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1/ 🧵Thrilled to share that our new paper was just published at @ScienceTM @aaas ! 🎉
We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫
science.org/doi/10.1126/sc…
A thread ⬇️
We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫
science.org/doi/10.1126/sc…
A thread ⬇️
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Timothée Bruel retweeted
Cross-reactive antibody and functional T-cell responses to Bundibugyo virus induced by Zaire ebolavirus vaccination and infection
medrxiv.org/content/10.648… #Ebola #vaccine #outbreak
medrxiv.org/content/10.648… #Ebola #vaccine #outbreak
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Timothée Bruel retweeted
Type I IFN autoantibodies in three of seven Europeans with life-threatening Usutu virus infection rupress.org/jhi/article/3/…
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Timothée Bruel retweeted
Less than two weeks left to apply for a PhD in the lab!
Details and application 👇 👇 👇
Details and application 👇 👇 👇
🧑🔬PhD Opportunity!
Together with @Mahan_Ghafari (Oxford uni) we're advertising an exciting project on exploring the deep evolutionary and structural conservation of viral antigen proteins, through Pasteur's prestigious PPU program!
Apply here: ppu.pasteur.fr
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Timothée Bruel retweeted
Introducing Sentira Single Cell, a new agentic analysis platform. Explore Chromium data with natural language, refine analyses in editable, reproducible notebooks and stay in control from scientific questions to experimental conclusions: bit.ly/47PCu18
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Timothée Bruel retweeted
I’m recruiting a Postdoctoral Fellow to join my lab at the Harvard T.H. Chan School of Public Health, working on innate immunity to RNA viruses.
To apply, please email a CV and a letter of interest to jlpinfo@hsphsun3.harvard.edu. Details: academicpositions.harvard.edu/postings/16952
To apply, please email a CV and a letter of interest to jlpinfo@hsphsun3.harvard.edu. Details: academicpositions.harvard.edu/postings/16952
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Timothée Bruel retweeted
🚀 Excited to share BindClaw! 🦀
Starting from a prompt or research paper, BindClaw connects biological mechanisms to protein design: identify targets and binding sites → build mechanism-specific computational assays → generate and assess binders → refine designs using the to evaluate whether designs fit the intended biological objective, including competition with a native partner and preference for a particular molecular state. 🧬
In a human-guided calmodulin campaign, 15 of 18 designs showed binding to calcium-loaded CaM, including subnanomolar binders supported by both BLI and SPR.
This work is an incredible team effort together with @DidiKieran , @saint__ai, @ Kyle Gion and @sacdallago and many others!
📄paper/project: research.nvidia.com/labs/dbr/asset…
💻code: will be released in a few weeks!
Starting from a prompt or research paper, BindClaw connects biological mechanisms to protein design: identify targets and binding sites → build mechanism-specific computational assays → generate and assess binders → refine designs using the to evaluate whether designs fit the intended biological objective, including competition with a native partner and preference for a particular molecular state. 🧬
In a human-guided calmodulin campaign, 15 of 18 designs showed binding to calcium-loaded CaM, including subnanomolar binders supported by both BLI and SPR.
This work is an incredible team effort together with @DidiKieran , @saint__ai, @ Kyle Gion and @sacdallago and many others!
📄paper/project: research.nvidia.com/labs/dbr/asset…
💻code: will be released in a few weeks!
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Timothée Bruel retweeted
🎃 All treats, no tricks.
Run RFD4-Proteina on RTX PRO 6000 GPUs on @huggingface, free until Nov 4. You can design proteins in your browser without installing anything. huggingface.co/spaces/nvidia/…
Run RFD4-Proteina on RTX PRO 6000 GPUs on @huggingface, free until Nov 4. You can design proteins in your browser without installing anything. huggingface.co/spaces/nvidia/…
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Timothée Bruel retweeted
Paper alert from our lab in collaboration with Nadine Laguette and Dorothée MISSÉ’s labs. Have you ever heard if Tonate virus? :)
The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus infection journals.plos.org/plosntds/artic…
The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus infection journals.plos.org/plosntds/artic…
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« For clinical trials, I'd even call human-only review dangerous »
I felt like that AI reviews are reliable and objective as compared to human ones.
Amazing to seer this quantified.
Given the burden of reviewing it raises many interesting question…
I felt like that AI reviews are reliable and objective as compared to human ones.
Amazing to seer this quantified.
Given the burden of reviewing it raises many interesting question…
Lots of debate this week on whether journals should ban AI in peer review.
We actually tested this in our new preprint, and the results were pretty clear to me.
For context, I've reviewed for most of the big journals and evaluated 1,000 human reviews as an editor. I love to ce.
TLDR: From now on I won't do any peer review without AI. For clinical trials, I'd even call human-only review dangerous 🧵
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Timothée Bruel retweeted
Our BA.3.2.2 study is now published in Nature Microbiology!
Counterintuitively, we found that ancestral-strain immune imprinting protects against BA.3.2.2 through IGHV3-53/66 Class 1 antibodies, helping explain why BA.3.2.2 selectively infects children.
doi.org/10.1038/s41564…
Counterintuitively, we found that ancestral-strain immune imprinting protects against BA.3.2.2 through IGHV3-53/66 Class 1 antibodies, helping explain why BA.3.2.2 selectively infects children.
doi.org/10.1038/s41564…
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Timothée Bruel retweeted
Nature research paper: Structural basis for protocadherin-1 recognition by New World hantaviruses
go.nature.com/4ieepFS
go.nature.com/4ieepFS
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What an amazing opportunity !
Today, we’re announcing an open call for guest investigators in life sciences. Over 8–12 weeks, guest investigators will work directly with my team and other Anthropic researchers to produce analyses and tools for their work. We’ll run our models and harnesses, at no cost to them. We’ll work together to open-source the resulting data, artifacts, and code, and write preprints about what we find.
We want humans to remain at the center of scientific discovery, deciding what questions to pursue, and how to pursue them. Those decisions are not ours to make alone. This open call is part of our ongoing efforts at Anthropic to support researchers and accelerate scientific discovery.
I’m looking for principal investigators and their research groups at academic institutions, nonprofits, or government labs, working in causal human biology, structural and computational molecular biology, medicinal chemistry, drug discovery, and clinical science.
Applications are open for about 14 days: anthropic.com/news/open-call…
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Timothée Bruel retweeted
Need compute to compete in protein design competitions like this one?
proteinbase.com/competitions/a…
RFD4-Proteina is now on Hugging Face with two weeks of NVIDIA-sponsored access. 🧵👇
proteinbase.com/competitions/a…
RFD4-Proteina is now on Hugging Face with two weeks of NVIDIA-sponsored access. 🧵👇
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Timothée Bruel retweeted
China has selected its first group of young researchers to receive funding for up to 15 years, in one of the longest research grants on offer to scientists globally
go.nature.com/4z4Q3pw
go.nature.com/4z4Q3pw
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Timothée Bruel retweeted
Here's the link: arxiv.org/pdf/2601.23265…
If you want more practical ai gems and a list of full free ai resources, go here: simplifyingai.co/subscribe
If you want more practical ai gems and a list of full free ai resources, go here: simplifyingai.co/subscribe
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Timothée Bruel retweeted
We are offering 10,000 scientists the highest usage tier in Google Antigravity free of charge for 6 months. Please apply! forms.gle/WvmBbPvRbpKG1B…
Gemini 4 Argon is now globally available.
Built to solve your hardest problems from start to finish, the model brings frontier capabilities across coding, enterprise workflows, and cyber defense.
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Timothée Bruel retweeted
Antiviral immunity via telomerase-like reverse transcription in bacteria nature.com/articles/s4158…
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Timothée Bruel retweeted
Looks like an early flu season in the US.
Flu season is here and we're currently seeing a rise in flu emergency department visits, earlier than in previous seasons. Now is the time to get your flu shot! All New Yorkers 6 months and older should get an annual flu vaccine.
Learn more: nyc.gov/flu
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Timothée Bruel retweeted
Large upload from Ontario yesterday, providing striking revelations about the evolution of PJ.2.1.
First, there is yet another hugely divergent branch of PJ.2.
This isn't one variant: it's four.
More & more, this resembles the emergence of BA.1/2/3. What is happening? 1/11
First, there is yet another hugely divergent branch of PJ.2.
This isn't one variant: it's four.
More & more, this resembles the emergence of BA.1/2/3. What is happening? 1/11
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Timothée Bruel retweeted
L'épidémie de #grippe débute particulièrement tôt aux Etats-Unis (mais aussi au Royaume-Uni notamment) : ce pourrait être "une saison incroyablement précoce" et "il se trame quelque chose".
Le virus H1N1 est largement majoritaire, mais avec une nouvelle mutation, la G155E, qui .
En effet, "certaines souches porteuses de cette mutation sont, dans certains cas, moins bien reconnues par les anticorps humains préexistants", d'après un preprint.
A suivre !
nature.com/articles/d4158…
Le virus H1N1 est largement majoritaire, mais avec une nouvelle mutation, la G155E, qui .
En effet, "certaines souches porteuses de cette mutation sont, dans certains cas, moins bien reconnues par les anticorps humains préexistants", d'après un preprint.
A suivre !
nature.com/articles/d4158…
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