We're excited to introduce the GPCR Evolution Database - an open-access resource for evolutionary analysis of GPCRs 🎉

👉 gpcrevolution.org
📄 doi.org/10.64898/2026.…

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NIH grant training video: “The review process can be discussed with no one. This includes your lab members, colleagues…”Me trying to figure out if everyone else is fair game since they just defined "no one" as a specific list: 👁️👄👁️

New paper!

How do hundreds of GPCRs maintain the same activation mechanism while evolving to recognize completely different signaling partners?

We developed an evolutionary framework that separates residues responsible for shared GPCR functions from those driving specialization

A ligand-binding sensor domain got a tiny insertion from cytochrome c, which contained a heme-binding motif, and now it is a nitric oxide sensor. As simple as that: biorxiv.org/content/10.648…

A really cool platform for annotating new bacterial genomes and metagenomes. Intuitive, biologist-friendly interface and a powerful gene neighborhood tool. So, if you have a new (meta)genome - don't go anywhere else. It's free (I don't know why -)) - seqhub.org

What are the odds? Two PNAS acceptances, 28 minutes apart. Maybe I should start buying lottery tickets?

We keep learning new things about bacterial flagella:
biorxiv.org/content/10.110…

ChatGPT says:
The two spellings Zhulin and Jouline are both transliterations of the same original Russian surname Жулин — but they follow different conventions: Zhulin - Anglo-style transliteration, JoulineFrench-style transliteration. Are we clear now :-)?

Our last review now out in Trends In Microbiology: Structural and functional diversity of sensor domains in bacterial transmembrane receptors @BlastMeetings @SEMicrobiologia @miguel_matilla @Gavirius @Eli_Monteagudo @zhulinlab
sciencedirect.com/science/articl…

Cache-containing chemoreceptors by AlphaFold. One is sober, another is drunk as a skunk. Managed to cross the membrane twice. "How many ligands did you have, Dude?"

Our heartfelt thanks to our reviewers, authors, readers, and followers. In 2024, we achieved over 1.075 million full reads and published 227 articles. This incredible milestone wouldn’t have been possible without your continued support.

Interested in anti-bacteriophage defense systems? We have an open PhD position in cell biology of bacteria and bacteriophages: nature.com/naturecareers/…

Not only a beautiful image and a beautiful structure, but also an example of a tour de force that can be achieved when two talented assistant professors join forces!

Just appeared: How knowing physics helps to understand bacterial strategies of resource allocation. Congratulation @LisevichIra on this paper! nature.com/articles/s4146…

Phosphorylated CheV interacts with a subset of chemoreceptors biorxiv.org/content/10.110… #biorxiv_micrbio

Usually, things evolve from simple to complex, but occasionally they say "Well, wait a minute, let's go back to where we were..."
pnas.org/doi/10.1073/pn…

The Institut Pasteur is leaving X.
Due to serious issues observed since its acquisition by Elon Musk, the Institut Pasteur is suspending its activities on this platform starting today and invites its followers to join on other platforms. ➡️ linktr.ee/institutpasteur

The recent COG update paper, now with page numbers: academic.oup.com/nar/article/53…

A really cool concise review by @EmonetLab looking at bacterial chemotaxis from the physicist's point of view:
cell.com/current-biolog…

It was a delight to give a talk at this amazing amphitheater during #IUMS2024, especially after the inspiring keynote lecture by @ACasadevall1 . Thank you @IUMSmicrobio for the invitation! Glad to represent @ASMicrobiology at this global forum.