🚨 New from our lab (est. 2020) — now published in Nature Communications!
🧬We uncover a surprising link between the v-ATPaseand mitochondrial function:
Mild v-ATPase inhibition restores cell fitness under mitochondrial mistranslation stress
nature.com/articles/s4146…
(Thread ⬇️)

Mild v-ATPase inhibition boosts ΔΨm and restores cell fitness under mitochondrial mistranslation stress — even in patient-derived fibroblasts.
🔬A major effort led by Geoffray, revealing how cells deploy extra-organellar control to survive mitochondrial dysfunction.

🔥This opens a path toward targeting v-ATPase with precision, with implications from cancer to mitochondrial disease.

Together with @mito_oncogene, today we report in Nature Genetics a peculiar + exciting discovery: positive selection of mutations to mitochondrial ribosomal RNA in cancer. Led by Sonia Boscenco, Jacqueline Tait-Mulder, and Minsoo Kim nature.com/articles/s4158…

Local de novo synthesis of serine delays mitochondrial muscle disease progression. Tour de force work of Christopher Jackson and ⁦@marmyleva_ana⁩ Anastasiia Marmyleva. Congrats Anastasiia especially for your first 1st author paper! ⁦@ASW_lab⁩ cell.com/cell-reports/f…

✨Excited to share our new paper in @CellReports! ✨We show how cells rely on self-made serine to protect themselves under mitochondrial stress. Huge thanks to my mentors @CBJacksonLab and @AWartiovaara 🙏

cell.com/cell-reports/f…

Unique architectural features of mammalian mitochondrial protein synthesis
30-day free access to our new review at: authors.elsevier.com/a/1jE3u3QxxSux…
Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.

Please check out out our paper with @CBJacksonLab and @Solocanuck👇
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation cell.com/iscience/fullt…
@GMonteuuis @KrysiaBroda @ElizabethPyman @_DiegoBalboa_ 1/7

In the latest issue! Problem choice and decision trees in science and engineering dlvr.it/T5V7S5

Our mapping of the cellular protein #interactome with unprecedented depth is now published @Nature. Leaps in robust #proteomics and analytic workflows enabled us to perform over 4.000 pull-downs in yeast unraveling the social and structural aspects leveraging #alphafold multimer.

Welcome to the Metabolism seminar on Friday, Oct 13th at 9-11 am, Haartman Institute Lecture Hall 2. Talks on nutrient transporters in cancer and mitochondrial quality control by @Rafabolism and @CBJacksonLab ☕️🍪at 8:30. Spread the word @STEMMProgram @HelsinkiUniMed @BIOTECH_UH

World Mitochondrial Disease Week mitochondrialdiseaseweek.org

“… it is estimated, 50m tonnes of her cells have been produced.”

in other words: 700 Million people worth of cells.

Our preprint show that knock-in mice with drastically reduced levels respirasomes have normal OXPHOS function and no obvious phenotypes! Very unexpected results indeed! Presented the story at EuroMit. Thanks all coauthors for a very nice collaboration!
biorxiv.org/content/10.110…

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase s) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec.

We explore 4 intracellular and intercellular applications of TransitID:
- discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix)
- mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress
- discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery
- analysis of proteins that traffic intercellularly bw tumor cells & macrophages

Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor

authors.elsevier.com/a/1hKLcL7PXmcqA

Interested in a postdoctoral project encompassing genome-wide CRISPR/Cas9 screening and mitochondrial metabolism? Let’s apply for a Marie Sklodowska-Curie Postdoctoral Fellowship. Deadline: 13.09.2023 #msca #postdoc #fellowship #funding

PhD position available in our group: project in genome-wide signalling and cell-type-specific susceptibility to mitochondrial translation defects. Please RT and get in touch jacksonlab.org @mitojobs

This position is now filled.

We love what this image @Euromit2023 represents. Knowledge, passion, strength, community & commitment to #mitochondrialdisease patients across the globe. 821 professionals from 38 countries attended the conference. Together we are strong & together we are making a difference.