A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-release…

Tomorrow at 11:30 AM PT join @VadimGladyshev @gladyshev_lab, a leader in the science of aging, and me, for a conversation on biomarkers, clocks, rejuvenation, AI, and where the field is headed
open.substack.com/live-stream/42…

Interesting new @Waymo ad for superhuman driving safety

What is "medical superintelligence" and why are we so far away from the concept?
open-access
bmjdigitalhealth.bmj.com/content/2/1/e0…

We didn't know about the role of alternative RNA splicing for response to cancer immunotherapy. Discovery of STAT2 introns that influence non-small cell lung cancer response and survival (PSI=percent spliced in) @ScienceMagazine
science.org/doi/10.1126/sc…

Bone as a modulator of aging.
Dynamic force on the tibia is sensed and extends healthspan and lifespan, with reduced inflammation, and bone marrow immunosenescence in the experimental model. When Piezo1 (pressure sensor) receptor was deleted, resulting in lack of sensing, the l_Metabolism
sciencedirect.com/science/articl…

"The longevity industry is a goldrush without gold."
and other strong words about 2 delusions @TheLancet
thelancet.com/journals/lance…

Just published @ScienceMagazine
Higher medical accuracy at lower cost
A 3-agent AI for sequential diagnosis nearly doubled accuracy compared with physicians for >300 @NEJM CPC cases and >300 ER cases AND substantially lowered cost, also exceeded performance of many AI models, physici
@erichorvitz @Dominic1King @mustafasuleyman

Imagine a system for people with diabetes that could continuously monitor glucose and keep its level steady and under control without drugs.
Oh, here it is, at least one that works well in mice
@ScienceMagazine science.org/doi/10.1126/sc…

Just published @ScienceMagazine
Higher medical accuracy at lower cost
A 3-agent AI for sequential diagnosis nearly doubled accuracy compared with physicians for >300 @NEJM CPC cases and >300 ER cases AND substantially lowered cost, also exceeded performance of many AI models, physici
@erichorvitz @Dominic1King @mustafasuleyman

It's the cover
here's the link science.org/doi/10.1126/sc…

As far as I know, this is the 1st demonstration for AI's capability for reducing diagnostic testing, lowering costs, while markedly improving accuracy.

Just in time for the World Series, the "robot-ump"
science.org/content/articl… by @sciencecohen @ScienceMagazine

How to improve outcomes in patients with metastatic melanoma post-surgical resection, and specifically, vs controls:
—Reduce 2-year mortality from 82 to 70%
—Reduce recurrence by 42%
Treat with a personalized mRNA neoantigen vaccine
@statnews @adamfeuerstein
statnews.com/2026/10/22/esm…

Targeting neoantigens, the proteins or peptides on the surface of cancer cells, is the basis for personalized cancer vaccines. What is the ideal neoantigen? @Cancer_Cell sciencedirect.com/science/articl…

How a poor diet affects adverse effects to cancer immunotherapy via T reg cell fragility and promoting inflammation
Deconvoluting what can be fatal reactions to ICI via the experimental model
@CellCellPress
cell.com/cell/fulltext/…

This is a remarkable story @RadicalNumerics and a real use case of how AI can be used for new treatments.

It's great to see tech leaders investing, philanthropically supporting biomedical science. Editorial and Feature @Nature re: upside and some concerns
nature.com/articles/d4158…
nature.com/articles/d4158…

Just published @Nature
A 3-agent AI personal health agent exceeded performance of a large language model/chatbot and serves as a foundation to build on for integrating sensor data, medical knowledge and coaching
nature.com/articles/s4158…

Accompanying @NatureNV pointing out the next big step would be to do a RCT for health outcomes nature.com/articles/d4158… by @2plus2make5

Quite a lede
"For the first time, scientists say they have used viruses designed by AI to treat a human patient."
Front page @nytimes
gift link nytimes.com/2026/10/20/sci…

Details of the phage therapy for antimicrobial resistance
@RadicalNumerics (from their website)
radicalnumerics.ai/blog/omnii-pha…