How does leukaemia develop? 🩸 How long does it take? ⏳

🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟

Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
doi.org/10.1038/s41586…

It would not have been possible without our fantastic collaborators at @UCL_IfWH and @innovativectu, led by @Prof_UMenon, who ran UKCTOCS, or without the UKCTOCS participants themselves, without whom this research would not have been possible.

The research was largely funded by @UKRI_News and @CR_UK, with support from @wellcometrust, @NIHRresearch, ACED and @EarlyCancerCam. UKCTOCS was funded by the MRC, @CR_UK, @DHSCgovuk and @eveappeal.

How did we come to understand cancer in the light of evolutionary theory?

Nothing makes sense if not with population genetics!

In our latest @NatureRevCancer review we unpack how population genetics theory applied to somatic cells allows us to measure and predict cancer r data.

Computational modelling in oncology has gone a long way but we need to go much further.

The frontier is combining evolutionary theory with machine learning.

Link below👇

✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: nature.com/articles/s4158…
Grateful to an incredible team and global collaborators 💚💙

Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster.

We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: biorxiv.org/cgi/content/sh… 🧵

What a remarkable essay about the poignancy and marathon of a rare, high-risk acute myeloid leukemia diagnosis in a young person (Tatiana Schlossberg). So moving. 🩸🎗️💔 @ASH_hematology @SylvesterCancer @ASCO

🧵Just out in Blood @BloodPortfolio: Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
ashpublications.org/blood/article-…

We study how resistance and durable remission emerge in IDH1-mutant AML.

If blood has clonal haematopoiesis… sperm should get clonal spermatopoiesis, right? 😉
Two great @Nature papers shed new light on how mutations drive clonal selection in sperm stem cells:
🧬 Neville et al. 👉 nature.com/articles/s4158…
👨‍👩‍👦 Seplyarskiy et al. 👉 nature.com/articles/s4158…
I had the privilege of writing the accompanying News & Views: 📝 rdcu.be/eL976 (Image © Nature)

Leukocytes are present in pretty much all our body fluids (and solids). Ever wonder whether you can detect clonal hematopoiesis in body fluids beyond blood? Short answer is yes and at a VAF surprisingly similar to blood. Cool work from the MSKCC CH clinic! jci.org/articles/view/…

🚨📢❗So proud and excited to share our latest work, "Clonal Hematopoiesis Dynamics and Evolutionary Fitness During Cancer Treatment Impact Clinical Outcomes", now available: medrxiv.org/content/10.110…🧵

Biobank scale #CHIP calls are a great first pass... but to establish the true strength of disease associations we need to use deep targeted sequencing.

Highly accurate sequencing OR high throughput? We refuse to choose.

Introducing paired plus-minus sequencing (ppmSeq), a method built to deliver both. Our latest paper with @UltimaGenomics 👀👀👀

See ⬇️ for a primer on the next frontier of genomics
biorxiv.org/content/10.110…