Discontinuation of Anticoagulant Therapy After Catheter Ablation for Atrial Fibrillation jamanetwork.com/journals/jama/…
0
0
0
50
Radosław Lenarczyk retweeted
Presented at #TCT2026:
In patients with moderate aortic stenosis and high-risk features, the percentage who died or had a heart-failure event within 2 years was lower with transcatheter aortic-valve replacement than with surveillance (16.7% vs. 23.9%). Full PROGRESS trial x6ThWHfV5
@crfheart
In patients with moderate aortic stenosis and high-risk features, the percentage who died or had a heart-failure event within 2 years was lower with transcatheter aortic-valve replacement than with surveillance (16.7% vs. 23.9%). Full PROGRESS trial x6ThWHfV5
@crfheart
8
113
312
597,001
Radosław Lenarczyk retweeted
Another sobering study in AF ablation. Melbourne group reports on 121 patients who have recurrent AF despite durable PVI. All have posterior wall isolation. [Because we can.]
The results are similar to the trials. Not good.
doi.org/10.1016/j.jace…
@peterkistler3
The results are similar to the trials. Not good.
doi.org/10.1016/j.jace…
@peterkistler3
15
19
69
19,429
Radosław Lenarczyk retweeted
Credit to the EP team in Bern for this excellent remapping study after either RF or PFA. Mandated remapping is much better than remapping for symptoms jacc.org/doi/10.1016/j.…
A) PFA no better than RF for durable PVI
B) Recapitulates GAP study showing that AF still occurs in one-third of durably isolated PVs and 72% of those with reconnected veins DID NOT have AF at one year
This is the crux of our problem in EP: we don't understand the pathophysiology of the condition. PVs get isolated because we can. @TobiasReichlin
A) PFA no better than RF for durable PVI
B) Recapitulates GAP study showing that AF still occurs in one-third of durably isolated PVs and 72% of those with reconnected veins DID NOT have AF at one year
This is the crux of our problem in EP: we don't understand the pathophysiology of the condition. PVs get isolated because we can. @TobiasReichlin
4
37
112
13,371
Radosław Lenarczyk retweeted
Interesting case of 2 times failed left sided AP; endocardially! nice double signals during VP; no early signal endo. but inside CS ; it was great and AP easily gone here👇! #Epeeps
3
2
38
2,089
Radosław Lenarczyk retweeted
Conduction System Recovery After Pulsed Field Ablation of a Para-Hisian PVC #OpenAccess
@DrMatthewHyman @PennEPFellows
heartrhythmjournal.com/article/S1547-…
@DrMatthewHyman @PennEPFellows
heartrhythmjournal.com/article/S1547-…
1
21
81
7,205
Radosław Lenarczyk retweeted
Wow. BREAKING.
Critical appraisal springs to life from Top People when they do not like the results
Read this scathing critique of PVI-SHAM-AF trial heartrhythmjournal.com/article/S1547-…
From many of the makers of endpoints like "non-procedural bleeding" and noninferiority without relative risk margins
My friends, put down those stones, you are going to break something in that glass house
Grin. Double Grin. Stay tuned to TWIC.
Critical appraisal springs to life from Top People when they do not like the results
Read this scathing critique of PVI-SHAM-AF trial heartrhythmjournal.com/article/S1547-…
From many of the makers of endpoints like "non-procedural bleeding" and noninferiority without relative risk margins
My friends, put down those stones, you are going to break something in that glass house
Grin. Double Grin. Stay tuned to TWIC.
5
10
60
25,018
In HF patients with refractory AF undergoing atrioventricular node ablation, CSP with left bundle branch area pacing was non-inferior to BVP for LVEF improvement at 6 months, providing comparable clinical outcomes and a favourable procedural profile ➡️the CONDUCT-AF trial👇 academic.oup.com/eurheartj/arti…
1
5
7
528
Radosław Lenarczyk retweeted
Para-His periaortic VT ablation with focal pulsed-field energy #OpenAccess
@PranavBhagirath @ivroca
heartrhythmjournal.com/article/S1547-…
@PranavBhagirath @ivroca
heartrhythmjournal.com/article/S1547-…
2
30
78
5,094
Radosław Lenarczyk retweeted
In patients with #AFib and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation. Full SINGLE-AF trial results and Research Summary: nej.md/4ii61XB
#ESCCongress
#ESCCongress
6
73
252
37,080
Radosław Lenarczyk retweeted
2026 HRS/EHRA scientific statement on pulsed field ablation for cardiac arrhythmias
heartrhythmjournal.com/article/S1547-…
heartrhythmjournal.com/article/S1547-…
0
40
127
9,957
Radosław Lenarczyk retweeted
The legal implications of medical AI, a review of 31 cases involving AI tools
nature.com/articles/s4436…
nature.com/articles/s4436…
10
68
195
29,349
A novel ECG algorithm for accurate localization of manifest accessory pathways in both children and adults: SMART-WPW-4 me, important features to differentiate right free wall vs right septal APs👇 heartrhythmjournal.com/article/S1547-…
0
0
1
113
Radosław Lenarczyk retweeted
Our meta-analysis of 7 RCTs (7,353 patients) found that pLAAO was associated with significantly more ischemic stroke or systemic embolism than OAC, without reducing major bleeding. Bayesian analysis also failed to establish noninferiority. Proponents of pLAAO will not like this nm @AndrewFoy82
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
5
8
44
12,036
Radosław Lenarczyk retweeted
These letters are the tip of the iceberg of the prob w CHAMPION (and OPTION, btw)
CHAMPION will be used in EBM classes as an eg of biased design and interpretation
A colossal embarrassment for the academics involved
Note what BSX stock did the Monday after the *positive* trial was presented
cc @kaulcsmc
CHAMPION will be used in EBM classes as an eg of biased design and interpretation
A colossal embarrassment for the academics involved
Note what BSX stock did the Monday after the *positive* trial was presented
cc @kaulcsmc
Published in the NEJM, three letters raise important points about CHAMPION-AF:
1) The primary endpoint includes cardiovascular death (42% of events), which is a “dilutive” component that does not characterize either treatment arm and favors a finding of noninferiority.
2) roke reveals a hazard ratio of 1.61 (95% CI, 1.00–2.59), with no difference in hemorrhagic stroke. This is somewhat the opposite of what one would expect from percutaneous LAAC.
3) The number of events was so much lower than anticipated that, while maintaining the same noninferiority margin, the trial effectively allowed a doubling of events while still declaring noninferiority.
4) It is inappropriate to consider the risk of intracranial hemorrhage solely as a function of oral anticoagulant exposure, while ignoring predisposing structural conditions such as cerebral amyloid angiopathy.
nejm.org/doi/full/10.10…
2
14
59
40,138
Radosław Lenarczyk retweeted
What makes a meta-analysis believable?
In our latest issue, a new Viewpoint outlines how to identify meta-analyses that merit clinical confidence.
Explore the full issue: spkl.io/60197rxth
In our latest issue, a new Viewpoint outlines how to identify meta-analyses that merit clinical confidence.
Explore the full issue: spkl.io/60197rxth
7
166
411
39,563
Radosław Lenarczyk retweeted
Premature ventricular contractions on healthy and diseased hearts: Differential acute effect of coupling interval and location
heartrhythmjournal.com/article/S1547-…
heartrhythmjournal.com/article/S1547-…
0
36
105
7,451
Radosław Lenarczyk retweeted
Incidence and predictors of major arrhythmic events after acute myocarditis complicated by ventricular arrhythmias: A systematic review and meta-analysis
@GuenanciaC
heartrhythmjournal.com/article/S1547-…
@GuenanciaC
heartrhythmjournal.com/article/S1547-…
1
8
15
2,181
Radosław Lenarczyk retweeted
LEAP2: A first-in-human evaluation of a chronically implanted novel leadless pacemaker for conduction system pacing #OpenAccess
heartrhythmjournal.com/article/S1547-…
heartrhythmjournal.com/article/S1547-…
0
28
60
9,558
Periodic repolarization dynamics (#PRD) combined with supraventricular premature complexes/hour showed better discrimination than the CHASE‐LESS score alone in predicting new #AF after stroke
ahajournals.org/doi/10.1161/JA…
⬇️
ahajournals.org/doi/10.1161/JA…
⬇️
0
2
7
767