Phenomenal read 👏👏
How does leukaemia develop? 🩸 How long does it take? ⏳
🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟
Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
doi.org/10.1038/s41586…
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Nikhil Patkar retweeted
Althought it's a bit old now but I really liked this article. Modern LLMs, at least in the current forms we get to use, are great for pattern-matching and incremental advancements, but not for abduction. The "mirror, not mind" theory. LLMs can’t jump!
tomzahavy.com/files/llms-can…
tomzahavy.com/files/llms-can…
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LLMs are great for enhancing your scientific capabilities like being helpful for code. It is terrible at hypothesis generation. In your own field/domain it will not tell you anything new. Because it is trained on what exists. It does not have the insight or reasoning of humans.
Are we entering a new golden age of scientific discovery?
We analyze 200,000+ sessions of scientists using @claudeai across academic fields to understand what drives adoption—and how much AI could accelerate science. 🧵
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Nikhil Patkar retweeted
Animals seeing their favorite person always makes me smile 😃
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Molecular MRD Monitoring in Acute Myeloid Leukemia Draft Recommendations
@AMPath
Make your opinion heard on these proposed consensus guidelines!!
amp.org/clinical-pract…
@AMPath
Make your opinion heard on these proposed consensus guidelines!!
amp.org/clinical-pract…
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OPEN COMMENT PERIOD! Draft Recommendations: Molecular MRD Monitoring in AML (Comments due Nov. 24, 2026, at 11:59 p.m. Eastern)
Read the recommendations and submit your comments here: amp.org/clinical-pract…
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Nikhil Patkar retweeted
MEASURE, the national prospective clinical protocol to validate WGS-informed AML MRD testing, is no longer under @ASH_hematology embargo!
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Could A.I. Be Conscious? It’s Definitely Possible. nytimes.com/2026/11/01/opi…
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Nikhil Patkar retweeted
Thrilled to share JEEPERS, our new study in @naturemethods on improving #cfDNA methylation profiling by correcting jagged-end errors. Led by @RuiwrWang with @max_diehn & our @StanfordMed team. #LiquidBiopsy 1/6
nature.com/articles/s4159…
nature.com/articles/s4159…
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The Hugging face incident
Who cares.... right?
Instadocs:AI gone wild (27 min only)
You should be scared about AGI means
What is the end game for OpenAI and Anthropic and all of them
Why AI need regulatory oversight worldwide 😰
Who cares.... right?
Instadocs:AI gone wild (27 min only)
You should be scared about AGI means
What is the end game for OpenAI and Anthropic and all of them
Why AI need regulatory oversight worldwide 😰
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Nikhil Patkar retweeted
Heartiest congratulations @npaesa! A long, arduous process that you led brilliantly. A pleasure to contribute to this consensus, aligned with the vision of @GTumors, & work with all co-authors and respondents..Thnx to all members of @usioffice & @urosogo for their participation
101 experts from 25 countries | New international consensus published in Urologic Oncology.
I am pleased to share our recent publication in Urologic Oncology Seminars and Original Investigations :
“Project international Delphi consensus recommendations for perioperative lymphadenectomy in cancer patients”.
Developed within the Penile Cancer Optimization Initiative (PeCOI), @GTumors and @CAU_URO , this study addresses the prevention and management of perioperative complications following inguinal lymphadenectomy, an area where considerable variability in clinical practice remains.
Key findings:
* 101 experts from 25 countries, representing a broad international and multidisciplinary panel.
* 86 clinical statements evaluated through a two-round modified Delphi process.
* Consensus achieved on 51 statements (59.3%), covering preoperative optimization, lymphatic complications, drain management, antibiotic and thromboembolic prophylaxis, wound complications, and functional rehabilitation.
* Identification of areas of clinical uncertainty requiring further research and prospective validation.
This study provides practical, consensus-based recommendations to support the standardization of perioperative care in inguinal lymphadenectomy, particularly relevant in penile cancer, where high-quality evidence remains limited.
It has been a privilege to work alongside such an outstanding group of internationally recognized experts, @LuisMedinaMD, @drmarcostobias , @jteoh_hk , Amandeep Arora , @drgaganprakash , @DoctorSotelo , and @SpiessPhilippe , as well as all the specialists who contributed to this international consensus.
My sincere thanks to everyone involved, with special thanks to Philippe Spiess, Marcos Tobias-Machado, @ARRODRIGUEZMD , and Luis G. Medina for their support and trust throughout this project.
🙏 @dr_romero_otero @JustoQuintas @RicardoBrime @DrFelixGuerrero @DavidCarracedoC @TouijerKarim @rojo_esther @DrGhaliBelkahia Belkahia Clara Briand Barriga @José Miguel Pérez Ruiz Facundo Barrientos Moll Agustín Fraile Poblador @ROC_Urologia
Published in: Urologic Oncology: Seminars and Original Investigations, 2026.
Full article: lnkd.in/e_zvaRpQ
#UrologicOncology #PenileCancer #PeCOI #DelphiConsensus #InternationalCollaboration #ROCClinic
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Nikhil Patkar retweeted
Italian pride🇮🇹🇮🇹🇮🇹
In a trial involving adults with Ph-positive acute lymphoblastic leukemia, 24-month event-free survival was 86% with the TKI–immunotherapy combination ponatinib–blinatumomab and 67% with imatinib plus chemotherapy. Full phase 3 GIMEMA ALL2820 trial results: nej.md/4scorw0
Editorial: Chemotherapy-free Treatment of Ph-Positive ALL nej.md/3VIVUC8
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Nikhil Patkar retweeted
Right on @isliquidbiopsy 🙌🏻
Time for change….
We don’t often think about the utility of liquid biopsy (cfDNA) in myeloid malignancies but it certainly has a role, particularly for capturing the molecular heterogeneity of extramedullary disease.
Read our recent @BCD_AACR paper here for more on this topic.
aacrjournals.org/bloodcancerdis…
Time for change….
We don’t often think about the utility of liquid biopsy (cfDNA) in myeloid malignancies but it certainly has a role, particularly for capturing the molecular heterogeneity of extramedullary disease.
Read our recent @BCD_AACR paper here for more on this topic.
aacrjournals.org/bloodcancerdis…
🧬 New in Blood Cancer Discovery: multiomic profiling of myeloid sarcoma reveals distinct extramedullary clonal evolution, transcriptional adaptation, and recurrent RAS pathway activation.
Importantly, ctDNA sequencing captured the molecular composition of myeloid sarcoma, noninvasive approach to profiling extramedullary AML.
@ManelEsteller @ChristianRolfo @UmbertoMalapel1 @ElJanLe @drgandara @MJOSESERRANO19 @ChristianRolfo @RobertoBoreaMD @ErulEnes @ReduzziCarol @ddemiguelperez @PasqualePisapia @BenBleibergMD @Al3ssandroRusso @ESaldanhaMD @eleonora_nicolo @DrMirallas @LuisRaezMD @DrYukselUrun
#LiquidBiopsy #ctDNA #AML #MyeloidSarcoma #ISLB
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Nikhil Patkar retweeted
Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :)
1. Mouse lineage from E0 to E13.5
science.org/doi/10.1126/sc…
2. A fluctuation test for gastruloid heterogeneity
cell.com/cell/fulltext/…
Paper #1 covered in quoted thread. More on paper #2 here. 1/n
1. Mouse lineage from E0 to E13.5
science.org/doi/10.1126/sc…
2. A fluctuation test for gastruloid heterogeneity
cell.com/cell/fulltext/…
Paper #1 covered in quoted thread. More on paper #2 here. 1/n
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
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Nikhil Patkar retweeted
We're deepening our commitment to scientific research and technological discovery by committing $150 million to the Genesis Mission.
We'll also make Claude and our technical support available to more than 15 federal agencies.
anthropic.com/news/genesis-m…
We'll also make Claude and our technical support available to more than 15 federal agencies.
anthropic.com/news/genesis-m…
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