Pinned Tweet
Welcome to the Margulies Lab twitter! We’re excited to be here and share all things heart related 🫀
2
5
50
Margulies Lab retweeted
Grateful to have worked with such a dedicated team in the @AranyLab and @MarguliesLab to bring this discovery to fruition. And thanks @SarnoffCardio for all your support!
We've not understood why SGLT2 drugs (like empagliflozin, Jardiance) have marked protective heart benefit.
Today @ScienceMagazine a mechanism unraveled for improving cardiac metabolism and fuel efficiency
science.org/doi/10.1126/sc…
2
3
28
3,323
Margulies Lab retweeted
#MechanicalStress to #MetabolicDysfunction & #Contractile impairment with #Cytoskeletal #Remodeling & #AMPK #Signaling as potential #TherapeuticTargets in #HeartFailure doi.org/10.1016/j.celr… @MarguliesLab #TranslationalScience
0
1
0
50
Margulies Lab retweeted
In KETO-HFpEF, we integrated CPET, echo, lung US, tonometry, metabolites, isotope tracer, & leg MRI. Ketone ester didn't ⬆️ exercise, despite ⬇️filling pressure & glucose use at rest/exercise
Simpub #ACC25 #JACCHF
🙏 #PZamani @MarguliesLab &team
@PennCardiology @DukeHeartCenter
Simpub #ACC25 #JACCHF
🙏 #PZamani @MarguliesLab &team
@PennCardiology @DukeHeartCenter
1
11
33
2,655
Margulies Lab retweeted
From monocytes pulling matrix by @KoladeAdebowal1 to cardiac in vitro models by Benjamin Lee from @MarguliesLab we continue the mechanobiofun at #cmbes2025 @ucsdbe @PennMedicine @PennCVI @UCSDJacobs
1
7
34
1,742
Margulies Lab retweeted
Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i
Simpub #AHA24 & @JACCJournals #JACCBTS
jacc.org/doi/10.1016/j.…
🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team
@DukeHeartCenter @DukeMPI
Simpub #AHA24 & @JACCJournals #JACCBTS
jacc.org/doi/10.1016/j.…
🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team
@DukeHeartCenter @DukeMPI
0
12
42
6,303
Congratulations @mikeibrahimmd !!
The @STS_CTsurgery has awarded @mikeibrahimmd 🩺 funding to research t-tubule remodeling in the cardiac muscle cells of people w/ #heartfailure.
This is the 1st time the award 🏆 has been granted to a cardiothoracic surgeon.
Learn more ⬇️ spr.ly/6010Wuwe2
0
0
2
189
Congratulations to @AlexiaVite93 on placing in the Lightening Talk competition at @ISHR_NAS meeting in Long Beach, CA
0
1
6
194
Margulies Lab retweeted
CVI's Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/39018366/
1
5
20
927
Margulies Lab retweeted
We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…
3
33
137
20,573
Margulies Lab retweeted
Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser scim.ag/7Nf
0
6
11
1,555
Margulies Lab retweeted
Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab
1/5
tinyurl.com/ynn6r2mz
1/5
tinyurl.com/ynn6r2mz
2
18
68
6,658
Margulies Lab retweeted
A new study by @Prosser_Lab and @MarguliesLab found that inhibiting vasohibin reduced heart muscle stiffness. This could lead to new treatments for heart failure with preserved ejection fraction (HFpEF) spr.ly/6013i9WMc
1
3
14
1,402
Margulies Lab retweeted
Congratulations Alexia Vite! Awarded the American Heart Association’s Career Development Award and the Second Century Early Faculty Independence Award
0
4
17
696
Margulies Lab retweeted
CVI’s Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/38349539/
0
3
11
479
Congratulations to lab member/Research Assistant Professor @AlexiaVite93 on being awarded both (!!) the AHA CDA and Second Century Early Faculty Independence Award!
1
2
9
820
Margulies Lab retweeted
Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible!
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
4
7
41
3,608
Margulies Lab retweeted
New research examines the functional impact of alternative metabolic substrates in failing human cardiomyocytes ft. @AlexiaVite93, Timothy Matsuura, @kbedi88, Emily Flam, @AranyLab, @DanKellyPennCVI & @MarguliesLab (@PennCVI/ @PennCardiology) tinyurl.com/msp5hsma
0
5
11
1,236
Margulies Lab retweeted
Mechanical memory of human iPS-derived fibroblasts and cardiomyocytes.
link.springer.com/article/10.100…
link.springer.com/article/10.100…
0
4
2
415
In our new study led by @NesrineBouhrira , we explore how rapid induction of stiffness-induced mechanical memory in cardiomyocytes suggests potential interventions for maladaptive myocardial stiffening @BasicResCardiol @AlexiaVite93 link.springer.com/article/10.100…
0
3
10
543