Pinned Tweet
Really excited to have our story on a CYP17A1-independent androgen biosynthesis pathway out today! We think this could be a reason for why androgens are left with abiraterone tx in prostate cancer. @dsui_miami_uro @SylvesterCancer @PCFnews @ASCO @AACR rdcu.be/eS7kU
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Nima Sharifi retweeted
Going to mention this finding to all my low T consults who want to “optimize” their levels for “wellness” and “longevity”
If they dared, biohacking bros who seek to defy aging could try a simple, time-tested method: castration.
Removing the testicles extends male life span across many mammalian species, including humans. But a research team exploring this effect has now found the surgical procedure ormed early in life to boost longevity, as scientists had assumed.
In a new preprint, the group reports that neutering older male mice lengthens their lives by more than 30%, upending prevailing ideas of how the testes influence aging.
Learn more: scim.ag/4zs7KPX @NewsfromScience
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Nima Sharifi retweeted
Thrilled to share updated results from JNJ-6143, the AR-BRD4 RIPTAC therapy, presented by @BGarmezy. Totally novel MOA was well tolerated, oral pill and produced significant benefit for pts (PSA90 50%, ORR 68%). P2 trial active now and more coming. Lots of potential!
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Superb achievements by @ZhipengA and @BitarafMasoudMD! @AmerUrological @ASCO news.med.miami.edu/prostate-cance…
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Nima Sharifi retweeted
Exciting opportunity for Urology & med onc trainees and practicing physicians👉Elevate your clinical and leadership skills at the @PCFnews Leadership Academy! 📍Santa Monica | Dec 3–5, 2026
✅ Expert faculty mentoring ✅ Formal certification
✅ Travel & hotel covered 👉Apply: https://ay
✅ Expert faculty mentoring ✅ Formal certification
✅ Travel & hotel covered 👉Apply: https://ay
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Nima Sharifi retweeted
Postdoc Hiring! Our lab at the University of Miami uses chemical biology and chemoproteomics to study metabolism-mediated PTMs in cancer and aging. Applicants with chemistry, biology, or medical backgrounds are welcome!
zawanglab.com
zawanglab.com
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Nima Sharifi retweeted
Ever wonder if tRNAs can regulate the identity of a cancer cell?
@HsiehLab @fredhutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s4158…
@HsiehLab @fredhutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s4158…
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Nima Sharifi retweeted
Thrilled to share that I’ve been awarded a prestigious @PCFnews Young Investigator Award! Big thanks to my mentors Drs. Taplin and Haffner, and highest gratitude to @NimaSharifiMD whose guidance made this possible.
@dsui_miami_uro @umiamimedicine
#PCFRetreat26
@urotoday
@dsui_miami_uro @umiamimedicine
#PCFRetreat26
@urotoday
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Big congratulations to @BitarafMasoudMD on being awarded a @PCFnews Young Investigator Award at #PCF2026! So well deserved! @dsui_miami_uro @SylvesterCancer @umiamimedicine @urotoday
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Nima Sharifi retweeted
How many scientists study #ProstateCancer because of Howard Soule?
How many collaborations originated with an intro from Howard?
How many lives have been touched by this wonderful man?
Thank you, Howard!
@PCF_Science tribute to Howard!
#PCFRetreat26
How many collaborations originated with an intro from Howard?
How many lives have been touched by this wonderful man?
Thank you, Howard!
@PCF_Science tribute to Howard!
#PCFRetreat26
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Nima Sharifi retweeted
Thought provoking discussion on the androgen to GC relationship and role for 11BHSD by @NimaSharifiMD who continues to push this field forward
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Nima Sharifi retweeted
In the @PCF_Science #PCFretreat26 , @NimaSharifiMD presents his team’s groundbreaking work on steroid metabolism as MOA 👇underlying resistance to AR signaling 👉@PCF_Science @urotoday @SylvesterCancer @dsui_miami_uro
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“In the hormone therapy subgroup, the CC genotype was significantly associated with increased PCSM among patients with metastatic (HR=6.79, 95% CI: 2.03-17.2, P<0.001) and advanced (HR=3.29, 95% CI: 1.10-11.7, P=0.03) disease.” @AACR #HSD3B1 aacrjournals.org/cancerres/arti…
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From Pittsburgh to Miami for @CarnegieMellon! Just incredible! cnbc.com/2026/09/30/ken…
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Nima Sharifi retweeted
@nc_frey Finding candidates is relatively straightforward, with or without Claude. Extensive experimental validation and rigorous peer review are the hard parts. For context, see Fanzor, Cas13an, and our TM184C work:
doi.org/10.1038/s41586…
doi.org/10.1126/scienc…
doi.org/10.1038/s41586…
doi.org/10.1038/s41586…
doi.org/10.1126/scienc…
doi.org/10.1038/s41586…
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Nima Sharifi retweeted
I’d do it all again and would encourage anyone interested! There’s no shortage of med school applications. It is still a noble profession
To whom it may concern,
63% physicians do not want their children to pursue a career in medicine.
This number is even higher among younger physicians.
Medicine is no longer the noble profession it once was.
Corporate greed poses an existential threat to the practice of medicine.
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Nima Sharifi retweeted
Ever wonder how heterogeneity defines bladder cancer subtypes?
Ha and Hsieh Lab postdoctoral fellows @pushpa_itagi and Samantha Schuster @fredhutch did, leading to a deep study of bladder cancer clonality, evolution, and heterogeneity published @Nature
nature.com/articles/s4158…
Ha and Hsieh Lab postdoctoral fellows @pushpa_itagi and Samantha Schuster @fredhutch did, leading to a deep study of bladder cancer clonality, evolution, and heterogeneity published @Nature
nature.com/articles/s4158…
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Nima Sharifi retweeted
Out online today in @Nature. The known protein universe holds hundreds of millions of members, yet most remain unexplored, a vast biological darkness that may hold important clues to human health and disease. We went looking in it.
doi.org/10.1038/s41586…
doi.org/10.1038/s41586…
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Nima Sharifi retweeted
New study with our amazing partners showing calorie restriction reduces aging associated mutation accumulation in mice is out in @CellCellPress.
While lots of interventions increase mutations, here we show CR can actually slow normal aging-associated mutations genome-wide!
Remarkable linkage between diet, genomic integrity, and lifespan.
Interestingly, benefits were not uniformly distributed across the genome.
cell.com/cell/abstract/…
Led by @ShoagLab @giladevrony @VickyAcostaR @CircadianClocks @GronskaPeski @greenlab_utsw
cc @PeterAttiaMD @NirBarzilaiMD @agingdoc1 @aubreydegrey @CharlesMBrenner @mkaeberlein @davidasinclair @UH_RE_Institute @caseccc @CaseUrology
While lots of interventions increase mutations, here we show CR can actually slow normal aging-associated mutations genome-wide!
Remarkable linkage between diet, genomic integrity, and lifespan.
Interestingly, benefits were not uniformly distributed across the genome.
cell.com/cell/abstract/…
Led by @ShoagLab @giladevrony @VickyAcostaR @CircadianClocks @GronskaPeski @greenlab_utsw
cc @PeterAttiaMD @NirBarzilaiMD @agingdoc1 @aubreydegrey @CharlesMBrenner @mkaeberlein @davidasinclair @UH_RE_Institute @caseccc @CaseUrology
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Never too old to be a mentor nor too young to be a mentee. The 92-Year-Old Mathematician and the Teenage Apprentice nytimes.com/2026/09/06/sci… via @NYTimes
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