It’s a special day @MSKCancerCenter. We honor David Rubenstein Awardee Marina Pasca di Magliano @Pasca_Lab @UMRogelCancer. Marina is a brilliant scientist who lights the way for our field, and a treasured mentor + colleague to so many. Congrats Marina + her team! 💜
2
9
69
2,800
Mara Sherman Lab retweeted
Are you passionate about metastasis and interested in starting your laboratory here @FredHutch_Met_X? Here's your opportunity - deadline's on Monday!!!
nature.com/naturecareers/…
nature.com/naturecareers/…
0
6
13
940
Mara Sherman Lab retweeted
Our @Nature paper is out!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s4158…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s4158…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
11
56
301
32,500
Mara Sherman Lab retweeted
So honored to join this club and to know my peers value my impact. But the celebration and honor is even bigger knowing I join together with @rosslevinemd , our CSO whose impact on medicine is truly great.
We're proud to share that Dr. Ross Levine, Chief Scientific Officer at MSK and Dr. @dana_peer, Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute (SKI) at MSK, have been elected to the @theNAMedicine.
With these latest appointments, 30 MSK w received this prestigious honor.
Learn more about these two elections: bit.ly/3VWdHWq
7
2
110
4,534
Mara Sherman Lab retweeted
There is an opening for a postdoc in my laboratory. The aim of the post is to develop and use novel methodologies for mass spectrometry and phosphoproteomics analysis in complex multicellular environments. cruk.manchester.ac.uk/career/mi-26-5…
0
8
6
625
Mara Sherman Lab retweeted
1/ Most genes and variants matter somewhere but look silent in any one cell model. Can we build conditions that reveal phenotypes? With @kanishkadey, we engineer cell states to expose hidden disease biology and trace how genetic risk reaches disease genes. biorxiv.org/content/10.648…
7
114
407
56,270
Mara Sherman Lab retweeted
🎉Our paper on #PDAC and #Pancreatitis organoid multistroma #cocultures is on the cover of @NatureCellBio! Congratulations to the whole lab!!
Almost 10 years (🤯) after my postdoc paper in @JExpMed, here we are again!! So poetic!
nature.com/articles/s4155…
Almost 10 years (🤯) after my postdoc paper in @JExpMed, here we are again!! So poetic!
nature.com/articles/s4155…
5
11
69
3,622
Mara Sherman Lab retweeted
After many years of effort, deliberation, excitement, angst, joy, and Wednesday afternoon lab lunches, our group's first manuscript on cachexia, led by Venise Jan Castillon, Amy Xie, and really our whole lab nature.com/articles/s4159… @NatureMedicine
9
42
128
15,744
Mara Sherman Lab retweeted
💡 What sets the size of a germinal center? — why lymphatics of course 😉
Our new study with Carla Nowosad reveals how lymphatic remodeling constrains germinal center growth and shapes the quality of the antibody response. @ImmunityCP @nyugrossman
cell.com/immunity/fullt…
Our new study with Carla Nowosad reveals how lymphatic remodeling constrains germinal center growth and shapes the quality of the antibody response. @ImmunityCP @nyugrossman
cell.com/immunity/fullt…
2
22
99
7,031
Mara Sherman Lab retweeted
Meet #MSKPostdoc Marc Nater (@MarcNtr) from the @MaraShermanLab. Marc studies how pancreatic cancer hijacks surrounding supporting cells to spread and resist treatment.
#NPAW2026 🇨🇭
@MSKPDA
#NPAW2026 🇨🇭
@MSKPDA
1
2
2
434
Mara Sherman Lab retweeted
Very happy to share our new paper in Nature Cancer. This project started with a simple question: what drives the early loss of adipose tissue during pancreatic cancer cachexia?
3
7
58
5,405
Mara Sherman Lab retweeted
Great collaboration with @CentralParkWMD @MarcHilmi @EileenMOReilly @ciacobu @schoenfeld_j
@MckerrowWilson & an incredible team 👇👇👇
biorxiv.org/content/10.648…
The broader immunologic point from this work is the distinction between systemic activation and tissue-effective immunity. Neoantigen recognition by specific T-cell receptor, clonal expansion and spatial context all matter and the tumor ecosystem can determine whether a T-cell response becomes effective. From studies like this we will learning more about the fundamental rules of T-cell engagement in cancer and how to translate for precision immunotherapies, such as cancer vaccines, to help more patients.
@MSKCancerCenter
@MckerrowWilson & an incredible team 👇👇👇
biorxiv.org/content/10.648…
The broader immunologic point from this work is the distinction between systemic activation and tissue-effective immunity. Neoantigen recognition by specific T-cell receptor, clonal expansion and spatial context all matter and the tumor ecosystem can determine whether a T-cell response becomes effective. From studies like this we will learning more about the fundamental rules of T-cell engagement in cancer and how to translate for precision immunotherapies, such as cancer vaccines, to help more patients.
@MSKCancerCenter
@MarcHilmi @schoenfeld_je@EileenMOReillyc@CatherineaOCu@MichaelMayMDo@KevinCSoaresMDe@MaraShermanLab @xrtGenomicss@bengrbmm@FiyinfoluBS@MSK_DeptOfMede@MSKCancerCentert@CpcrMskd resistance when that engagement is blocked.
Incredibly proud of @MarcHilmi for leading this work and grateful to @EileenMOReilly @ciacobu and the entire David M. Rubenstein committee @CpcrMsk @MSKCancerCenter for creating the environment wh@MarcHilmiind of deeply intepossible and to Ben Greenbaum @bengrbm Josh Schoenfeld @schoenfeld_j Wilson Mckerrow @MckerrowWilson and our entire sPARK lab team for building this together. 🙏
sparklaboratory.org
This is what collaborative pancreatic cancer science 🧬🔬can uncover. And now we have a clearer roadmap 🚗🗺️ for what comes next.
#cancer #immunotherapy #PancreaticCancer #ICI #BRCA #HRD #3episodes @PanCAN @Pankind_Aus @NatPancFdn @lustgartenfdn @letswinpc @oncodaily @OncoDailyGI @OncoAlert @OncBrothers @brunolarvol @MSKCancerCenter @MSK_DeptOfMed @CpcrMsk
1
4
17
1,476
Mara Sherman Lab retweeted
🧵 1/10 The arc: POLAR - MDF – TIE
Pancreatic cancer is profoundly resistant to immune checkpoint inhibitors.
Yet, POLAR (pembrolizumab plus olaparib) trial showed that a subset of patients, especially with HRD (gBRCA2/1m or gPALB2m) tumors, can achieve remarkably durable to two questions:
#1 👆🏼what makes these tumors immunogenic?
#2 ✌️what makes that immunity actually work?
👑 #2. POLAR TIE @biorxivpreprint
biorxiv.org/content/10.648…
#1. MDF biorxiv.org/content/10.648…
#0. POLAR @NatureMedicine nature.com/articles/s4159…
#cancer #immunotherapy #PancreaticCancer #ICI #BRCA #HRD #3episodes @MSKCancerCenter @MSK_DeptOfMed @CpcrMsk @ldiaz1971 @debschrag
@PanCAN @oncodaily @OncoDailyGI @OncoAlert @OncBrothers @brunolarvol
Pancreatic cancer is profoundly resistant to immune checkpoint inhibitors.
Yet, POLAR (pembrolizumab plus olaparib) trial showed that a subset of patients, especially with HRD (gBRCA2/1m or gPALB2m) tumors, can achieve remarkably durable to two questions:
#1 👆🏼what makes these tumors immunogenic?
#2 ✌️what makes that immunity actually work?
👑 #2. POLAR TIE @biorxivpreprint
biorxiv.org/content/10.648…
#1. MDF biorxiv.org/content/10.648…
#0. POLAR @NatureMedicine nature.com/articles/s4159…
#cancer #immunotherapy #PancreaticCancer #ICI #BRCA #HRD #3episodes @MSKCancerCenter @MSK_DeptOfMed @CpcrMsk @ldiaz1971 @debschrag
@PanCAN @oncodaily @OncoDailyGI @OncoAlert @OncBrothers @brunolarvol
8
44
90
8,607
Mara Sherman Lab retweeted
Pancreatic tumors are highly heterogeneous and immunosuppressive. But is immune resistance imposed across the whole tumor - or built locally by distinct cancer-cell states?
I’m incredibly excited to share our new paper, now out in @Nature! 🎉
doi.org/10.1038/s41586…
(1/7)
I’m incredibly excited to share our new paper, now out in @Nature! 🎉
doi.org/10.1038/s41586…
(1/7)
10
71
338
34,763
Mara Sherman Lab retweeted
Three years ago, my lab at @MSKCancerCenter set out to see if we could harness AI for new therapeutic proteins.
Today in @natBME, our first step in developing these AI-designed molecules as anti-tumor therapies is online.
Read more here: 1/n mskcc.org/news/using-ai-…
Today in @natBME, our first step in developing these AI-designed molecules as anti-tumor therapies is online.
Read more here: 1/n mskcc.org/news/using-ai-…
10
57
217
15,628
In inflammation and cancer, mesenchymal heterogeneity begets epithelial heterogeneity. Beautiful new study from the Biffi lab - congratulations! ✨
🥳Happy to share our latest manuscript - out today in @NatureCellBio.
💜 Congrats and thanks to @Wenlong_Li1 and @Munta04, the whole lab, our collaborators and the funders that supported this important and beautiful 🤩 work!
Hope you enjoy the read!
nature.com/articles/s4155…
0
0
9
1,270
Mara Sherman Lab retweeted
The Maitra Lab @nyulangone @Perlmutter_CC is recruiting for a research scientist, with immediate availability. Please see the announcement below.
We are excited to grow our #PancreaticCancer research team as we approach the one year mark in NYC!
We are excited to grow our #PancreaticCancer research team as we approach the one year mark in NYC!
1
23
87
10,993
Neural niches are recurrent features of human cancer that may relay signals to nearby cells, to the immune system, + to the brain. So what’s in these niches, and what happens when cancer cells barge in? We take a look under the hood in our new preprint 1/ biorxiv.org/content/10.648…
7
30
111
10,788
@sylvie_deborde @MSKCancerCenter We did RCTD to compare across datasets and identified conserved features of invaded vs non-invaded perineural niches, including fibroblast and macrophage states associated w PNI and the presence of lymphoid aggregates only in the non-invaded setting 7/
1
0
0
514
@sylvie_deborde @MSKCancerCenter Finally, we were not the 1st to have this idea! Pls see this awesome study by @ZeminZhangLab. We took v different approaches to tissue collection and analysis, yielding distinct yet complementary findings 👍: cell.com/cancer-cell/fu…
1
0
2
338