Pinned Tweet
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐ก๐ข๐ฉ๐ (๐กeuronal ๐ขrganellomics ๐ฉision ๐tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology
biorxiv.org/content/10.110โฆ
biorxiv.org/content/10.110โฆ
9
22
77
11,850
Hornstein Lab retweeted
TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine ow.ly/thRc50X1sgM
0
6
13
1,198
Hornstein Lab retweeted
Wearable robot gives ALS patients a hand buff.ly/BTxGLnp
#ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch
#ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch
1
3
4
387
Hornstein Lab retweeted
IsomiR Utility in ALS Prognostication medrxiv.org/cgi/content/shโฆ #medRxiv
0
1
1
390
Hornstein Lab retweeted
Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!
High-dimensional imaging using combinatorial channel multiplexing and deep learning go.nature.com/4hGPfO0
15
38
172
19,253
Hornstein Lab retweeted
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] openrxiv.org 1/n
11
173
500
67,975
Excited to share our preprint: "๐๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐จ๐ฆ๐ข๐๐ฌ: ๐๐-๐๐ซ๐ข๐ฏ๐๐ง ๐๐๐๐ฉ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ซ๐๐ฏ๐๐๐ฅ๐ฌ ๐ง๐จ๐ฏ๐๐ฅ ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐๐ง ๐ง๐๐ฎ๐ซ๐จ๐ง๐ฌ"
๐๐๐ข๐ฌ๐ข๐จ๐ง-๐ญ๐ซ๐๐ง๐ฌ๐๐จ๐ซ๐ฆ๐ฌ-๐๐๐ฌ๐๐ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ฎ๐ง๐ฏ๐๐ข๐ฅ๐ฌ ๐ก๐ข๐๐๐๐ง ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ!
๐งต Thread on ๐๐๐๐ (๐๐ฆ๐ถ๐ณ๐ฐ๐ฏ๐ข๐ญ ๐๐ณ๐จ๐ข๐ฏ๐ฆ๐ญ๐ญ๐ฐ๐ฎ๐ช๐ค๐ด ๐๐ช๐ด๐ช๐ฐ๐ฏ ๐๐ต๐ญ๐ข๐ด)๐๏ธ our deep-learning model trained with ~3M images of human-derived neurons, and newly discovered insights into ALS disease. We used AI to map cellular dysfunction at un unprecedented resolution, comprehensively studying all sub-cellular organelles.
Preprint: "๐๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐จ๐ฆ๐ข๐๐ฌ: ๐๐-๐๐ซ๐ข๐ฏ๐๐ง ๐๐๐๐ฉ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ซ๐๐ฏ๐๐๐ฅ๐ฌ ๐ง๐จ๐ฏ๐๐ฅ ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐๐ง ๐ง๐๐ฎ๐ซ๐จ๐ง๐ฌ"
biorxiv.org/content/10.110โฆ
Check out our code and data: github.com/Sagykri/NOVA
1/n
1
6
29
1,976
Hornstein Lab retweeted
Delighted to share new work from our lab:
MultiPerturb-seq ๐๏ธโ๐ฅ๐ค
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
MultiPerturb-seq ๐๏ธโ๐ฅ๐ค
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O
5
57
286
54,380
Hornstein Lab retweeted
The pure joy in Gaza as Iranian missiles cover the sky above Tel Aviv.
1,634
10,924
77,293
5,677,856
Hornstein Lab retweeted
At AAIC 2024, phospho-tau assays look ready for primary and secondary care. @lunduniversity @wustl @BannerAlzheimer ow.ly/QPzg50SV3Tp
1
3
13
2,035
Hornstein Lab retweeted
A phase Ib/IIa study of Enoxacin in patients with ALS medrxiv.org/cgi/content/shโฆ #medRxiv
1
1
6
435
Hornstein Lab retweeted
Interested in 3' UTR changes in scRNA-seq? Check out our:
* CPA-Perturb-seq paper
* UCSC Perturb-seq tracks (see who regulates your favorite 3โ UTR!)
* Seurat extension for polyA site analysis (PASTA)
* Deep neural perturbation network (APARENT-Perturb)
cell.com/cell/fulltext/โฆ
* CPA-Perturb-seq paper
* UCSC Perturb-seq tracks (see who regulates your favorite 3โ UTR!)
* Seurat extension for polyA site analysis (PASTA)
* Deep neural perturbation network (APARENT-Perturb)
cell.com/cell/fulltext/โฆ
6
88
314
61,667
Hornstein Lab retweeted
My team is working with a substantial arsenal of ML algorithms, analyzing diverse human molecular data. The most intriguing work imaginable. We do science and study human brain diseases, but like a small startup.
Come join us!
Come join us!
We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration.
Position details and requirements: machinelearning.co.il/job/biomedicalโฆ
CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il
#jobopportunity
0
3
9
805
We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration.
Position details and requirements: machinelearning.co.il/job/biomedicalโฆ
CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il
#jobopportunity
Position details and requirements: machinelearning.co.il/job/biomedicalโฆ
CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il
#jobopportunity
0
7
18
2,320
Hornstein Lab retweeted
Two neurons having a conversation, surrounded by some busy microglia doing their job: maintaining neuronal networks and helping with injury, repair, and pruning! The brain is beautiful! ๐ง ๐ฌ#neuroscience #Microscopy
34
298
1,678
78,206
Hornstein Lab retweeted
A confocal microscopy image of Your Majesty, the neuron, the king of the brain jungle ๐ง ๐ฌ! This one is the classical pyramidal cell, the most common neuronal type in the mammalian cerebral cortex. In blue, staining for PSD95, a major protein in excitatory synapses that helps e neurotransmitter receptors in the synaptic cleft. Each little dark blue puncta shows an excitatory synapse happening between two neurons!
Reduction or dysfunction in the PSD95 expression is related to impaired learning and working memory and is observed in diseases such as Alzheimer's and Parkinson's. Staining: ๐ SMI32๐ตPSD95 #SynapticSunday @zeiss_micro
Reduction or dysfunction in the PSD95 expression is related to impaired learning and working memory and is observed in diseases such as Alzheimer's and Parkinson's. Staining: ๐ SMI32๐ตPSD95 #SynapticSunday @zeiss_micro
44
247
1,609
135,656
Hornstein Lab retweeted
Our preprint of ๐ต๐ถ๐ฝ๐จ is out!
A deep representation learning of 24 organelles in 1.5M ๐ฌ images of human iPSC-dervied cortical neurons. We tested stress, #ALS genetic perturbations, and more.
What a fascinating road it was with this one.. ๐ข๐ง ๐งช๐งซ
A deep representation learning of 24 organelles in 1.5M ๐ฌ images of human iPSC-dervied cortical neurons. We tested stress, #ALS genetic perturbations, and more.
What a fascinating road it was with this one.. ๐ข๐ง ๐งช๐งซ
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐ก๐ข๐ฉ๐ (๐กeuronal ๐ขrganellomics ๐ฉision ๐tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology
biorxiv.org/content/10.110โฆ
0
4
22
1,704
Hornstein Lab retweeted
A new bioRxive from our lab showing a new concept: #Organellomics in #Neurons that distinguishes between cell states and conditions. A huge imaging data set of neurons and an edvanced computational work come together! It was my pleasure to be part of this fantastic work!
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐ก๐ข๐ฉ๐ (๐กeuronal ๐ขrganellomics ๐ฉision ๐tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology
biorxiv.org/content/10.110โฆ
0
3
12
1,738
Hornstein Lab retweeted
Check out our latest preprint about AI-driven ๐ค deep organellar phenotyping of human ๐ง neurons.
biorxiv.org/content/10.110โฆ
biorxiv.org/content/10.110โฆ
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐ก๐ข๐ฉ๐ (๐กeuronal ๐ขrganellomics ๐ฉision ๐tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology
biorxiv.org/content/10.110โฆ
1
2
13
662