followed 2,267 adults for 11 years. The most pessimistic had 2.2 times the risk of dying from coronary heart disease as the least pessimistic.
But optimism did nothing. No protective effect at all.
Which means that ositivity.
It is dropping the expectation that everything will go wrong.
Finland followed 2,267 adults for 11 years. The most pessimistic had 2.2 times the risk of dying from coronary heart disease as the least pessimistic.
But optimism did nothing. No protective effect at all.
Which means that ositivity.
It is dropping the expectation that everything will go wrong.
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@MeTheAngryCat @TannerBuilds I actually think it looks more like the original. It's probably a little lighter but the lighting makes a difference for sure.
To the point where I was pretty sure it's literally the same blue (super common color there).
To the point where I was pretty sure it's literally the same blue (super common color there).
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@bradsmith A bit north but I go down there sometimes. Wouldn't be anywhere else 😊
The whole area is so amazing for boating.
The whole area is so amazing for boating.
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These numbers should embarrass the whole medical establishment.
Microsoft built a panel of AI agents that argue about your case, order tests one at a time, and settle on a diagnosis.
On 304 NEJM cases so hard they get presented at conferences, the panel hit 83%. Human cases: 80% vs 47%.
Half the testing cost. And it lifted weak models the most, which tells you the magic is in the process, not the model.
The future of medicine is AI.
Microsoft built a panel of AI agents that argue about your case, order tests one at a time, and settle on a diagnosis.
On 304 NEJM cases so hard they get presented at conferences, the panel hit 83%. Human cases: 80% vs 47%.
Half the testing cost. And it lifted weak models the most, which tells you the magic is in the process, not the model.
The future of medicine is AI.
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"Vacation" is a funny word.
We have normalized it so completely that nobody stops to ask what it actually is.
A quota of trips per year, dosed out like a vitamin you are deficient in. For what? Why? Who decided that going somewhere is a requirement of life?
And to be clear, Time off is not the issue. I am talking about the vacation itself. The production.
We have normalized it so completely that nobody stops to ask what it actually is.
A quota of trips per year, dosed out like a vitamin you are deficient in. For what? Why? Who decided that going somewhere is a requirement of life?
And to be clear, Time off is not the issue. I am talking about the vacation itself. The production.
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I have posted this before - so it was actually possible you have seen it.
At our Sam's - the produce is on par and usually better than what we could get at Costco (which was largely disappointing, surprisingly) - and Sam's has a better selection of grass fed meats and organic chicken. (Costco essentially-grass fed meat is the same quality as Costco as well.
Plus Sam's has a much larger overall selection, scan and go so no lines, etc.
Costco quality and pricing is a bit of a myth.
At our Sam's - the produce is on par and usually better than what we could get at Costco (which was largely disappointing, surprisingly) - and Sam's has a better selection of grass fed meats and organic chicken. (Costco essentially-grass fed meat is the same quality as Costco as well.
Plus Sam's has a much larger overall selection, scan and go so no lines, etc.
Costco quality and pricing is a bit of a myth.
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Way too much counterfeit supplements on Amazon. But you like the pricing...
What I prefer about Fullscript is the direct to brand sourcing model - so you know what you are getting.
My Fullscript is open to everyone with exclusive discounts...
us.fullscript.com/s/reallyoptimi…
What I prefer about Fullscript is the direct to brand sourcing model - so you know what you are getting.
My Fullscript is open to everyone with exclusive discounts...
us.fullscript.com/s/reallyoptimi…
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Fantastic breakdown by @nicknorwitz
Want to better understand the emerging science around extreme longevity and how humans are rapidly advancing towards it?
youtu.be/h3Sav_SBYj4
Want to better understand the emerging science around extreme longevity and how humans are rapidly advancing towards it?
youtu.be/h3Sav_SBYj4
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This is the classic Mediterranean diet.
I am a fan of Mediterranean style of eating, but a more modern version without the excessive carbs.
This pyramid here would be a disaster for most people in terms of compliance.
I am a fan of Mediterranean style of eating, but a more modern version without the excessive carbs.
This pyramid here would be a disaster for most people in terms of compliance.
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24 minutes for strength and cardio this morning.
That's it.
Minimum *effective* dose is not high and it's easy to achieve with the right protocol.
Get it done and then stay active with functional movement/non exercise activity the rest of the day.
That's all it takes.
That's it.
Minimum *effective* dose is not high and it's easy to achieve with the right protocol.
Get it done and then stay active with functional movement/non exercise activity the rest of the day.
That's all it takes.
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Tesla robotaxi in Austin now runs 6am to midnight. Fleet went from 45 to 300+ Cybercabs in a month. The only thing standing between this and 24/7 is the cars can't reliably see small animals in the dark. The future is being held up by raccoons.
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It's that time of year again...
For anyone who wants to break free from insurance insanity and save a fortune, this is the time to do it.
reallyoptimized.substack.com/p/why-im-skipp…
For anyone who wants to break free from insurance insanity and save a fortune, this is the time to do it.
reallyoptimized.substack.com/p/why-im-skipp…
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Amazon is quietly disrupting the grocery space again - with no tipping!
The latest move is replacing the standalone "Fresh" with "Grocery" - which routes through Prime for fast, same day and entirely free delivery. Not even a tipping option.
Cheaper prices than your grocery and delivered in a matter of hours to your front door entirely free.
The grocery delivery space heating up more and more, and Amazon is playing to win.
I almost never shop in store anymore. Why would I?
The latest move is replacing the standalone "Fresh" with "Grocery" - which routes through Prime for fast, same day and entirely free delivery. Not even a tipping option.
Cheaper prices than your grocery and delivered in a matter of hours to your front door entirely free.
The grocery delivery space heating up more and more, and Amazon is playing to win.
I almost never shop in store anymore. Why would I?
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Here is the advanced move:
Do good things without your name on them. Help a coworker and tell no one. Give without the announcement post. The moment you need credit, you have turned generosity back into self promotion.
The people who understand this stop keeping score. They y, they are the happiest people in every room.
The self was never the project. It was the obstacle. And the door out was never inward. It was outward, toward other people, the whole time.
Get the full lesson:
reallyoptimized.substack.com/p/stop-working…
Do good things without your name on them. Help a coworker and tell no one. Give without the announcement post. The moment you need credit, you have turned generosity back into self promotion.
The people who understand this stop keeping score. They y, they are the happiest people in every room.
The self was never the project. It was the obstacle. And the door out was never inward. It was outward, toward other people, the whole time.
Get the full lesson:
reallyoptimized.substack.com/p/stop-working…
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@morganlinton Cursor has had Agent Review for awhile. What makes this unique or better with Claude Code?
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OpenEvidence partnered with Johns Hopkins to redesign medical school.
AI handles the knowledge, doctors keep the judgment.
Yeah, right.
That is what they said about the knowledge part years ago.
Knowledge was the doctor's moat, then it became free.
Judgment is next. Hey, care that we love so much, right?
Judgment is pattern recognition plus context, and context is more data.
The question is not whether doctors keep the judgment, it's how long until they don't.
Soon enough, human judgment will be malpractice.
AI handles the knowledge, doctors keep the judgment.
Yeah, right.
That is what they said about the knowledge part years ago.
Knowledge was the doctor's moat, then it became free.
Judgment is next. Hey, care that we love so much, right?
Judgment is pattern recognition plus context, and context is more data.
The question is not whether doctors keep the judgment, it's how long until they don't.
Soon enough, human judgment will be malpractice.
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Argon is getting a workout.
And absolutely crushing the tasks.
Significant security audits and fixes (old programmers work - glad they are fired)...
Absolutely not a single error or issue with the updates so far, which is uncommon with updates this size and complexity.
And absolutely crushing the tasks.
Significant security audits and fixes (old programmers work - glad they are fired)...
Absolutely not a single error or issue with the updates so far, which is uncommon with updates this size and complexity.
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Cursor on top of it.
Giving this a go shortly. And all you need is an @cursor_ai subscription to get this kind of access.
Giving this a go shortly. And all you need is an @cursor_ai subscription to get this kind of access.
Gemini 4 Argon is here.
It’s available globally today for developers and enterprises in the paid tier of the Gemini API and the Gemini platform, for Ultra subscribers in Google Antigravity, and Ultra and Pro subscribers in the Gemini app and Search.
Hope you all enjoy it!
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194 year old tortoise.
Its mitochondrial gene switches stayed orderly for two centuries.
272 promoters kept clean, mostly around mitochondria and DNA repair.
We do not know the how, yet.
But the blueprint exists on paper today.
And AI is how we turn blueprints into biology.
st.
Exponentially.
We will live for centuries.
Its mitochondrial gene switches stayed orderly for two centuries.
272 promoters kept clean, mostly around mitochondria and DNA repair.
We do not know the how, yet.
But the blueprint exists on paper today.
And AI is how we turn blueprints into biology.
st.
Exponentially.
We will live for centuries.
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The @MiamiDolphins should sign @TimTebow for the rest of the season.
Why the hell not.
Tim would fill the stadium and probably find a way to win some games, too.
Why the hell not.
Tim would fill the stadium and probably find a way to win some games, too.
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This is obviously a bit of a gimmick in terms of actual aging and pace of aging.
But it is useful to see where you stack up against your age group.
This seems to be about as good as you can get on the Eight Sleep metrics.
Be a professional sleeper.
It'll change your life.
But it is useful to see where you stack up against your age group.
This seems to be about as good as you can get on the Eight Sleep metrics.
Be a professional sleeper.
It'll change your life.
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There is nothing healthy about this type of entertainment.
It's toxic mind poison.
These sensory impressions are food for the consciousness.
What you feed your mind matters, a lot.
When the sense doors are open to violent agitation, the mind gets bruised.
It's toxic mind poison.
These sensory impressions are food for the consciousness.
What you feed your mind matters, a lot.
When the sense doors are open to violent agitation, the mind gets bruised.
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The goal is to replace your doctor.
You have to look at the bigger picture - how this all comes together and what companies like Google are building.
This study was run through the Google Health app - you know, Fitbit.
You have the fully integrated, AI focused app. A wearable with endless new metrics being added. Full medical records integration, too - and a "navigator" that interpets your lab reports...
And now with all this data, do your diagnostics with an AI - you know, to just kind of help the doctor out... That's all.
But...
Google is running another study asking about your plan for care, symptoms, and gathering the data your doctor said to train accordingly. Wait, they want to confirm what the doctor said the symptoms meant?
If you can't see that we are headed towards replacing your doctor - then that's on you guys.
You have to look at the bigger picture - how this all comes together and what companies like Google are building.
This study was run through the Google Health app - you know, Fitbit.
You have the fully integrated, AI focused app. A wearable with endless new metrics being added. Full medical records integration, too - and a "navigator" that interpets your lab reports...
And now with all this data, do your diagnostics with an AI - you know, to just kind of help the doctor out... That's all.
But...
Google is running another study asking about your plan for care, symptoms, and gathering the data your doctor said to train accordingly. Wait, they want to confirm what the doctor said the symptoms meant?
If you can't see that we are headed towards replacing your doctor - then that's on you guys.
Our clinical trial of AMIE, a patient-facing AI system, was just published in The Lancet.
I want to explain what *I* think this study ACTUALLY means.
It's about a fundamental question: how do we know that clinical AI works?
🧵⬇️
x.com/Google/status/…
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I miss driving myself around with lots of buttons.
Feels good to be in a real Ford truck, burning gas.
In fact, looking forward to hitting up the gas station again soon. Wonderful place to visit.
I think it's time to admit Tesla got it all wrong.
Feels good to be in a real Ford truck, burning gas.
In fact, looking forward to hitting up the gas station again soon. Wonderful place to visit.
I think it's time to admit Tesla got it all wrong.
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@mikeoniron The koala made me think about how surprisingly soft the kangaroo was.
Super chill but not a wild one!
Super chill but not a wild one!
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@morganlinton @LibertyBella Another example. Muse has the "Ideas" button. And it comes up with lots of proactive ideas every day.
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Also this just came in. Muse does housekeeping and proactive work from my email every day. I didn't prompt for any of this.
When it booked my employees hotel, on its own it flagged that the employee will have to use his card at checkin and that we should let him know we'll reimburse. And hey, today itinder now that his trip ends tomorrow...
All proactive.
When it booked my employees hotel, on its own it flagged that the employee will have to use his card at checkin and that we should let him know we'll reimburse. And hey, today itinder now that his trip ends tomorrow...
All proactive.
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