Our appreciation in Diabetologia of Steve Ashcroft who sadly passed away in November. Steve made fundamental contributions to our understanding of beta cell glucose sensing including the substrate site hypothesis and the role of KATP channels.
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📢
#CIHR, #NSERC and #SSHRC are proud to launch the new Canada Impact+ Research Training Awards to support the recruitment of international doctoral students and postdoctoral researchers to Canada.
Learn more about this new initiative:
▶️ tinyurl.com/yc54p4da
#CIHR, #NSERC and #SSHRC are proud to launch the new Canada Impact+ Research Training Awards to support the recruitment of international doctoral students and postdoctoral researchers to Canada.
Learn more about this new initiative:
▶️ tinyurl.com/yc54p4da
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Guy Rutter1 retweeted
📢Today, the #GC launched new programs to attract international researchers to Canada.
✅ Canada Impact+ Research Chairs
✅ Canada Impact+ Emerging Leaders
Get all the details here: canada.ca/en/impact-plus…
@SSHRC_CRSH @NSERC_CRSNG
@CIHR_IRSC @InnovationCA @ISED_CA
✅ Canada Impact+ Research Chairs
✅ Canada Impact+ Emerging Leaders
Get all the details here: canada.ca/en/impact-plus…
@SSHRC_CRSH @NSERC_CRSNG
@CIHR_IRSC @InnovationCA @ISED_CA
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Leveraging the inhibition of disallowed beta cell genes as a therapeutic strategy!
LDHA inhibition could be a novel therapeutic strategy for #diabetes treatment link.springer.com/article/10.100… @DiabetologiaJnl
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Canada’s new government is investing big to attract world-class talent in science and technology — and become an innovation powerhouse.
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Guy Rutter1 retweeted
29%—That's a lot of weight loss, folks
Triple GLP-1 drug receptor retatrutide
Compares with avg weight loss with Zepbound 21%, Wegovy (Ozempic) 15%
nytimes.com/2025/12/11/hea…
Triple GLP-1 drug receptor retatrutide
Compares with avg weight loss with Zepbound 21%, Wegovy (Ozempic) 15%
nytimes.com/2025/12/11/hea…
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ER calcium stores contribute to glucose-induced Ca2 waves and interce... sciencedirect.com/science/articl… Revisiting an old question with new tools! @L_F_D_S #BillLouch @CRCHUM @CRCHUM_CELLS @wellcometrust @CIHR_IRSC @BT1D_CA
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Guy Rutter1 retweeted
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia | Nature Metabolism nature.com/articles/s4225…
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Out today in Diabetes! Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice | Diabetes | American Diabetes Association @CRCHUM @ImperialMDR diabetesjournals.org/diabetes/artic…
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#Throwback
REVIEW | @guy_rutter , @BennyScience et al
Exploring pancreatic beta-cell subgroups and their connectivity
nature.com/articles/s4225…
REVIEW | @guy_rutter , @BennyScience et al
Exploring pancreatic beta-cell subgroups and their connectivity
nature.com/articles/s4225…
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Relaunching our @CRCHUM Cardiometabolic Axis data sessions data sessions today with amazing talks from #mathiasguayasamin and #luisdelgadillosilva. #ciaranmurphyroyal @CRCHUM_CELLS
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Not one, but TWO endocrinologists to join the Canadian Medical Hall of Fame in 2026. Both Drs Hegele and Zinman have changed the way we treat metabolic disorders forever. In addition though … they are just kind humans. Congratulations!!🎉🎊🎈
Join us in congratulating the #2026CMHFInductees!cdnmedhall.ca/induction
PAVEL HAMET, MD PhD
ROBERT ALEXANDER HEGELE, MD
MICHAEL D. HILL, MD
MARY R. L'ABBÉ, PhD
MORAG PARK, PhD
BERNARD ZINMAN, MDCM
@kellygrant1 @Megan_Ogilvie @LaurenPelley @DubinskiKa4985 @JenLeeCBC @Avis_Favaro
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Important new review from my @CRCHUM colleague #MarcDonath
Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field sciencedirect.com/science/articl…
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I‑BET151 modulates glucokinase gene expression and beta cellfunction in part through changes in FOXO1 expression rdcu.be/eIBCo
Assoc. Prof Yusuf Ali's team @NTU_LKCMedicine in collaboration with @guy_rutter and @astar_research discovered that BET protein inhibition reatic β-cell function.
🔹 ↑ Glucose excursions
🔹 ↓ Insulin response
🔹 Downregulation of MODY genes (Hnf4α, Gck, Hnf1α, Glut2) & PI3K–Akt pathway
⚠️ BET therapies may impair β-cell health — caution warranted.
#Diabetes #Epigenetics #BETinhibition
Assoc. Prof Yusuf Ali's team @NTU_LKCMedicine in collaboration with @guy_rutter and @astar_research discovered that BET protein inhibition reatic β-cell function.
🔹 ↑ Glucose excursions
🔹 ↓ Insulin response
🔹 Downregulation of MODY genes (Hnf4α, Gck, Hnf1α, Glut2) & PI3K–Akt pathway
⚠️ BET therapies may impair β-cell health — caution warranted.
#Diabetes #Epigenetics #BETinhibition
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All true.
But the same rigour should be applied to ALL the antibodies we use. Those against glucokinase are a case in point.
But the same rigour should be applied to ALL the antibodies we use. Those against glucokinase are a case in point.
In some of these papers, glp1r detection is a small element. In others it's a large element. Don't trust antibody vendors, and do the legwork. As a field we are always happy to provide reagents/models to help with validation.
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Our new report with #YaChiHuang #MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv biorxiv.org/content/10.110…
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#Throwback
REVIEW | @guy_rutter , @BennyScience et al
Exploring #pancreatic #BetaCell subgroups and their connectivity
nature.com/articles/s4225…
REVIEW | @guy_rutter , @BennyScience et al
Exploring #pancreatic #BetaCell subgroups and their connectivity
nature.com/articles/s4225…
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Our new kid on the block to rival or beat existing dual agonists? Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001 - PubMed. pubmed.ncbi.nlm.nih.gov/40831316/
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The influence of metformin treatment on the circulating proteome - PubMed. Important new study led by @LeentHart and the EU-funded IMI -Rhapsody and IMI-DIRECT consortia pubmed.ncbi.nlm.nih.gov/40684475/
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Thanks again @SoleimanpourLab for the opportunity to be involved and to #MarieGasser for her vital input! Also grateful to the ever-resourceful @carapetop for her help!
@nesvilab @epgnomike @guy_rutter @NIDDKgov @ADA_DiabetesPro @BreakthroughT1D @DeptVetAffairs P.S. we would be remiss if we did not also thank the amazing reviewers and editor who made our work better and more complete. As well as @cevansmo for the lovely commentary on our work! nature.com/articles/s4225…
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