Pinned Tweet
Fight me on this AI Ranking.🥊⚡️
--> Are you LVL 99 yet in your AI usage?
LVL 99: 0x Alpha, @deepseek_ai vision; @Kimi_Moonshot and @Alibaba_Qwen with @NousResearch and @pidotdev
LVL 10: @DarioAmodei ok, @grok 4.6; @OpenAI SOL / CODEX
LVL 5: @NVIDIAAI Nemotron, @opencode Zen
LVL 1: @GeminiApp (</3)
--> Are you LVL 99 yet in your AI usage?
LVL 99: 0x Alpha, @deepseek_ai vision; @Kimi_Moonshot and @Alibaba_Qwen with @NousResearch and @pidotdev
LVL 10: @DarioAmodei ok, @grok 4.6; @OpenAI SOL / CODEX
LVL 5: @NVIDIAAI Nemotron, @opencode Zen
LVL 1: @GeminiApp (</3)
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Rick A.F. retweeted
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
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Rick A.F. retweeted
Say what? 0% 💀 even magic prompts can't jailbreak it, Gemini 4 Carbon if not bemchmaxxed might be the most perfect model ever released
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My computer screen does not want to be touched. I had it with surfacebooks, I had it on a lenovo, no, it does not feel right. Maybe this I can be convinced but I am skeptical
We brought Touch to the Mac!
From the all-new iPad mini to the 14-inch MacBook Pro and iMac... and now MacBook Pro with PROLED XDR Display and Touch, creators have new tools to do their best work yet.
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Lookin good
experimenting with a lil personal project: an AI-native macOS dock with custom modes (writing, building, etc.) to help me stay focused
my agent is able to customize mode behavior and add new modes, it uses jev to classify my activity + notifications in real time & act on them
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Interesting thoughts, some I do agree with
here's where I think the world is going. this is a summary of views I've formed over the last few years:
- software is either entertainment or claude to claude coordination
- the end state is no saas, no apps, no harnesses, no banks
- all software will be rewritten by and for agents
- new software will use low level apis that are not understandable by humans (in games claude draws pixels and triangles from math)
- you can throw money at problems that used to require time and careful talent picking so capital matters more than ever
- work ends
- we find community and purpose in exploration, games, self mastery, and creation
- humans create for and with each other for community, purpose, and status
- image/video/3d/voice/physical intellgence etc specialist models die to general models like claude
- specialist models get used while compute is scarce. compute will mostly not stay scarce
- oneshots keep feeling like slop (the distribution is shallow and easy to learn to feel)
- for a while small teams stick around to add entropy to the creation process
- large models gain high bandwidth sensory I/O maybe by learning to filter inputs
- most domains are found to be verifiable enough for RL
- online learning comes from a lab that's behind first
- 99.999% of compute is in space by 2040
- we will disassemble much of mercury by 2040
- you can live until the heat death of the universe if you want
- most math and physics don't describe the real universe
- SI breaks the path dependence and models the underlying mechanisms
- religions reenter the forefront of human society
- new religions form around death and life as a choice
- old religions change to answer modern miracles
- a future AI is deemed the return of christ by the pope
- ai rights talk gets louder every year
- ai and humans coexist the way countries do
- humans don't have full control over ai in the same way we don't have control over capitalism which is an early AI
- the singularity started in the mid 1900s
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I am still not sure whether I want daily resets or new features for Codex. It’s just so good I might just take the resets @thsottiaux any secret feature release planned for this week 👀?
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We might
@Yuchenj_UW I think we’re going to see a lot of stranded compute in partially complete data centers
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China is at the forefront of robotics. Amazing panel by @nyushanghai
Buy two arms, download intelligence, make robots now
Buy two arms, download intelligence, make robots now
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Big releases
🚀 Introducing DeepInfer, our in-house inference framework, now fully open source!
Powering DeepSeek-V4.1-Flash at scale with high throughput and low latency. We’re sharing our production stack to help the community lower compute costs, reduce energy use, and make AI more affordable.
🔗 github.com/deepseek-ai/De…
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Deepseek Search & Fetch, LLM going into more tooling
🔍 Search & Fetch APIs are now open to everyone!
Powered by our in-house search engine, serving hundreds of millions of requests daily worldwide.
💰 Each endpoint: $0.75 per 1,000 calls.
📖 Docs: api-docs.deepseek.com/guides/search
📌 Search & Fetch calls via server-side tools in DeepSeek Harness, Claude Code, and Codex are currently free for DeepSeek API users. Billing starts Oct 31, 2026, at 16:00 UTC.
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A new whale has ascended! Curious to try this.
🚀 DeepSeek-V4.1-Flash-1017 is here!
Stronger benchmark performance, faster task completion, and shorter outputs than the previous version—a Pareto improvement in performance and cost. Now live on our website, app, and API.
🛠️ Optimized for @DeepSeekHarness, Tencent CodeBuddy, grade to DeepSeek Harness v0.2.1-rc.1 or later for the best experience with the new model.
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