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So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology sciencedirect.com/science/chapte…
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Danny Saban retweeted
Our review is out in @TrendsImmuno
“From Tissue Adaptation to Disease-Associated Eosinophil States” explores how disease reshapes eosinophil identity and function—and why looking beyond cell counts matters for therapy. authors.elsevier.com/a/1o3ht5Eb0S3Q…
“From Tissue Adaptation to Disease-Associated Eosinophil States” explores how disease reshapes eosinophil identity and function—and why looking beyond cell counts matters for therapy. authors.elsevier.com/a/1o3ht5Eb0S3Q…
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Danny Saban retweeted
🌟Could we help skin rebuild itself by reprogramming its own stem cells?🪄 Deeply grateful to @CIRMnews for believing in our vision. Excited to bring it to life with Karl Willert and our teams at @UCSDMedSchool @ucsdstemcell! today.ucsd.edu/area-story/aug…
🧙🏽♀️ Spooky season is over, but it’s a great time to celebrate the everyday magic of #science! Learn about the healing power of stem cells & the #HarryPotter-esque work of our @ShiriGurCohen & Karl Willert, who were recently awarded a $2.5M @CIRMnews grant: bit.ly/4BBWbHf.
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Danny Saban retweeted
Fascinating study by @VishwaDeepDixi1 Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages: Cell cell.com/cell/fulltext/…
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Thank you to the Donald K. Johnson Eye Institute for a wonderful visit and the honor of giving the first keynote. A great reminder of how deeply intertwined Canadian and US science are: we train each other's students, build on each other's discoveries, and are stronger together.
👏 Dr. Daniel Saban @DukeU joined us today as our first keynote speaker.
His talk explored the often overlooked role of immune cells in maintaining ocular health and resilience, highlighting how the immune system contributes to protecting the eye and responding to injury and ch #NoResearchNoCure
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Danny Saban retweeted
What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy
cell.com/immunity/abstr…
cell.com/immunity/abstr…
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Danny Saban retweeted
A few more hours to place a bid on this piece! Money does not go to me, but to the child neurology foundation @Child_Neurology . pro.gofundme.com/live/auction/t…
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Danny Saban retweeted
🪄Regeneration is a conversation between stem cells and their surroundings. 🥳I’m excited to share our new review on the expanding landscape of stem cell niches and how understanding stem cell–niche dialogue could advance tissue repair and healthy aging 💪🏽
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
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Danny Saban retweeted
This has been an exciting journey, and our paper is finally out as a preprint! Together with @chihyaochung and in collaboration with Agnel Sfeir, we developed mtDIVE to explore the functional consequences of thousands of mitochondrial DNA variants biorxiv.org/content/10.648…
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Stimulating study by Kamal Khanna’s group on trained immunity and lung macrophages!
Happy to share our new paper in @Nature “Type 2 immune history trains lung macrophages for viral disease tolerance” nature.com/articles/s4158… the work was fearlessly led by @PayalYokota Thanks to all our collaborators! @nyulangone @nyugrossman
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Danny Saban retweeted
📢 To everyone on the job market who has a vision for neuroscience applied to biomedical applications & technological innovation:
The Duke Dept. of Biomedical Engineering announces a tenure-track faculty job search in neural engineering, broadly defined!
academicjobsonline.org/ajo/jobs/32784
The Duke Dept. of Biomedical Engineering announces a tenure-track faculty job search in neural engineering, broadly defined!
academicjobsonline.org/ajo/jobs/32784
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Danny Saban retweeted
New dates, same ReThink spirit! 🏄
Join us at Weizmann, May 24–26, 2027, for 3 days of bold ideas and lively discussions shaping the future of neuroimmunology. Explore our speakers and register: conferences.weizmann.ac.il/RTN2026/ #ReThinkNeuroimmunology
Join us at Weizmann, May 24–26, 2027, for 3 days of bold ideas and lively discussions shaping the future of neuroimmunology. Explore our speakers and register: conferences.weizmann.ac.il/RTN2026/ #ReThinkNeuroimmunology
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Danny Saban retweeted
One unsolicited piece of advice for new #gradstudents. Don't settle on ALL of your #rotations before school starts. Use the first semester to explore. Talk to people! Check out labs and areas that you haven't considered! Go outside of your comfort zone! Let yourself be surprised!
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a 427-sample single-cell atlas of multiple myeloma across 341 individuals, linked to genetics and detailed clinical data. Very exciting study by @IdoAmitLab and Co !
Does scale limit what we can discover?
In our new @NatureGenet study, led by @MorZada3 & @Anna_Kurilovich, we built a 427-sample single-cell atlas of multiple myeloma across 341 individuals, linked to genetics and detailed clinical data 🧵 (1/15)
🔗 nature.com/articles/s4158…
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Danny Saban retweeted
🎉 Excited to share our new paper in Immunity!
Can a tissue remember inflammation after the inflammation itself is gone?
We find that it can—and that this memory can be stored in an unexpected place: the extracellular matrix (ECM).
🧵👇
cell.com/immunity/abstr…
Can a tissue remember inflammation after the inflammation itself is gone?
We find that it can—and that this memory can be stored in an unexpected place: the extracellular matrix (ECM).
🧵👇
cell.com/immunity/abstr…
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Danny Saban retweeted
Excited to share our new Perspective in @natBME!
What if drug development could learn continuously from the data generated along the way?
We propose a data-driven framework to turn biological and clinical data into a feedback loop for designing better immunotherapies
What if drug development could learn continuously from the data generated along the way?
We propose a data-driven framework to turn biological and clinical data into a feedback loop for designing better immunotherapies
Genomic data generation is exploding. Translation into new therapies is not.
Our new @natBME Perspective proposes data-centric feedback loops combining ML, single-cell genomics & in vivo perturbations to accelerate next-gen immunotherapy @Rotem_Shalita
nature.com/articles/s4155…
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Check out our new preprint, Beatty et al!
#Neutrophil remodeling is associated with human meibomian gland dysfunction and enables IFN-γ- and PAD4-dependent gland obstruction in mice biorxiv.org/content/10.648…
#Neutrophil remodeling is associated with human meibomian gland dysfunction and enables IFN-γ- and PAD4-dependent gland obstruction in mice biorxiv.org/content/10.648…
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Danny Saban retweeted
New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD.
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
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Danny Saban retweeted
Contradicting an influential 2023 study that claimed science progress has slowed and there is a notable decline in disruption, today's @Nature paper claims that's not true and was attributable to data artifacts
nature.com/articles/s4158…
economist.com/science-and-te…
nature.com/articles/s4158…
economist.com/science-and-te…
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Danny Saban retweeted
Academic biomedical research is national defence dlvr.it/TTtvVc
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