Microbial IAM alleviates PCOS

C. aerofaciens & metabolite indole-3-acetamide (IAM) mitigate polycystic ovary syndrome pathology via activating adipose HIF-2α-ceramide signaling. Probiotic strain producing IAM shows therapeutic efficacy in mouse PCOS model
cell.com/cell-host-micr…

Our understanding for how our brain ages and why our memory slips after age 50 have been completely revamped through 2 new landmark studies of the microglia, the brain immune cells

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance
#PeanutAllergy #GutMicrobiome #FMT share.google/uqYerBcsJ9rSRs…

New paper out! 👇

Maternal gut microbiota disruption alters postpartum maternal behavior in association with modulation of stress responses and brain tryptophan metabolism in mice sciencedirect.com/science/articl…

Universal microbiome signature for CRC

Large gut microbiome meta-analysis of colorectal cancer uncovers CRC microbiome signatures universal across ages & sequencing methods & modifiable by dietary interventions, i.e. fiber.
cell.com/cell-host-micr…

Weekend read! Microbiota extends reproductive lifespan

Germ-free female mice undergo accelerated primordial follicle loss & reduced reproductive capacity that are restored upon post-natal colonization. Microbial SCFAs & fiber mitigates ovarian dysfunction
cell.com/cell-host-micr…

#Microbiota from young mice restore the function of aged ISCs.
@GutMicrobiome #aging sciencedirect.com/science/articl…

#GutMicrobiota transfer from old mice accelerates aging in adults
sciencedirect.com/science/articl…

Excited to share a new #Commentary by Marco Ventura, a leading figure in the field of #Bifidobacterium research:
“Mapping the #genomic landscape of two key human #gutmicrobial species: Bifidobacterium infantis and Bifidobacterium longum”
Read👉oaepublish.com/articles/mrr.2…
#Microbiome

Adolescent obesity induces sex-specific alterations of action control
nature.com/articles/s4138…

We analyzed 2.6M food & beverage logs from ~20,000 people to uncover (among other insights) what’s consumed every 2 hours across a 24h day.
Some usual suspects… and a few surprises.
Take a guess—then check the list 👇
nature.com/articles/s4225…
@NatMetabolism

Not just passengers!
Perspective by Colin Hill & Co examines role of phages in fecal microbiota transplants (FMTs). Phages may actively reshape the recipient’s gut by transferring genes between microbes, potentially influencing treatment success
cell.com/cell-host-micr…

Two more days until the 2nd edition of our Swiss-wide #microbiome & health event! 🇨🇭🦠

We've got a brilliant lineup of speakers and I'm excited to once again moderate the panel discussion. Make sure to register for free at
foodhealth.ch/en/agenda

Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

@NatMetabolism @E_MSchneider @jfcryan

nature.com/articles/s4225…

Our new preprint by @peowenlu @SaefIzzy @weinerlabhms and colleagues shows that nasal anti-CD3 monoclonal antibody treatment can reduce neuroinflammation in a mouse model of Long COVID, even when administered at 4 weeks after infection 🧠
biorxiv.org/content/10.648…

New online! The microbiome regulates host metabolic health and diseases through microbial enzymes dlvr.it/TRwk2W

If people with #celiacdisease lack the microbes needed to break down certain fibers, they don't benefit from consuming them

@VerduLab, @AlbertoCaminer7 & colleagues found patients with #celiacdisease had impaired microbial fiber metabolism in the small intestine, which was assof the fiber-degrading taxa:

✅ Findings align with @DrHArmstrong research on β-fructan fibers' role in inducing inflammation if the microbes needed to ferment the fiber are not present

✅ While a high fiber intake is often recommended to newly diagnosed patients with celiac disease alongside the gluten-free diet to improve constipation, these findings suggest that it's first important to restore the gut ecosystem

✅ In mice, an inulin-supplemented diet increased small intestinal short-chain fatty acids and could be used as adjuvant therapy for the gluten-free diet to promote mucosal healing, when metabolizing taxa are present

📚 Read more: nature.com/articles/s4146…

New! Online now: The gut microbiota alleviates depression by remodeling gut-brain energy metabolism dlvr.it/TRp62v

Our new study @NatureMedicine from the Human Phenotype Project: Analyzing diet and microbiome data from 10,000+ people, we found that what you eat is strongly linked to which microbes live in your gut, down to specific foods like coffee, yogurt, and milk driving distinct e also simulate personalized dietary interventions with predicted microbiome shift effects that are associated with improvements in cardiometabolic health

Read here: nature.com/articles/s4159…

HPP: humanphenotypeproject.org/home