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🔥 Beyond placebo!
Does AF ablation really improve quality of life?
Our meta-analysis of sham-controlled RCTs shows that with AF ablation:
✅ +13.5 AFEQT points
✅ 51% lower AF recurrence
✅ Benefit beyond active-treatment controls
....and this is with SHORT follow-up and an rol!
📖 Kakarla et al. Heart Rhythm, 2026. bit.ly/4iDdvnL
@Dr_Saikiran_K @Hidehiro_1986 @DrJasonAndrade @JonathanAriya @Mel_Gunawardene @nmarrouche @melissaemm1 @Elliott_AD @peterkistler3
#AtrialFibrillation #EP
#CHRD @HRSonline @thecsanz @hrs_journal
Does AF ablation really improve quality of life?
Our meta-analysis of sham-controlled RCTs shows that with AF ablation:
✅ +13.5 AFEQT points
✅ 51% lower AF recurrence
✅ Benefit beyond active-treatment controls
....and this is with SHORT follow-up and an rol!
📖 Kakarla et al. Heart Rhythm, 2026. bit.ly/4iDdvnL
@Dr_Saikiran_K @Hidehiro_1986 @DrJasonAndrade @JonathanAriya @Mel_Gunawardene @nmarrouche @melissaemm1 @Elliott_AD @peterkistler3
#AtrialFibrillation #EP
#CHRD @HRSonline @thecsanz @hrs_journal
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Prash Sanders retweeted
Proud of @MekhaelMario for leading this DECAAF-II analysis! Our findings echo @peterkistler3’s work on AF burden, with an important distinction: LA volume also independently predicted arrhythmia recurrence after PVI.
LA enlargement offers a window into atrial remodeling. In our cohort, larger atria had more fibrosis, suggesting more advanced structural disease—a substrate that may sustain #AFib despite #PVI
Understanding the underlying atrial disease is central to understanding ablation outcomes. Actual current priority focus of @TulaneHeart and @TulaneTriad @Phiso_de @chris_sohns @PrashSanders @gautamsand @S_NarayanMD @TinaBaykaner @Siddmann @drjohnm
LA enlargement offers a window into atrial remodeling. In our cohort, larger atria had more fibrosis, suggesting more advanced structural disease—a substrate that may sustain #AFib despite #PVI
Understanding the underlying atrial disease is central to understanding ablation outcomes. Actual current priority focus of @TulaneHeart and @TulaneTriad @Phiso_de @chris_sohns @PrashSanders @gautamsand @S_NarayanMD @TinaBaykaner @Siddmann @drjohnm
@peterkistler3 @DrJeremyWilliam Very interesting study! We found quite similar findings in our DECAAF-II subanalysis, where LA volume and AF burden were correlated with a similar R² of 0.12. However, we also found a significant difference in AF recurrence rates between patients with low versus high LA volumes.
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Prash Sanders retweeted
Confusing recommendation for AF ablation in HFrEF with multiple consistent RCTs for ABL vs drugs yet LOE C! #2026ESC HF guidelines. Has there been a GDMT study in AF & HFrEF popn NOT inc substudies or secondary analysis? @drjohnm @nmarrouche @chris_sohns @escardio
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Prash Sanders retweeted
Congratulations to the 2026 #APHRS organizers for an amazing international EP meeting in Busan with great content, expert faculty, and release of the first APHRS AF guidelines. Beautiful venue. Thank you for the wonderful hospitality. @ChoiEueKeun
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Prash Sanders retweeted
Very fitting to have a joint Physiologic Pacing session @APHRSOfficial with @NatRevCardiol in Busan, with #PPS10 in two short weeks.
Our review led by Drs. Lee & Choi @Hisdoc1 @Dr_JozaEP @lusty63 @Marek_Jastrz_EP @MdHuang @HaranBurri @shunmug_his_mdu now online in Nature!
nature.com/articles/s4156…
Our review led by Drs. Lee & Choi @Hisdoc1 @Dr_JozaEP @lusty63 @Marek_Jastrz_EP @MdHuang @HaranBurri @shunmug_his_mdu now online in Nature!
nature.com/articles/s4156…
New online! The evolution and future of conduction system pacing dlvr.it/TW1x1R
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Prash Sanders retweeted
Incredible! Congratulation to @APHRSOfficial and @KHRS_1997 on Busan 2026. #HealTheWorld #MichaelJackson
True bravery! APHRS EPs singing at faculty dinner #APHRS2026 @HuiNam_Pak #APHRS2026 not sure we’d see this in 🇦🇺?
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Prash Sanders retweeted
While slowly making my way home from #APHRS2026 in Busan South Korea I’ve been reflecting on the amazing week we’ve shared together. Our EP community is filled with so many amazing people pushing frontiers and making incredible discoveries that push our field forward. It often appening and it’s hard to keep up. Which is why it’s so important that meetings like APHRS bring us all together, to share in this information and showcase the incredible work that’s being done around the world. I’m honoured to take part in this incredible meeting and so happy that I was able to share this experience with old and new friends. This first trip to South Korea has been incredible and I look forward to many more.
@DilawriCVI @VCHResearch @CardioUBC
@DilawriCVI @VCHResearch @CardioUBC
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Prash Sanders retweeted
CATHETER ABLATION VERSUS SHAM FOR SYMPTOMATIC ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND BAYESIAN META-ANALYSIS OF RANDOMIZED TRIALS #OpenAccess
heartrhythmjournal.com/article/S1547-…
heartrhythmjournal.com/article/S1547-…
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Prash Sanders retweeted
Proud to be part of this work led by @PrashSanders . Pooling all 3 sham-controlled RCTs (SHAM-PVI, PFA-SHAM, PVI-SHAM-AF): AF ablation beats sham. QoL +13.5 AFEQT points, 94% probability of a clinically meaningful gain. #AFib recurrence cut in half (RR 0.49), 99% probability of benefit.@DrJasonAndrade @Mel_Gunawardene @peterkistler3 @lamajebbawi
CATHETER ABLATION VERSUS SHAM FOR SYMPTOMATIC ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND BAYESIAN META-ANALYSIS OF RANDOMIZED TRIALS #OpenAccess
heartrhythmjournal.com/article/S1547-…
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Prash Sanders retweeted
@PrashSanders @Dominik_Linz @DJ_Lakkireddy @atulverma_md @JonPicciniSr @True_EP @AndreaRussoEP @purerfellner @joselmerino @drrakeshg1 @Ed_Gerst Great news! The 17 years of ablation for symptomatic AF despite AAD that I was 100% sure worked at a minimum to improve QOL and reduce CHF and possibly SSE turns out not to be a wasted effort. Probably could have figured this out with patient testimonials. Love it. 😍
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Prash Sanders retweeted
Proud to have been part of this important collaboration.
As mentioned back in August when the results were presented at ESC - it’s always important to consider the evidence base and nuance within each trial.
Top line results don’t tell the whole story (see PIF-PAF) nor does one study mean we forget everything that came before it.
As mentioned back in August when the results were presented at ESC - it’s always important to consider the evidence base and nuance within each trial.
Top line results don’t tell the whole story (see PIF-PAF) nor does one study mean we forget everything that came before it.
🔥 Beyond placebo!
Does AF ablation really improve quality of life?
Our meta-analysis of sham-controlled RCTs shows that with AF ablation:
✅ +13.5 AFEQT points
✅ 51% lower AF recurrence
✅ Benefit beyond active-treatment controls
....and this is with SHORT follow-up and an rol!
📖 Kakarla et al. Heart Rhythm, 2026. bit.ly/4iDdvnL
@Dr_Saikiran_K @Hidehiro_1986 @DrJasonAndrade @JonathanAriya @Mel_Gunawardene @nmarrouche @melissaemm1 @Elliott_AD @peterkistler3
#AtrialFibrillation #EP
#CHRD @HRSonline @thecsanz @hrs_journal
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Prash Sanders retweeted
@PrashSanders Honestly that is true and moving the needle in this fascinating field takes a lot of effort and dedication and you truly have done it. Thank you so much
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Prash Sanders retweeted
Dr Prash Sanders, who has revolutionized many areas in EP at APHRS 2026 Busan
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What happens when clinicians, industry, engineers and regulators come together in the same room?
👉 Explore the HRX Live 2026 Impact Report: experiencehrx.com/hrx-live-2026-…
SAVE THE DATE!
HRX Live 2027 | September 17-19, 2027 | Gaylord Texan, Dallas
A Heart Rhythm Society (@HRSonline) 27 Producers: Dr. Prashanthan Sanders (@PrashSanders) and Dr. Devi Nair (@Drdevignair)
HRX Live 2027 Production Team: Tina Baykaner (@TinaBaykaner) , Jacqueline Joza, Bradley Knight (@DrBradleyKnight), Dominik Linz (@Dominik_Linz), Mike Lloyd (@MLloyd_emory), Melissa Middeldorp (@melissaemm1), Pasquale Santangeli (@Dr_Santangeli), Deepthy Varghese (@np_varghese)
#HRXLive #HRX2027 #Electrophysiology #CardiologyInnovation #MedTech #DigitalHealth #EPeeps #EPInnovation #Cardiology
#HRX2026 #EPInnovation #Cardiology #DigitalHealth #EPeeps
👉 Explore the HRX Live 2026 Impact Report: experiencehrx.com/hrx-live-2026-…
SAVE THE DATE!
HRX Live 2027 | September 17-19, 2027 | Gaylord Texan, Dallas
A Heart Rhythm Society (@HRSonline) 27 Producers: Dr. Prashanthan Sanders (@PrashSanders) and Dr. Devi Nair (@Drdevignair)
HRX Live 2027 Production Team: Tina Baykaner (@TinaBaykaner) , Jacqueline Joza, Bradley Knight (@DrBradleyKnight), Dominik Linz (@Dominik_Linz), Mike Lloyd (@MLloyd_emory), Melissa Middeldorp (@melissaemm1), Pasquale Santangeli (@Dr_Santangeli), Deepthy Varghese (@np_varghese)
#HRXLive #HRX2027 #Electrophysiology #CardiologyInnovation #MedTech #DigitalHealth #EPeeps #EPInnovation #Cardiology
#HRX2026 #EPInnovation #Cardiology #DigitalHealth #EPeeps
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Prash Sanders retweeted
How has this post only got 414 views?
Anyway, do yourself a favour and read it.
Their link doesn’t work, so here it is:
nature.com/articles/s4156…
This:
CSP followed by atrioventricular node ablation is an effective rate-control strategy in atrial fibrillation, offering ventricular synchrony and haemodynamic benefit similar to that from conventional biventricular pacing.
Anyway, do yourself a favour and read it.
Their link doesn’t work, so here it is:
nature.com/articles/s4156…
This:
CSP followed by atrioventricular node ablation is an effective rate-control strategy in atrial fibrillation, offering ventricular synchrony and haemodynamic benefit similar to that from conventional biventricular pacing.
New online! The evolution and future of conduction system pacing dlvr.it/TW1x1R
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Prash Sanders retweeted
Durability of pulmonary vein isolation: Does the pulsed field ablation system matter? buff.ly/7Tb3BWg @PrashSanders 'The balloon-in-basket PFA platform demonstrated significantly greater chronic PVI durability than the pentaspline system. '
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Prash Sanders retweeted
Cardiac Electrophysiology at a Crossroads: Building on Dr. Josephson's 20 years of observations. Is EP science, procedure or both? What is the future of EP science?
authors.elsevier.com/a/1nzSl,siTgsT…
#EPeeps #CardioX @ACCinTouch @HRSonline
authors.elsevier.com/a/1nzSl,siTgsT…
#EPeeps #CardioX @ACCinTouch @HRSonline
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