Richard Liu retweeted
@HarvardCCB is pleased to announce that leading chemist Jeffrey R. Long (Holm Lab alumnus) will be joining our department as the inaugural Thomas C. Foley Professor of Energy and the Environment: current.fas.harvard.edu/stories/leadin… #chemtwitter
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Richard Liu retweeted
Our study on discovering cooperative catalysis is in print @Nature! With @JacobsenLab @eugene_e_kwan @Merck @RichrdLiu we use simple math-based pooling/deconvolution to uncover useful catalyst combinations with minimal experiments
Read for free! rdcu.be/eN5i5
Read for free! rdcu.be/eN5i5
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In @NatureChemistry, we report reversible hydroxide emitters that generate highly basic (pH ~13) solns under light & revert to neutral in dark. The compounds, taking advantage of aromaticity effects, can directly capture/concentrate CO2 from ambient air. rdcu.be/eAB2S
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This work was led by Dr. Michael Purdy and Ariel Wang in our group. Congratulations! Critical spectroscopic & mechanistic insights were provided by our wonderful collaborators Dr. Matt Drummer and Prof. Dan Nocera - thank you for your contributions!
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Here's a fun photo of Michael capturing CO2 on the roof of Mallinckrodt labs in the Cambridge sunlight.
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Adding to the growing toolbox of aryl azide syntheses: From @Shangyu_Li on @ChemRxiv, Pd-catalyzed coupling of ArBr/ArOTf with NaN3. This reaction is trickier than it looks: as we show, [LPd-N3]2 dimers form with many L's & the pdt can inhibit Pd(0).
doi.org/10.26434/chemr…
doi.org/10.26434/chemr…
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@Shangyu_Li @ChemRxiv With no added base, the conditions leave NH and OH untouched.
It can be nice to have complementary approaches for making useful types of compounds 🔼🔽◀️▶️
It can be nice to have complementary approaches for making useful types of compounds 🔼🔽◀️▶️
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Our group reports a Ni-catalyzed desulfurative ring contraction method in @J_A_C_S.
By performing double SNAr reactions and "deleting" the sulfur atom afterwards, many fun heterocycles can be synthesized in 2 steps from commercial materials. Congratulations, @chou15_johnson!
By performing double SNAr reactions and "deleting" the sulfur atom afterwards, many fun heterocycles can be synthesized in 2 steps from commercial materials. Congratulations, @chou15_johnson!
Ni-Catalyzed Reductive Ring Contraction via Desulfurative Cross-Coupling | Journal of the American Chemical Society @TotalSyntheses @Harvard @HarvardCCB pubs.acs.org/doi/10.1021/ja…
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In Org. Lett. (@JOC_OL), Khash and Nathan report a simple, bench-stable, and recyclable organic reagent that quantitatively releases CO in solution upon blue-light irradiation. The method can be combined with carbonylative cross-coupling reactions.
doi.org/10.1021/acs.or…
doi.org/10.1021/acs.or…
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The revised & formatted version now in @angew_chem! doi.org/10.1002/anie.2…
Nathan, Dana, Breno expanded the study to show 10 examples of ArSFs (incl 2 crystal structures) & highlight the reactivity of this FG with alkenes, alkynes, and carbenes (uncatalyzed!)
Happy New Year!
Nathan, Dana, Breno expanded the study to show 10 examples of ArSFs (incl 2 crystal structures) & highlight the reactivity of this FG with alkenes, alkynes, and carbenes (uncatalyzed!)
Happy New Year!
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An expanded version of this work is now out in @J_A_C_S: doi.org/10.1021/jacs.4…
Many thanks to several fantastic reviewers who guided us to improve the study (incl discovery of a new ligand for less biased p-alkyl/aryl substrates). Happy Holidays!
Many thanks to several fantastic reviewers who guided us to improve the study (incl discovery of a new ligand for less biased p-alkyl/aryl substrates). Happy Holidays!
The next chapter of our metal catalysis work is now on @ChemRxiv. We report that an unusual reversible Pd "ring-walking" process can be used to access unconventional isomers of cross-coupling products!
doi.org/10.26434/chemr…
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This summer, our lab had the pleasure of having Mustafa M. from Brighton High School as a colleague. We appreciate your enthusiasm, humor, and contributions to our research!
Thanks also to Amelia and Ariel for serving as mentors 🧪⚗️
Thanks also to Amelia and Ariel for serving as mentors 🧪⚗️
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Richard Liu retweeted
How can design and synthesis overcome antibiotic resistance? Find out this week as Kelvin Wu (Myers group @HarvardCCB) shares his work on cresomysin recently published in @ScienceMagazine! Thanks to Reem for hosting/editing!
youtu.be/M9H8qCcDRqs
Ref: doi.org/10.1126/scienc…
youtu.be/M9H8qCcDRqs
Ref: doi.org/10.1126/scienc…
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Richard Liu retweeted
Aug is almost here, and the 2024 OM Bootcamp kicks off soon (Mon, Aug 12, 8 am PT) @ScrippsGradPrgm @scrippsresearch
• hybrid format
• open to all
• 2-week short course
• targeted to senior undergrads / early-stage grad students
Learn more: forms.gle/7dfJS5Nr7G3aEu…
• hybrid format
• open to all
• 2-week short course
• targeted to senior undergrads / early-stage grad students
Learn more: forms.gle/7dfJS5Nr7G3aEu…
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Richard Liu retweeted
Congratulations to @GabrielLovinger and Marcus Sak @msh_yi on their paper in @Nature! A HBD catalyst accelerates an SN2 pathway despite H-bonding to the nucleophile by preorganizing the ion pair into a reactive conformation, just like an enzyme would!
nature.com/articles/s4158…
nature.com/articles/s4158…
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Richard Liu retweeted
Caging Bioactive Triarylimidazoles: An Approach to Create Visible Light-Activatable Drugs | Journal of the American Chemical Society @HokkaidoUni #Caging #Bioactive #Triarylimidazoles #VisibleLight #Activation #Drugs pubs.acs.org/doi/10.1021/ja…
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Richard Liu retweeted
Congratulations to Prof Eric Jacobsen @JacobsenLab on receiving the 2024 Welch Award! @WelchFoundation welch1.org/news-reports/n… #chemtwitter
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Sharing some work on organic sulfenyl fluorides (R-S-F) in this preprint: go.shr.lc/4aTUeYh. R-SF3 and R-SF5 are well-known functional groups, so why do we never hear about their baby cousin R-SF? Would such a thing behave like R-SCl or R-SBr?
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It was thought such compounds disproportionate (by 3 RSF 🔜 RSF3 + RSSF) too rapidly to be isolated, but we found a few surprisingly stable examples. These undergo regio-/stereoselective fluorination rxns (and the SAr can be used more/removed after).
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