Congrats to our newest PCF Young Investigator from Minnesota, the one-and-only Dr. Ali Arafa @aliarafaa. @UMNCancer @UMNews @ThePCCTC @PCF_Science
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Thank you for adding me to the editorial board!!
Thrilled to begin as Editor-in-Chief of The Prostate! Looking forward to working with an outstanding team: @EAntonarakis, @BurcuDarst, Jun Luo, @lemonrock_MD, and @ArunRaiMD.
Grateful for Sam Denmeade's exceptional leadership & mentorship over his 6-year tenure as EIC.
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Congrats Alex Tsai and John Lozada for your provocative discovery that immunotherapy sensitivity in cancer may be associated with expansion of CD4+CD8+ (double positive) and NK-like T cells that express TCRs. @UMNews @UMNCancer cell.com/cell-reports-m…
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Congrats @laurasenamd for publishing the definitive study on IDH1-altered prostate cancers. This is a distinct molecular subtype of PCa with novel therapeutic implications (vorasidenib?). @neerajaiims @VanAllenLab @nikolausschultz europeanurology.com/action/showPdf…
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Congrats @aliarafaa and @DrJustinDrake for your elegant work on plasma extracellular vesicle (EV) proteomics in Pluvicto-treated prostate cancer patients. Blood-based detection of PSMA, B7-H3, STEAP1 and Trop2 will help precision therapeutics! @UMNCancer cell.com/cell-reports-m…
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Please check out our CASCARA trial, the first study to use a quadruplet initial systemic regimen for high-volume metastatic prostate cancer. Let’s design a randomized Phase 3 trial to explore this further. @charlesryanmd @UMNCancer aacrjournals.org/clincancerres/…
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Great talk by @ZorkoNK about B7-H3-targeting TriKEs at the DAVA Oncology meeting in Bermuda. @UMNews @UMNCancer
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Congrats @PornladaL for publishing the first comprehensive analysis of HLA class-I expression in prostate cancer, and the associated genomic, transcriptomic, immunologic, and clinical consequences. This will be a landmark paper in the field. nature.com/articles/s4139…
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It was a sheer pleasure to have
@AdamSharpMedOnc here in Minnesota delivering a Cancer Center Seminar lecture about manipulation of the apoptosis pathway for prostate cancer therapeutics. Thanks @scottdehm for inviting and hosting him. Let the collaborations begin! @UMNCancer
@AdamSharpMedOnc here in Minnesota delivering a Cancer Center Seminar lecture about manipulation of the apoptosis pathway for prostate cancer therapeutics. Thanks @scottdehm for inviting and hosting him. Let the collaborations begin! @UMNCancer
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Emmanuel Antonarakis retweeted
Just came online in @TheLancet 👉Our two papers on improved OS with Enzalutamide + Talazoparib in mCRPC #ProstateCancer in all-comer & HRRm patients (Median OS and HRs👇). Weblinks to the papers👉 bit.ly/4lXkLtB and bit.ly/4nNIyOh @PCFnews @urotoday @OncoAlert
Just in👉Two @TheLancetOncol papers on patient-reported QOL results in ph3 TALAPRO-2 trial👉in all-comer & HRR deficient mCRPC #ProstateCancer pts👉Improved OS without compromising QOL👇Links: bit.ly/3DWHlSR & bit.ly/3E3SSQi @urotoday @OncoAlert @PCFnews 👇
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Largest retrospective study (N=93) of checkpoint-inhibitor efficacy in pts with dMMR mCRPC. Those with 3-4 modes of dMMR detection (protein IHC loss, gene alteration, MSI-hi, and TMB >20) have greatest survival. euoncology.europeanurology.com/action/showPdf…
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A novel west-African germline founder mutation in HOXB13 (p.X285Kext) increases risk of high-grade prostate cancer but also enhances sensitivity to hormonal therapy. Congrats to PCF-funded Mayuko Kanayama 👏 @neerajaiims @PCFnews @urotoday @EdEsplin nature.com/articles/s4139…
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Congrats @chadihcmd for this impactful study. You are a superstar ⭐️
Just in @CCR_AACR 👉Congrats @chadihcmd @umangtalking & @Huntsman_GU team👉Poor outcomes w/ SOC Rx in mHSPC #prostatecancer w/HRRm in 637 real-world US pts👇 @flatironhealth @FoundationATCG @RyonGraf 👉 need to add PARPi 👉free link: bit.ly/3TsOw9i @OncoAlert @urotoday
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Emmanuel Antonarakis retweeted
Just in @CCR_AACR 👉Congrats @chadihcmd @umangtalking & @Huntsman_GU team👉Poor outcomes w/ SOC Rx in mHSPC #prostatecancer w/HRRm in 637 real-world US pts👇 @flatironhealth @FoundationATCG @RyonGraf 👉 need to add PARPi 👉free link: bit.ly/3TsOw9i @OncoAlert @urotoday
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Congratulations @aliarafaa on developing the first prognostic blood-based PROTEOMIC biomarker for 177Lu-PSMA-617 efficacy, presented at ASCO ‘25. @UMNCancer @UMNews meetings.asco.org/abstracts-pres…
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Congratulations to Cathy Marshall on her two papers (in the same week!) exploring CH in solid tumors. This is an important and emerging field. @CathyHandy @TempusAI academic.oup.com/oncolo/article… mdpi-res.com/d_attachment/c…
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Largest study of BRCA-associated cancers (24,309) shows that somatic tumor landscape is influenced by germline HRR muts: gBRCA1-altered cancers are enriched in somatic TP53 muts; gATM-altered cancers are depleted in TP53 mut. Congrats @aliarafaa @umncancer aacrjournals.org/clincancerres/…
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Congrats to John Lozada (MD/PhD student) for deeply characterizing DLL3 expression in neuroendocrine cancers across 29 tumor sites. @carisls @UMNCancer @UMNews @mishabeltran aacrjournals.org/cancerrescommu…
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Thank you @neerajaiims for conducting such a masterful interview and for recognizing the importance of this work
🧬 Groundbreaking insights into #FOXA1 in #ProstateCancer!
Drs. @neerajaiims @huntsmancancer, @EAntonarakis and Justin Hwang, PhD @UMNCancer discuss:
🔹 FOXA1 mutations found in 15% of cases, higher in Asian (25%) & Black (20%) patients
🔹 Opposing clinical outcomes from diffsensitivity vs. resistance
🔹 Rare FOXA1 R219 mutation linked to lineage plasticity & poor prognosis
This research paves the way for personalized approaches using DNA/RNA sequencing. More validations & collaborations ahead!
#WatchNow on UroToday > bit.ly/40GMYwN
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Congratulations @CathyHandy and thanks to @mrinalpatnaik for mentoring us
Radiotherapeutics, clonal hematopoiesis, and risk of hematologic malignancies... sciencedirect.com/science/articl… @CathyHandy @EAntonarakis #Lutetium #Actinium #CH #PPM1D #TP53 @MayoCancerCare @JohnsHopkins @UMNews
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