Babak Javid retweeted
Innate immune memory in mucosa: where is it encoded? dlvr.it/TWBjJT #immunology
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It's not just species of the gut microbiome, or their metabolites, but also genomic variants in the bacteria, that relate to diseases and health
nature.com/articles/s4158…
nature.com/articles/s4158…
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Babak Javid retweeted
By studying sea slugs in the lab, researchers have determined how structural changes in molecules called transfer RNAs accompany behavioral habituation, an elemental form of learning. @scisignal scim.ag/3UiULAO
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Babak Javid retweeted
Turning a Staphylococcus aureus virulence factor into an antibacterial therapy dlvr.it/TW6nd9 #MicroSky
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Babak Javid retweeted
Now online! Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages dlvr.it/TW3Xtk
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Babak Javid retweeted
Online Now: Small genomes, big lessons: What viruses teach us about structure-based riboregulation dlvr.it/TW3zZ9
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Babak Javid retweeted
One of the coolest use of RAPPL by John McCutcheon and @IsraelF96135088 . They RAPPL isolated ribosomes of bacterial endosymbiont from 2 cicadas and solve structures of funky (mosaic) ribosomes.
Great work here and very happy that our method help them solve this long awaited structure.
Great work here and very happy that our method help them solve this long awaited structure.
Today is an emotional day for me. Together with Prof. John McCutcheon lab @ASU we have visualized by cryoEM what looks like a very funky ribosome from an insect endosymbiont.
We believe there are important evolutionary implications.
Here the pre-print:
biorxiv.org/content/10.648…
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Babak Javid retweeted
A marvelous profile of the incomparable Ralph Isberg, my scientific grandfather and one whose training record and discoveries influence so much in the field today. A must read for anyone interested in how to do this job right--focus on the people.
now.tufts.edu/2026/10/13/lab…
now.tufts.edu/2026/10/13/lab…
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This is a legitimately amazing paper. TL;DR: They made a microfluidic chip that can trap a million individual cells, hooked it up to a microscope, and used it to connect genetic circuits --> single-cell behaviors.
Say you want to build a complicated gene circuit, like an oscf six hours. Normally, you’d make a design, put it into cells, watch it fail, redesign it, and try again.
With this system, you can instead make a million variants in a single tube, introduce them into cells, and trap those cells in the chip to see which designs work. You can then pull out a “winning” cell using optical tweezers, or identify which gene circuit it received via in situ sequencing.
(Each circuit carries a short genetic barcode. You sequence the gene circuit variants beforehand to link each barcode to a design. Then, reading those barcodes inside the chip, using in situ sequencing, tells you which circuit each cell received.)
This is a much more scalable way to test and optimize complex ideas in synthetic biology; not only gene circuits, but perhaps also metabolic pathways. I suspect it’ll be super useful for collecting data for predictive AI models, too. Congrats @NoahOlsman!
Say you want to build a complicated gene circuit, like an oscf six hours. Normally, you’d make a design, put it into cells, watch it fail, redesign it, and try again.
With this system, you can instead make a million variants in a single tube, introduce them into cells, and trap those cells in the chip to see which designs work. You can then pull out a “winning” cell using optical tweezers, or identify which gene circuit it received via in situ sequencing.
(Each circuit carries a short genetic barcode. You sequence the gene circuit variants beforehand to link each barcode to a design. Then, reading those barcodes inside the chip, using in situ sequencing, tells you which circuit each cell received.)
This is a much more scalable way to test and optimize complex ideas in synthetic biology; not only gene circuits, but perhaps also metabolic pathways. I suspect it’ll be super useful for collecting data for predictive AI models, too. Congrats @NoahOlsman!
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Babak Javid retweeted
I could not be more delighted to see the appointment of Menna Clatworthy as Regius Professor of Medicine at @UniofOxford .
A talented scientist, a fabulous human & an outstanding clinician. Oxford have chosen well.👏👏👏
gov.uk/government/new…
A talented scientist, a fabulous human & an outstanding clinician. Oxford have chosen well.👏👏👏
gov.uk/government/new…
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Babak Javid retweeted
Postdoc opening: My lab at NYU Langone Health is looking for a new postdoctoral fellow with wet-lab experience for an exciting project.
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Babak Javid retweeted
1. CRISPR came from basic research on bacteria.
2. Optogenetics started with a discovery in algae.
3. The GFP protein comes from jellyfish.
The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
2. Optogenetics started with a discovery in algae.
3. The GFP protein comes from jellyfish.
The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
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Babak Javid retweeted
The genetic code is fixed, but the machinery reading it isn’t. Hundreds of tRNA genes, multiple tRNAs per amino acid, multiple versions of the same anticodon. The usual story is that it’s all redundancy for robustness. We wanted to know if that’s really it. We have previously shown in several instances that tRNAs act as regulators of translation and oncogenesis. This time we set out to do it systematically, and more importantly, in vivo.
biorxiv.org/content/10.648…
biorxiv.org/content/10.648…
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Babak Javid retweeted
Hundreds of human tRNA genes form a redundant repertoire for decoding the genetic code. But does redundancy imply functional equivalence?
A pan-cancer in vivo CRISPRi atlas from @genophoria and Vijay Ramani at @GladstoneInst reveals a structured landscape of tRNA dependencies.
A pan-cancer in vivo CRISPRi atlas from @genophoria and Vijay Ramani at @GladstoneInst reveals a structured landscape of tRNA dependencies.
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Amazing result. @Kalshi did not predict any of the winners of the science @NobelPrize . By that I mean not a single candidate was in top 5 closing odds.
Prediction markets may be able to predict Maduro raids, but not this. I guess it's mostly insider trading?
Prediction markets may be able to predict Maduro raids, but not this. I guess it's mostly insider trading?
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Babak Javid retweeted
l-Arginine inhibits NLRP3 inflammasome activation dlvr.it/TVnyVT
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Babak Javid retweeted
Postdoctoral position available in my lab, co-supervised by Chris Stefan. crick.ac.uk/careers-study/…
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Amazing advance and constant debate as to who was left out.
Even aside from that, in the 1980s, Foster described "algal eyes" and that it was a rhodopsin.
It's not obvious that study of "algal eyes" would eventually shed light on brain function.
*Basic science* is vital.
Even aside from that, in the 1980s, Foster described "algal eyes" and that it was a rhodopsin.
It's not obvious that study of "algal eyes" would eventually shed light on brain function.
*Basic science* is vital.
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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