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Hornstein Lab@HornsteinLab
1 Feb 2024
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐—ก๐—ข๐—ฉ๐—” (๐—กeuronal ๐—ขrganellomics ๐—ฉision ๐—”tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology
biorxiv.org/content/10.110โ€ฆ
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Yehuda M. Danino@DaninoYehuda
20 Oct 2025
Hi friends!๐Ÿ˜Ž I'm excited to share that after 7 amazing yrs as a PhD student and postdoc at @HornsteinLab, I'm starting my next chapter as a formal postdoc in @rolls_asya's lab @TelAvivUni. I'll be exploring systems #Cancer #Neuroscience using diverse cool TC and mouse models๐Ÿ๐Ÿฆ€
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Hornstein Lab@HornsteinLab
21 Oct 2025
Replying to @DaninoYehuda
@DaninoYehuda @rolls_asya @TelAvivUni Good luck Yehuda, you will be highly missed and we wish you much success in Rolls lab
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Hornstein Lab retweeted
Alzforum@alzforum
24 Sep 2025
TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine ow.ly/thRc50X1sgM
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Igor Ulitsky@IgorUlitsky
2 Sep 2025
Busy times ahead. I apologize in advance for potentially taking longer to respond to e-mails for a few years...
Weizmann Institute
@WeizmannScience
2 Sep 2025
Congratulations to Prof. @IgorUlitsky of the Department of Immunology and Regenerative Biology, upon being appointed as the new Dean of the Faculty of Biology. Prof. Ulitsky will assume his role on December 1, 2025
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Hornstein Lab@HornsteinLab
2 Sep 2025
Replying to @IgorUlitsky
@IgorUlitsky Huge congratulations! ๐ŸŽ‰
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ALS News Today
@alsnewstoday
12 Aug 2025
Wearable robot gives ALS patients a hand buff.ly/BTxGLnp

#ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch
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medRxiv@medrxivpreprint
12 May 2025
IsomiR Utility in ALS Prognostication medrxiv.org/cgi/content/shโ€ฆ #medRxiv
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Leeat Keren@leeat_keren
25 Mar 2025
Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!
Nature Biotechnology
@NatureBiotech
25 Mar 2025
High-dimensional imaging using combinatorial channel multiplexing and deep learning go.nature.com/4hGPfO0
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Hornstein Lab retweeted
Richard Sever@cshperspectives
11 Mar 2025
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] openrxiv.org 1/n
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Hornstein Lab@HornsteinLab
10 Mar 2025
Excited to share our preprint: "๐Ž๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐จ๐ฆ๐ข๐œ๐ฌ: ๐€๐ˆ-๐๐ซ๐ข๐ฏ๐ž๐ง ๐๐ž๐ž๐ฉ ๐จ๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐š๐ซ ๐ฉ๐ก๐ž๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐  ๐ซ๐ž๐ฏ๐ž๐š๐ฅ๐ฌ ๐ง๐จ๐ฏ๐ž๐ฅ ๐€๐‹๐’ ๐ฆ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐š๐ง ๐ง๐ž๐ฎ๐ซ๐จ๐ง๐ฌ"
Nancy Yacovzada@NancyYaco
10 Mar 2025
๐Ÿš€๐•๐ข๐ฌ๐ข๐จ๐ง-๐ญ๐ซ๐š๐ง๐ฌ๐Ÿ๐จ๐ซ๐ฆ๐ฌ-๐›๐š๐ฌ๐ž๐ ๐จ๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐š๐ซ ๐ฉ๐ก๐ž๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐  ๐ฎ๐ง๐ฏ๐ž๐ข๐ฅ๐ฌ ๐ก๐ข๐๐๐ž๐ง ๐€๐‹๐’ ๐ฆ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ!

๐Ÿงต Thread on ๐˜•๐˜–๐˜๐˜ˆ (๐˜•๐˜ฆ๐˜ถ๐˜ณ๐˜ฐ๐˜ฏ๐˜ข๐˜ญ ๐˜–๐˜ณ๐˜จ๐˜ข๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ฐ๐˜ฎ๐˜ช๐˜ค๐˜ด ๐˜๐˜ช๐˜ด๐˜ช๐˜ฐ๐˜ฏ ๐˜ˆ๐˜ต๐˜ญ๐˜ข๐˜ด)๐ŸŽ—๏ธ our deep-learning model trained with ~3M images of human-derived neurons, and newly discovered insights into ALS disease. We used AI to map cellular dysfunction at un unprecedented resolution, comprehensively studying all sub-cellular organelles.

Preprint: "๐Ž๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐จ๐ฆ๐ข๐œ๐ฌ: ๐€๐ˆ-๐๐ซ๐ข๐ฏ๐ž๐ง ๐๐ž๐ž๐ฉ ๐จ๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐š๐ซ ๐ฉ๐ก๐ž๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐  ๐ซ๐ž๐ฏ๐ž๐š๐ฅ๐ฌ ๐ง๐จ๐ฏ๐ž๐ฅ ๐€๐‹๐’ ๐ฆ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐š๐ง ๐ง๐ž๐ฎ๐ซ๐จ๐ง๐ฌ"
biorxiv.org/content/10.110โ€ฆ

Check out our code and data: github.com/Sagykri/NOVA
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Hornstein Lab retweeted
Neville Sanjana@nevillesanjana
26 Nov 2024
Delighted to share new work from our lab:
MultiPerturb-seq ๐ŸŽ›๏ธโŒ๐Ÿ“ฅ๐Ÿ“ค

Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Nature Biotechnology
@NatureBiotech
21 Nov 2024
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O
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Hornstein Lab retweeted
Hรผseyin Dogru
@hussedogru__
1 Oct 2024
The pure joy in Gaza as Iranian missiles cover the sky above Tel Aviv.
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Hornstein Lab retweeted
Alzforum@alzforum
9 Aug 2024
At AAIC 2024, phospho-tau assays look ready for primary and secondary care. @lunduniversity @wustl @BannerAlzheimer ow.ly/QPzg50SV3Tp
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medRxiv@medrxivpreprint
1 Aug 2024
A phase Ib/IIa study of Enoxacin in patients with ALS medrxiv.org/cgi/content/shโ€ฆ #medRxiv
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Hornstein Lab@HornsteinLab
2 Aug 2024
Replying to @HornsteinLab
@medrxivpreprint Plasma and CSF throughout the entire treatment period of 30 days, supporting the use of microRNAs as a pharmacodynamic marker of target engagement. These results enocurage larger and longer trials to test Enoxacin efficacy in patients with #ALS.
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Hornstein Lab@HornsteinLab
2 Aug 2024
Replying to @HornsteinLab
@medrxivpreprint This work is based on a pre-clinical study from the lab, by PhD student Dr. Anna Emde in @EMBO: embopress.org/doi/full/10.15โ€ฆ, and was performed in close collaboration with Dr. Angela Genge from @TheNeuro_MNI who ran the clinical trial.
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Hornstein Lab retweeted
medRxiv@medrxivpreprint
1 Aug 2024
A phase Ib/IIa study of Enoxacin in patients with ALS medrxiv.org/cgi/content/shโ€ฆ #medRxiv
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Hornstein Lab retweeted
Rahul Satija@satijalab
25 Jun 2024
Interested in 3' UTR changes in scRNA-seq? Check out our:
* CPA-Perturb-seq paper
* UCSC Perturb-seq tracks (see who regulates your favorite 3โ€™ UTR!)
* Seurat extension for polyA site analysis (PASTA)
* Deep neural perturbation network (APARENT-Perturb)
cell.com/cell/fulltext/โ€ฆ
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Slava Bobrov
@slava__bobrov
27 Mar 2024
Birth of a neuron. Stem cell transforming into a brain cell:

#neuroscience
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Hornstein Lab retweeted
Slava Bobrov
@slava__bobrov
16 May 2024
Human brain anatomy:

#neuroscience
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Hornstein Lab retweeted
Nancy Yacovzada@NancyYaco
18 Mar 2024
My team is working with a substantial arsenal of ML algorithms, analyzing diverse human molecular data. The most intriguing work imaginable. We do science and study human brain diseases, but like a small startup.
Come join us!
Hornstein Lab@HornsteinLab
18 Mar 2024
We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration.

Position details and requirements: machinelearning.co.il/job/biomedicalโ€ฆ

CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il

#jobopportunity
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Hornstein Lab@HornsteinLab
18 Mar 2024
We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration.

Position details and requirements: machinelearning.co.il/job/biomedicalโ€ฆ

CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il

#jobopportunity
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