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A suite of engineered mice for interrogating psychedelic drug actions
#psychedelics
Congrats to Yi-ting, Ariel, Bill, Gavin, Dewran, Pierre and too many others to mention. A yuuge effort and we hope that folks will find these mice useful
nature.com/articles/s4159…
#psychedelics
Congrats to Yi-ting, Ariel, Bill, Gavin, Dewran, Pierre and too many others to mention. A yuuge effort and we hope that folks will find these mice useful
nature.com/articles/s4159…
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BryanRoth retweeted
Two young doctors.
Dead from Ebola within two days in eastern DRC.
Dr. Safari Samuel died Oct. 29. Dr. Marie-France Shogogo died Oct. 28.
One had graduated two years ago.
The other, three.
Dead from Ebola within two days in eastern DRC.
Dr. Safari Samuel died Oct. 29. Dr. Marie-France Shogogo died Oct. 28.
One had graduated two years ago.
The other, three.
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BryanRoth retweeted
The final test of freedom is this: Can you remain the same person in praise, in insult, in gain, and in loss?
— Seneca
— Seneca
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BryanRoth retweeted
Serotonin signaling enhances phagocytosis by brain macrophages through Htr2b and alleviates brain injury after stroke @NatureNeuro
nature.com/articles/s4159…
nature.com/articles/s4159…
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Third doctor dies of Ebola in under 72 hours at one Beni treatment centre in DRC.
Beni has had 661 cases and 443 deaths, a 67% death rate.
Beni has had 661 cases and 443 deaths, a 67% death rate.
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Want advice on your aims page? Pull the study section’s past 3 rosters and have claude read all their publications/websites and create a profile for each with special attention to standing members. Then call a group of agents that mirror each one’s perspectives. Teach them the NIH scoring rules and have them critique your page. Highlight common faults and strategize on how to please as many as possible. Wash, rinse, repeat. Then do it again on GPT.
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BryanRoth retweeted
BREAKING: Judge Reyes says she is appointing a special master to investigate whether DOJ and DOI officials repeatedly lied to her in the golf course case.
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The Temptations
"Papa Was A Rolling Stone"
Happy birthday to #OtisWilson co-founding member, second tenor-baritone singer, and sole surviving original member of the legendary Motown vocal group #TheTemptations Born on October 30th, 1941.
🎉🎉🎉🎉🎉🎉🎉🎉
"Papa Was A Rolling Stone"
Happy birthday to #OtisWilson co-founding member, second tenor-baritone singer, and sole surviving original member of the legendary Motown vocal group #TheTemptations Born on October 30th, 1941.
🎉🎉🎉🎉🎉🎉🎉🎉
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Regarded by many as one of the best written, best acted scenes in Sitcom history.
PHILIP BAKER HALL delivers an all-time performance as ‘Lt. Bookman’ —The Library Cop, a role that changed this hugely talented Actor’s life & career forever.
PHILIP BAKER HALL delivers an all-time performance as ‘Lt. Bookman’ —The Library Cop, a role that changed this hugely talented Actor’s life & career forever.
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@neerajadeshp Those who have had to restart a lab from scratch understand the loss: grants, floor plans, expensive equipment, unique biological samples, reagents, supplies, licenses; and hiring people with precious experience in executing experiments with exquisite care, troubleshooting savvy.
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mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells | PNAS pnas.org/doi/10.1073/pn…
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This does not mean they are devoid of side effects. Hppd is real as is psychosis. Both apparently relatively rare but if it happens to you or a loved one little solace.
How is it that quacks keep saying this stuff?
There's literally no toxicity from psychedelics.
They are among the safest medicines on the planet.
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BryanRoth retweeted
Very sad to hear about the passing of Boris Tabakoff. Boris had an incredible career and influence in the alcohol research field. We've had an ongoing collaboration for over a decade and I always enjoyed our discussions and was looking forward to our lunches at RSA and SFN.
You will be missed by many, rest in peace Boris.
millerfhed.com/obituaries/dr-…
You will be missed by many, rest in peace Boris.
millerfhed.com/obituaries/dr-…
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Synthetic coolants may increase the abuse liability of nicotine-containing e-cigarettes
nature.com/articles/s4138…
nature.com/articles/s4138…
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Michael Levin kills me. Because there's an interesting observation here (that maybe you can bias cortical cultures to grow in a certain direction), confounded by the lack of an effective control (checking to see if you can bias cortical cultures to grow in any other direction or if you've just made them always go left no matter what), completely muddled by some nonsense theory (something about "training cells out of disease states").
All of his papers are like this. An interesting, usually unreproducible observation; zero interest in effective controls or interrogating whether it's a robust phenomenon; a lot of handwaving on top.
All of his papers are like this. An interesting, usually unreproducible observation; zero interest in effective controls or interrogating whether it's a robust phenomenon; a lot of handwaving on top.
Ever wonder if eventually cells could be trained out of disease states? We're on the path; first steps:
New #preprint - @WesleyPClawson
"Goal directed closed-loop training of network bursts in cortical cultures produces improved performance and error correction over days"
biorxiv.org/content/10.648…
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This does not mean they are devoid of side effects. Hppd is real as is psychosis. Both apparently relatively rare but if it happens to you or a loved one little solace.
How is it that quacks keep saying this stuff?
There's literally no toxicity from psychedelics.
They are among the safest medicines on the planet.
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BryanRoth retweeted
Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation
elifesciences.org/articles/11038…
elifesciences.org/articles/11038…
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The VA has picked ten sites for the first approved psychedelic therapies.
A senior VHA adviser at Horizons: it’ll be “a challenge in the first year to treat four digits’ worth of patients.”
About 2.1 million veterans in VA care have PTSD or depression.
This week’s psychedelic policy briefing ↓
A senior VHA adviser at Horizons: it’ll be “a challenge in the first year to treat four digits’ worth of patients.”
About 2.1 million veterans in VA care have PTSD or depression.
This week’s psychedelic policy briefing ↓
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"...psychedelic-related psychosis, although rare, represents a clinically relevant phenomenon, particularly among individuals with identifiable vulnerabilities.."
journals.sagepub.com/doi/10.1177/02…
journals.sagepub.com/doi/10.1177/02…
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Neural circuitry mediating hypercapnia-induced microarousal and impaired sleep depth | Science Advances science.org/doi/10.1126/sc…
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