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MK-6240 is a PET imaging agent that can discern subtle early-stage Alzheimer's brain changes. How does it interact with Alzheimer's tau filaments at a high-resolution molecular level? 🔬⚡Read on and check out our bioRxiv article:
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Sarah H. Shahmoradian retweeted
We develop an epiblast complementation strategy that enables the generation of mice from PSCs in a single step. With further optimization, we hope to develop this approach into a broadly applicable platform for generating genetically engineered mice and potentially other species.
Epiblast complementation enables generation of live offspring from pluripotent stem cells: Cell Stem Cell cell.com/cell-stem-cell…
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Sarah H. Shahmoradian retweeted
Our multi-immersion oblique plane microscope manuscript is online now.
A light-sheet system that can be adapted to different imaging tasks, including a continuous volumetric correction for imaging in media of (theoretically) any refractive index.
nature.com/articles/s4159…
A light-sheet system that can be adapted to different imaging tasks, including a continuous volumetric correction for imaging in media of (theoretically) any refractive index.
nature.com/articles/s4159…
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Sarah H. Shahmoradian retweeted
Our first protein 🥩 design paper! 🤠
Check out Minkyu's tour de force on T-REX 🦖, an agentic protein design controller for de novo binder design!
TLDR we treat protein design as an online allocation problem over heterogeneous tools (Proteina-complexa, Boltzgen, Bindcraft, ✨ etc), use 🤖 agents to reason over what tools + settings to run, designed a granular classification system to manage the agents (e.g. Rescue🛟/Explore🔎/eXploit🚀), that is all orchestrated with a deterministic controller to efficiently brrr the GPUs. 💸
T-REX 🦖 is fully open source: github.com/ml-struct-bio/…
Preprint: biorxiv.org/content/10.648…
Please let us know if you have any feedback!
Check out Minkyu's tour de force on T-REX 🦖, an agentic protein design controller for de novo binder design!
TLDR we treat protein design as an online allocation problem over heterogeneous tools (Proteina-complexa, Boltzgen, Bindcraft, ✨ etc), use 🤖 agents to reason over what tools + settings to run, designed a granular classification system to manage the agents (e.g. Rescue🛟/Explore🔎/eXploit🚀), that is all orchestrated with a deterministic controller to efficiently brrr the GPUs. 💸
T-REX 🦖 is fully open source: github.com/ml-struct-bio/…
Preprint: biorxiv.org/content/10.648…
Please let us know if you have any feedback!
Excited to share T-REX 🦖: Target-adaptive Rescue-Explore-eXploit, an agentic campaign controller for high-throughput de novo protein binder design!
T-REX treats protein design as an online agentic allocation problem to leverage diverse tools with efficient GPU usage 🧵
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Sarah H. Shahmoradian retweeted
We proudly present our latest paper: “Ligand-induced activation of RyR1 in native membranes” RyR1 is a key protein in the excitation-contraction coupling of skeletal muscle and the largest membrane protein in humans. Paper here, thread below:
nature.com/articles/s4146…
nature.com/articles/s4146…
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Sarah H. Shahmoradian retweeted
What a fun surprise to find that our work has been featured in a @JCellBiol spotlight!! Many thanks to Carlotta Peselj and Nora Vögtle for the great write up!
Spotlight: Carlotta Peselj and Nora Vögtle discuss work by Yan et al. of the @nieminm lab (hubs.la/Q0485RBr0) that provides a quantitative framework for measuring the strength & targeting efficiency of various #mitochondria targeting presequences hubs.la/Q0485VJZ0
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Sarah H. Shahmoradian retweeted
New preprint from the lab, led by the ever-talented grad student Tessa Lochetto
@tloch_! We find that loss of Pptc7 decreases lean mass, induces skeletal muscle dysfunction, and causes metabolic derangements in adult mice: doi.org/10.64898/2026.… /1
@tloch_! We find that loss of Pptc7 decreases lean mass, induces skeletal muscle dysfunction, and causes metabolic derangements in adult mice: doi.org/10.64898/2026.… /1
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Proud to see our work featured! Grateful to my thoughtful and hardworking team, and to our wonderful collaborators who make this work possible. Stay tuned, we’re excited to share some of what we’ve been working on as preprints later this year! 🤠🔬🧠
Exploring the brain one neuron at a time, the @ShahmoraLab uses nanoscale imaging to uncover how neurodegenerative diseases like Parkinson’s and ALS begin and progress. Learn about the Shahmoradian Lab and its groundbreaking research: bit.ly/4wsg3Ju #UTSWMeetTheMinds
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Sarah H. Shahmoradian retweeted
Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae.
Beautiful work by Elena, Vasya @v_mikirtumov, Jeff & Oliver Dumke's team; take a look: nature.com/articles/s4146…
Beautiful work by Elena, Vasya @v_mikirtumov, Jeff & Oliver Dumke's team; take a look: nature.com/articles/s4146…
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Sarah H. Shahmoradian retweeted
Happy to share our new study on mitigating xenogeneic barriers to chimerism through Cas13-induced host attenuation: Developmental Cell cell.com/developmental-… Congratulations to Bingbing, Shjian, Jia and the entire team!
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Grateful for the continued support from the Parkinson’s Foundation. We have exciting synuclein data to share—stay tuned :)
Dr. Sarah Shahmoradian @ShahmoraLab received a @ParkinsonDotOrg Impact Award for research mapping how a novel PET tracer binds misfolded α-synuclein fibrils in #Parkinson’s brain tissue. Learn more: bit.ly/3XoPvt8
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Sarah H. Shahmoradian retweeted
The next discovery in treating brain diseases may come from tiny cell structures. David Sanders, Ph.D., studies biomolecular condensates and their role in Alzheimer’s/ALS—work that earned him the @NIH Director’s New Innovator Award. Explore more: bit.ly/4o8rsKe #UTSWMed
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Sarah H. Shahmoradian retweeted
@MDiamond_Lab for recruiting me to this wonderful institution; @brangwynnelab for taking a chance on a postdoc with a psychology degree; @ShahmoraLab for co-leading our remarkable group of scientists; and our amazing lab members and @NIH for believing in our high risk research!
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Sarah H. Shahmoradian retweeted
Returning to Science Twitter briefly to thank the UTSW newsroom for their kind story on my New Innovator award. Humbling experience. A few thank yous to follow, as most haven't switched to the "other" place. :)
The next discovery in treating brain diseases may come from tiny cell structures. David Sanders, Ph.D., studies biomolecular condensates and their role in Alzheimer’s/ALS—work that earned him the @NIH Director’s New Innovator Award. Explore more: bit.ly/4o8rsKe #UTSWMed
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Sarah H. Shahmoradian retweeted
A UT undergrad wrote a very interesting paper that uses neural cellular automata to solve some of the Abstraction and Reasoning Corpus (ARC) AGI benchmark problems. @TexasScience
arxiv.org/abs/2506.15746
arxiv.org/abs/2506.15746
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Sarah H. Shahmoradian retweeted
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Cryogenic electron tomography (cryoET) is a revolution already in motion!
@MishaKudryashev argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: tinyurl.com/4x4bf9ze
Let’s unpack that 👇
#CryoET #StructuralBiology
Cryogenic electron tomography (cryoET) is a revolution already in motion!
@MishaKudryashev argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: tinyurl.com/4x4bf9ze
Let’s unpack that 👇
#CryoET #StructuralBiology
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Sarah H. Shahmoradian retweeted
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena Vazquez-Sarandeses, Vasya @v_mikirtumov Jeff Noel&Oli Daumke
biorxiv.org/content/10.110…
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena Vazquez-Sarandeses, Vasya @v_mikirtumov Jeff Noel&Oli Daumke
biorxiv.org/content/10.110…
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Sarah H. Shahmoradian retweeted
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
@theliulab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️biorxiv.org/content/10.110…
@theliulab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️biorxiv.org/content/10.110…
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Sarah H. Shahmoradian retweeted
Our manuscript for remote focus stabilization for oblique plane microcopy is online:
opg.optica.org/boe/fulltext.c…
opg.optica.org/boe/fulltext.c…
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Sarah H. Shahmoradian retweeted
Last night my brilliant friend with 20 years of expertise in Neuroscience including a decade at NIDA was fired because she was recently promoted for her outstanding performance and it triggered the probation period.
This is not making NIH more efficient, this is not making us healthier, this is not punishing the people who misled the public, this is destroying America’s talent.
Her work is instrumental for testing whether new medications to fight addiction are safe and efficacious before they are tested in humans. now that research is at risk.
She was the backbone of the lab the most senior person. So much knowledge, talent, know how, wasted, so much science destroyed for the wrong reason.
Sigh…
This is not making NIH more efficient, this is not making us healthier, this is not punishing the people who misled the public, this is destroying America’s talent.
Her work is instrumental for testing whether new medications to fight addiction are safe and efficacious before they are tested in humans. now that research is at risk.
She was the backbone of the lab the most senior person. So much knowledge, talent, know how, wasted, so much science destroyed for the wrong reason.
Sigh…
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Sarah H. Shahmoradian retweeted
"Don't be afraid!"
Randy Schekman says that the most successful scientists are willing to take risks. He uses 2024 chemistry laureate David Baker as an example of how embracing risk can lead to significant rewards.
Before Baker transitioned to researching structural biology he ein transport in yeast. Prior to that, he earned a bachelor's degree in philosophy and social science, demonstrating that no career change is too drastic.
Schekman was awarded the 2013 medicine prize jointly with James Rothman and Thomas Südhof for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
Randy Schekman says that the most successful scientists are willing to take risks. He uses 2024 chemistry laureate David Baker as an example of how embracing risk can lead to significant rewards.
Before Baker transitioned to researching structural biology he ein transport in yeast. Prior to that, he earned a bachelor's degree in philosophy and social science, demonstrating that no career change is too drastic.
Schekman was awarded the 2013 medicine prize jointly with James Rothman and Thomas Südhof for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
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