New paper out in @ScienceAdvances
TOP2B activity is locally inhibited during the estrogen response to favour the accumulation of DNA supercoiling and regulatory chromatin contacts that trigger transcriptional induction
science.org/doi/10.1126/sc…
TOP2B activity is locally inhibited during the estrogen response to favour the accumulation of DNA supercoiling and regulatory chromatin contacts that trigger transcriptional induction
science.org/doi/10.1126/sc…
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It's been a long journey ...
Huge congratulations to everybody involved @CNIOStopCancer @cabimer, specially the leaders of all this @JoseT86910859 @GMillanZambrano
And thanks to collaborators @AguileraLab RS Williams Lab and Mario García Domínguez
Huge congratulations to everybody involved @CNIOStopCancer @cabimer, specially the leaders of all this @JoseT86910859 @GMillanZambrano
And thanks to collaborators @AguileraLab RS Williams Lab and Mario García Domínguez
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📢Please spread the word📢
Several postdoc positions (wet and computational) open in the lab to work on different research lines (see thread)
We seek highly motivated candidates to join our team @CNIOStopCancer
cnio.es/en/research-in…
E-mail CV and brief motivation statement
Several postdoc positions (wet and computational) open in the lab to work on different research lines (see thread)
We seek highly motivated candidates to join our team @CNIOStopCancer
cnio.es/en/research-in…
E-mail CV and brief motivation statement
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2. DSB repair and genome instability mechanisms. Following on our recent REPAIRome study
science.org/doi/10.1126/sc…
Funding: @AgEInves
science.org/doi/10.1126/sc…
Funding: @AgEInves
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- Topoisomerase-induced DNA breaks in cancer chemotherapy. Building on the traditional research line of the lab
nature.com/articles/natur…
science.org/doi/10.1126/sc…
Funding: @CaixaResearch and @ContraCancerEs
nature.com/articles/natur…
science.org/doi/10.1126/sc…
Funding: @CaixaResearch and @ContraCancerEs
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Congratulations to all the people involved, also in @ChromDyn @rfleiro @gjmacintyre labs @CNIOStopCancer
Specially leading authors @ErnestoLDA1811 Israel Salguero and @DanielGLL_
Very proud of you!!!
Specially leading authors @ErnestoLDA1811 Israel Salguero and @DanielGLL_
Very proud of you!!!
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Check out our web tool to see interactive networks of DSB repair genes, browse your gene of interest for its contribution to DSB repair profiles and analyze functional relationships based on similarities in repair patterns
repairome.bioinfo.cnio.es
Enjoy!!!
repairome.bioinfo.cnio.es
Enjoy!!!
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Cortés Lab retweeted
Researches at #cniostopcancer create the ‘human repairome’, a catalogue of DNA ‘scars’ that will help define personalised cancer treatments.
Published in @ScienceMagazine
bit.ly/4fGk4CV
Published in @ScienceMagazine
bit.ly/4fGk4CV
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Cortés Lab retweeted
@ScienceMagazine 🧬The human repairome, REPAIRome, will allow researchers around the world to check out how each of the 20,000 human genes affects DNA repair.
Authors: @CortesLab @ErnestoLDA1811 Israel Salguero Daniel Giménez et al.
Funding: @CienciaGob @AgEInves @Europarl_ES
Authors: @CortesLab @ErnestoLDA1811 Israel Salguero Daniel Giménez et al.
Funding: @CienciaGob @AgEInves @Europarl_ES
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Cortés Lab retweeted
@ScienceMagazine @CortesLab @ErnestoLDA1811 @CienciaGob @AgEInves @Europarl_ES The repairome is ‘a platform for new discoveries', which has already helped to detect new genetic mechanisms involved in kidney cancer, and will allows progress ‘towards full control of CRISPR-Cas gene-editing technologies’.
Infographic: @CireniaSketches
bit.ly/4fGk4CV
Infographic: @CireniaSketches
bit.ly/4fGk4CV
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Cortés Lab retweeted
Have a look at our review in @MolecularCell . We explore how histone modifications serve as integrators of genome activity, mediating communication between distinct DNA procesess. authors.elsevier.com/a/1kS2f3vVUPRn…
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Cortés Lab retweeted
En nuestro grupo en @cabimer investigamos sobre el síndrome por deficiencia en el gen CHD8. Buscamos a personas diagnosticadas con alteraciones en este gen, para asociarnos, intercambiar experiencias y aumentar el conocimiento sobre el síndrome.👇👇
Yeray ha sido diagnosticado de síndrome #CHD8, una enfermedad que solo sufren 167 personas en el mundo, 4 ellos en España.
“Quiero dar visibilidad a esta enfermedad para ayudar a mi hijo", explica su madre.
laopiniondezamora.es/castilla-leon/…
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Cortés Lab retweeted
Many thanks to @FundlaCaixa @CaixaResearch for the incredible support to work on this important problem together with Borja Ibarra @3M_Lab and Cristina Ugalde
Postdoc positions will be opening soon!
Exciting times ahead!
Postdoc positions will be opening soon!
Exciting times ahead!
🧬Errores en la replicación del ADN de las mitocondrias —un componente celular— se asocian a trastornos neurodegenerativos como el alzhéimer y el párkinson.
Con una ayuda #CaixaResearch, @rfleiro investigará cómo contribuyen estos errores a las patologías, lo que permitirá ximaciones terapéuticas.
tinyurl.com/5n7etfrr
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Cortés Lab retweeted
Cuatro investigadores del #CNIOStopCancer reciben financiación @CaixaResearch.
cnio.es/noticias/cuatr…
cnio.es/noticias/cuatr…
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Very excited with the opportunity to take our basic discoveries on DNA topology and topoisomerase function to possible applications in our fight against cancer with this #CaixaResearch grant
Thanks @CaixaResearch!
Opportunities to join this project @CNIOStopCancer will follow
Thanks @CaixaResearch!
Opportunities to join this project @CNIOStopCancer will follow
🧬 Debido a su rápido crecimiento, las células tumorales son más propensas a acumular nudos y enredos en su ADN.
Con una ayuda #CaixaResearch, @CortesLab estudiará cómo pueden estos errores usarse para desarrollar nuevas herramientas de diagnóstico y tratamiento del cáncer.💊
O
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Cortés Lab retweeted
@FundlaCaixa @FundlaCaixaPT @carvalho_ago @CoralBarbasAr @ManelEsteller @VHIR_ @icn2nano @UniBarcelona @CIBERBBN @pmaciel_icvs @piacosma @Pasquali_Lab @LickertHeiko @Gsabiolab @MariaJ_Alonso @GimenezMarques @VidalPuig @mromerogomez 16/ 🏆Llegamos al ecuador de la ceremonia con los 6 reconocimientos en oncología, entregados por:
🔵 Juan Ramón Fuertes, director general adjunto @FundlaCaixa
🔵 Ignasi López, director del Área de Relaciones con Instituciones de Investigación y
Salud @FundlaCaixa
🔵 Juan Ramón Fuertes, director general adjunto @FundlaCaixa
🔵 Ignasi López, director del Área de Relaciones con Instituciones de Investigación y
Salud @FundlaCaixa
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