“A narrow class of people is profiting. What they care about is money. Not just enough to get by on [or] to become grotesquely rich with. They want the kind of money that bends others to their will. They seek power.” Man-made climate change is real! theguardian.com/membership/202…

We are facing the biggest challenge in recent history to equal access to education and knowledge. Access to AI tools is a new mechanism for discrimination. All the while these tools are trained without permission on our common good: our thoughts, creativity, data, and intellect.

Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujw_thu on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! science.org/doi/10.1126/sc…

Obituary: Jane Goodall (1934-2025) Pioneer primatologist who inspired generations of scientists

go.nature.com/4pWj5mX

Jane Goodall, world-renowned primatologist, dies aged 91 theguardian.com/science/2025/o…

We are currently witnessing the complete succumbing to blackmail of the so-called civilized world. The speed of general moral and ethical decline in the name of economic constraints and reasoning is shocking. We must be aware that scientific integrity will not escape untouched.

A good moment to remember this quote: “The world is in greater peril from those who tolerate or encourage evil than from those who actually commit it.” Albert Einstein

Proud of my doctoral student Charlotte Schilling who successfully defended her thesis today! Congratulations, ⁦@cm_schilling⁩ ! 👏🥂

Check out our latest preprint with Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: biorxiv.org/content/10.110…

Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction.
👏 Tatjana v. Rosen @Rafal_Zdanowicz @YasserElHadeg
🔗nature.com/articles/s4146…

An oral tablet vaccine for norovirus based on an adenoviral-vectored vaccine that delivers VP1 is safe in older adults and produces a notable antibody response in the mucosa that persists for 210 days, according to results from a phase 1 trial.

Learn more in @ScienceTM: scim.ag/4hcjk7L

In our study in @ScienceAdvances, we reveal how ssDNA binding activates transcription factor PafBC, triggering the DNA damage response in #Mycobacteria.
Read more: science.org/doi/10.1126/sc…
🔬 Cryo-EM structure
🧬 ssDNA-WYL domain interaction

Great work by Charlotte Schilling @cm_schilling from @EWB_Lab in collaboration with @rafal_Zdanowicz from @Glockshuber_lab!

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! nature.com/articles/s4158…

Registration is now open for EMBO Workshop on Protein quality control: From molecular mechanisms to aging and disease 18 – 23 May 2025 in Hersonissos, Greece

📜 Early bird registration deadline: 31 Jan 2025
meetings.embo.org/event/25-prote…
#EMBOproteinQualityControl

Had a wonderful time with my group and Rudi’s team from ⁦@Glockshuber_lab⁩ at our Christmas outing! 🎄 We enjoyed “Kerzenziehen,” a wonderful Swiss tradition, and had dinner afterwards. Great company and a festive way to celebrate!

Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.

First snow on campus this year! ⁦@ETH_en⁩

Looking forward to Rudi Glockshuber's Farewell Symposium! Great science and a chance to get together, say goodbye and give thanks!
📅 Friday, November 22nd
📍 ETH Zurich, Hönggerberg Campus

We look forward to seeing you there!
@Glockshuber_lab @ETH_en