Pinned Tweet
My top ten tips for graduating fellows and faculty entering and continuing “early career” as I am transitioning into “mid-career”. A thread:
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Andrew J Sauer MD retweeted
Congratulations to the 2026 HFC Site-Based Research Award recipients! 🏆
We celebrate the outstanding principal investigators advancing cardiovascular research.
Meet the awardees being recognized at #AHA26 hfcollaboratory.com/awards/
We celebrate the outstanding principal investigators advancing cardiovascular research.
Meet the awardees being recognized at #AHA26 hfcollaboratory.com/awards/
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Andrew J Sauer MD retweeted
@docwarsi Misperception of risk, lack of urgency, outdated algorithms, inertia, and misaligned incentive are major drivers
Many system based solutions exist, yet are not implemented at scale
Changes in policies could potentially incentivize improvements
Many system based solutions exist, yet are not implemented at scale
Changes in policies could potentially incentivize improvements
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Andrew J Sauer MD retweeted
@docwarsi @ATSandhu @paheidenreich @texhern @DCRINews @AndrewJSauer @NMHheartdoc @MKIttlesonMD @rkwadhera @SJGreene_md @BiykemB Terrific
Incentivize practices for getting HFrEF patients on all four pillars, and set a target that rewards progress over perfection
That's how a policy can turn the HF guideline into care
If only @CMSGov weren't twenty years behind in HF measures
Incentivize practices for getting HFrEF patients on all four pillars, and set a target that rewards progress over perfection
That's how a policy can turn the HF guideline into care
If only @CMSGov weren't twenty years behind in HF measures
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Andrew J Sauer MD retweeted
National Impact of Optimal Implementation of Guideline-Directed Medical Therapy in Heart Failure With Reduced Ejection Fraction
Incomplete implementation of quadruple GDMT in HFrEF remains a major modifiable opportunity to reduce preventable deaths and HF hospitalizations in the rnals @ACCinTouch @DrMarthaGulati @SJGreene_md @gcfmd @HFA_President @AndrewJSauer @dranulala
jacc.org/doi/10.1016/j.…
Incomplete implementation of quadruple GDMT in HFrEF remains a major modifiable opportunity to reduce preventable deaths and HF hospitalizations in the rnals @ACCinTouch @DrMarthaGulati @SJGreene_md @gcfmd @HFA_President @AndrewJSauer @dranulala
jacc.org/doi/10.1016/j.…
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Andrew J Sauer MD retweeted
Heading to AHA Scientific Sessions 2026 in Chicago?
I’d love to connect with colleagues interested in what’s next for finerenone in heart failure on Friday evening.
I’m extending an open invitation to investigators, clinicians, and research teams to join us at the University n how the MOONRAKER program is moving forward—and explore opportunities to contribute to this work.
Building on FINEARTS-HF, three complementary phase 3 trials are addressing questions that matter in everyday clinical practice:
• REDEFINE-HF: Evaluating whether finerenone reduces cardiovascular death and first and recurrent HF events in patients hospitalized with acute heart failure and LVEF ≥40%. This will extend the evidence into the vulnerable period surrounding an HF hospitalization.
• CONFIRMATION-HF: Testing an early treatment strategy combining finerenone with an SGLT2 inhibitor across the EF spectrum, assessing whether this approach improves clinical outcomes and patient-reported symptoms compared with usual care following an HF hospitalization.
• FINALITY-HF: Evaluating finerenone in patients with HFrEF who are intolerant of or ineligible for steroidal MRAs, generating evidence on cardiovascular death, HF events, symptoms, and safety in a population with an important unmet treatment need.
Together, these studies will clarify where finerenone fits across HF populations and care settings, including its role in early combination therapy and in patients with limited treatment options.
I’m proud of our Saint Luke's Mid America Heart Institute team’s collaboration with Marc Bonaca, CPC Clinical Research, and investigators worldwide to advance this program.
Whether you’re already involved in MOONRAKER, interested in research collaboration, or simply want to learn more, please join us for an evening of conversation and connection.
📍 University Club of Chicago
76 East Monroe Street, Chicago
Message me for reception details and RSVP. I look forward to seeing you in Chicago!
I’d love to connect with colleagues interested in what’s next for finerenone in heart failure on Friday evening.
I’m extending an open invitation to investigators, clinicians, and research teams to join us at the University n how the MOONRAKER program is moving forward—and explore opportunities to contribute to this work.
Building on FINEARTS-HF, three complementary phase 3 trials are addressing questions that matter in everyday clinical practice:
• REDEFINE-HF: Evaluating whether finerenone reduces cardiovascular death and first and recurrent HF events in patients hospitalized with acute heart failure and LVEF ≥40%. This will extend the evidence into the vulnerable period surrounding an HF hospitalization.
• CONFIRMATION-HF: Testing an early treatment strategy combining finerenone with an SGLT2 inhibitor across the EF spectrum, assessing whether this approach improves clinical outcomes and patient-reported symptoms compared with usual care following an HF hospitalization.
• FINALITY-HF: Evaluating finerenone in patients with HFrEF who are intolerant of or ineligible for steroidal MRAs, generating evidence on cardiovascular death, HF events, symptoms, and safety in a population with an important unmet treatment need.
Together, these studies will clarify where finerenone fits across HF populations and care settings, including its role in early combination therapy and in patients with limited treatment options.
I’m proud of our Saint Luke's Mid America Heart Institute team’s collaboration with Marc Bonaca, CPC Clinical Research, and investigators worldwide to advance this program.
Whether you’re already involved in MOONRAKER, interested in research collaboration, or simply want to learn more, please join us for an evening of conversation and connection.
📍 University Club of Chicago
76 East Monroe Street, Chicago
Message me for reception details and RSVP. I look forward to seeing you in Chicago!
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Andrew J Sauer MD retweeted
Multiple roommates. Ramen noodles. Near public transportation. Respect to the people who do whatever it takes.
I worked as a bartender. Bar-back. $2.15 an hr plus whatever tips got shared. Worked at a retail store. Never had benefits at any job.
Had 5 roommates in a 3 br apt. Ate lousy food out of cans and ate a ton of peanuts and shit food at happy hour. Had credit cards ripped up. Etc.
But I learned a ton. Taught me what was right and wrong about running a business by watching my bosses and their bosses
Yeah I know. It was much easier then, when inflation was 15 pct and national unemployment was 10 %. I know I was fortunate when I finally got fired from the store, and had to start my own business with zero cash. Bill collectors everywhere.
Even luckier when I found my first customer so I could pay my bills
But I recognize it’s so much harder today.
Which is why I respect the people who are willing to do what it takes to get started
I worked as a bartender. Bar-back. $2.15 an hr plus whatever tips got shared. Worked at a retail store. Never had benefits at any job.
Had 5 roommates in a 3 br apt. Ate lousy food out of cans and ate a ton of peanuts and shit food at happy hour. Had credit cards ripped up. Etc.
But I learned a ton. Taught me what was right and wrong about running a business by watching my bosses and their bosses
Yeah I know. It was much easier then, when inflation was 15 pct and national unemployment was 10 %. I know I was fortunate when I finally got fired from the store, and had to start my own business with zero cash. Bill collectors everywhere.
Even luckier when I found my first customer so I could pay my bills
But I recognize it’s so much harder today.
Which is why I respect the people who are willing to do what it takes to get started
@BarefootStudent Would love @mcuban to explain how someone at McDonalds can afford rent (and other living expenses)
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Heading to AHA Scientific Sessions 2026 in Chicago?
I’d love to connect with colleagues interested in what’s next for finerenone in heart failure on Friday evening.
I’m extending an open invitation to investigators, clinicians, and research teams to join us at the University n how the MOONRAKER program is moving forward—and explore opportunities to contribute to this work.
Building on FINEARTS-HF, three complementary phase 3 trials are addressing questions that matter in everyday clinical practice:
• REDEFINE-HF: Evaluating whether finerenone reduces cardiovascular death and first and recurrent HF events in patients hospitalized with acute heart failure and LVEF ≥40%. This will extend the evidence into the vulnerable period surrounding an HF hospitalization.
• CONFIRMATION-HF: Testing an early treatment strategy combining finerenone with an SGLT2 inhibitor across the EF spectrum, assessing whether this approach improves clinical outcomes and patient-reported symptoms compared with usual care following an HF hospitalization.
• FINALITY-HF: Evaluating finerenone in patients with HFrEF who are intolerant of or ineligible for steroidal MRAs, generating evidence on cardiovascular death, HF events, symptoms, and safety in a population with an important unmet treatment need.
Together, these studies will clarify where finerenone fits across HF populations and care settings, including its role in early combination therapy and in patients with limited treatment options.
I’m proud of our Saint Luke's Mid America Heart Institute team’s collaboration with Marc Bonaca, CPC Clinical Research, and investigators worldwide to advance this program.
Whether you’re already involved in MOONRAKER, interested in research collaboration, or simply want to learn more, please join us for an evening of conversation and connection.
📍 University Club of Chicago
76 East Monroe Street, Chicago
Message me for reception details and RSVP. I look forward to seeing you in Chicago!
I’d love to connect with colleagues interested in what’s next for finerenone in heart failure on Friday evening.
I’m extending an open invitation to investigators, clinicians, and research teams to join us at the University n how the MOONRAKER program is moving forward—and explore opportunities to contribute to this work.
Building on FINEARTS-HF, three complementary phase 3 trials are addressing questions that matter in everyday clinical practice:
• REDEFINE-HF: Evaluating whether finerenone reduces cardiovascular death and first and recurrent HF events in patients hospitalized with acute heart failure and LVEF ≥40%. This will extend the evidence into the vulnerable period surrounding an HF hospitalization.
• CONFIRMATION-HF: Testing an early treatment strategy combining finerenone with an SGLT2 inhibitor across the EF spectrum, assessing whether this approach improves clinical outcomes and patient-reported symptoms compared with usual care following an HF hospitalization.
• FINALITY-HF: Evaluating finerenone in patients with HFrEF who are intolerant of or ineligible for steroidal MRAs, generating evidence on cardiovascular death, HF events, symptoms, and safety in a population with an important unmet treatment need.
Together, these studies will clarify where finerenone fits across HF populations and care settings, including its role in early combination therapy and in patients with limited treatment options.
I’m proud of our Saint Luke's Mid America Heart Institute team’s collaboration with Marc Bonaca, CPC Clinical Research, and investigators worldwide to advance this program.
Whether you’re already involved in MOONRAKER, interested in research collaboration, or simply want to learn more, please join us for an evening of conversation and connection.
📍 University Club of Chicago
76 East Monroe Street, Chicago
Message me for reception details and RSVP. I look forward to seeing you in Chicago!
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Andrew J Sauer MD retweeted
Non-Invasive Stimulation of the Median Nerve: Neuromodulation to Reduce Atrial Arrhythmias in Paroxysmal Atrial Fibrillation (The Randomized BEAT-AF Pilot Study)
heartrhythmjournal.com/article/S1547-…
heartrhythmjournal.com/article/S1547-…
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Andrew J Sauer MD retweeted
Thank you, #HFSA2026! 💙
From groundbreaking science to unforgettable connections, this year's Annual Scientific Meeting brought the heart failure community together in a big way. Thank you to everyone who joined us in Phoenix, presented research, asked questions, and showed up forward.
We can't wait to do it all again next year In Charlotte, NC!
From groundbreaking science to unforgettable connections, this year's Annual Scientific Meeting brought the heart failure community together in a big way. Thank you to everyone who joined us in Phoenix, presented research, asked questions, and showed up forward.
We can't wait to do it all again next year In Charlotte, NC!
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Andrew J Sauer MD retweeted
1/. New publication alert! 🚨
Our lab’s multi-year collaborative work with the labs of @gsducker and @RutterLab just published in @Nature. Our work led to the discovery of a new pathway through which the heart can use lactate to generate energy.
nature.com/articles/s4158…
Our lab’s multi-year collaborative work with the labs of @gsducker and @RutterLab just published in @Nature. Our work led to the discovery of a new pathway through which the heart can use lactate to generate energy.
nature.com/articles/s4158…
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Andrew J Sauer MD retweeted
Out now in @ESC_Journals from #HFC member @JavedButler1 et al.
This study evaluates the prognostic significance of residual moderate secondary mitral regurgitation in patients with heart failure after optimization of guideline-directed medical therapy. doi.org/10.1093/eschf/…
This study evaluates the prognostic significance of residual moderate secondary mitral regurgitation in patients with heart failure after optimization of guideline-directed medical therapy. doi.org/10.1093/eschf/…
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Everyone has to start somewhere.
Take a risk. Put yourself out there.
And it’s great to give people a chance.
Take a risk. Put yourself out there.
And it’s great to give people a chance.
Before Hollywood, I was living in a van in Hawaii and waiting tables at Bubba Gump Shrimp Company. One day, the incredible Rae Dawn Chong walked into the restaurant, and naturally, I went up to her table and said, “Hey, you’re a movie star! What are you doing here?”
She asked if , “Fuck yeah, put me in your movie!”
She asked for my phone number. The only problem was I didn’t have one. So I gave her my buddy Mike’s number instead. A couple days later, Mike casually mentions, “Oh, by the way, someone called you.” ARE YOU KIDDING ME, MIKE?!
I called her back, and sure enough, she was serious. I drove over to pick up the script, went back to Mike’s house, and read all 120 pages three times in a row. First script I’d ever read. My character's name was Devon, and I remember thinking, “Sweet! I could totally play a Devon!”
I showed up to the audition with every line and inflection mapped out in pencil. Rae told me I could act and offered me the part. I asked if we were shooting in Hawaii. Nope. Los Angeles.
I had about $60 to my name, a bag of clothes, and some rollerblades.
Then Rae told me they'd fly me out. And I remember thinking right then and there, my life just changed forever. I'm going to be an actor.
That little movie was Cursed Part 3, a low-budget horror comedy that opened the door to Hollywood for me.
I'll forever be grateful to Rae for taking a chance on a kid working at a shrimp restaurant. Everybody starts somewhere, and this is where it all began for me.
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Andrew J Sauer MD retweeted
Before Hollywood, I was living in a van in Hawaii and waiting tables at Bubba Gump Shrimp Company. One day, the incredible Rae Dawn Chong walked into the restaurant, and naturally, I went up to her table and said, “Hey, you’re a movie star! What are you doing here?”
She asked if , “Fuck yeah, put me in your movie!”
She asked for my phone number. The only problem was I didn’t have one. So I gave her my buddy Mike’s number instead. A couple days later, Mike casually mentions, “Oh, by the way, someone called you.” ARE YOU KIDDING ME, MIKE?!
I called her back, and sure enough, she was serious. I drove over to pick up the script, went back to Mike’s house, and read all 120 pages three times in a row. First script I’d ever read. My character's name was Devon, and I remember thinking, “Sweet! I could totally play a Devon!”
I showed up to the audition with every line and inflection mapped out in pencil. Rae told me I could act and offered me the part. I asked if we were shooting in Hawaii. Nope. Los Angeles.
I had about $60 to my name, a bag of clothes, and some rollerblades.
Then Rae told me they'd fly me out. And I remember thinking right then and there, my life just changed forever. I'm going to be an actor.
That little movie was Cursed Part 3, a low-budget horror comedy that opened the door to Hollywood for me.
I'll forever be grateful to Rae for taking a chance on a kid working at a shrimp restaurant. Everybody starts somewhere, and this is where it all began for me.
She asked if , “Fuck yeah, put me in your movie!”
She asked for my phone number. The only problem was I didn’t have one. So I gave her my buddy Mike’s number instead. A couple days later, Mike casually mentions, “Oh, by the way, someone called you.” ARE YOU KIDDING ME, MIKE?!
I called her back, and sure enough, she was serious. I drove over to pick up the script, went back to Mike’s house, and read all 120 pages three times in a row. First script I’d ever read. My character's name was Devon, and I remember thinking, “Sweet! I could totally play a Devon!”
I showed up to the audition with every line and inflection mapped out in pencil. Rae told me I could act and offered me the part. I asked if we were shooting in Hawaii. Nope. Los Angeles.
I had about $60 to my name, a bag of clothes, and some rollerblades.
Then Rae told me they'd fly me out. And I remember thinking right then and there, my life just changed forever. I'm going to be an actor.
That little movie was Cursed Part 3, a low-budget horror comedy that opened the door to Hollywood for me.
I'll forever be grateful to Rae for taking a chance on a kid working at a shrimp restaurant. Everybody starts somewhere, and this is where it all began for me.
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Andrew J Sauer MD retweeted
LBB Area Pacing vs RV Pacing for AV Block and Preserved Left Ventricular Function:
The #LEAP-Block Trial
📍499 patients with #LVEF ≥50% randomized to LBBAP vs #RVP across 14 Chinese hospitals.
📍 Primary endpoint: 2.4% vs 12.5% favoring #LBBAP (P=0.003).
📍 HF events: 3.4% vs .
📍 LBBAP ⬇️ the 24-month primary endpoint risk (HR 0.37, 95% CI 0.19–0.73), with no significant differences in mortality or device complications.
#LEAPBlock #Cardiology #HeartFailure #Pacing
jamanetwork.com/journals/jama/…
@JAMACardio #JAMA
The #LEAP-Block Trial
📍499 patients with #LVEF ≥50% randomized to LBBAP vs #RVP across 14 Chinese hospitals.
📍 Primary endpoint: 2.4% vs 12.5% favoring #LBBAP (P=0.003).
📍 HF events: 3.4% vs .
📍 LBBAP ⬇️ the 24-month primary endpoint risk (HR 0.37, 95% CI 0.19–0.73), with no significant differences in mortality or device complications.
#LEAPBlock #Cardiology #HeartFailure #Pacing
jamanetwork.com/journals/jama/…
@JAMACardio #JAMA
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Andrew J Sauer MD retweeted
Right heart failure isn’t a footnote to left heart disease. RHF is its own clinical syndrome, with its own physiology, risks, and treatment approach. HFSA’s new Scientific Statement makes the case for treating it that way. @JCardFail @RyanJTedfordMD @UChicagoCardio 5q
🔗 Additional resources: hfsa.org/right-heart-fa…
🔗 Additional resources: hfsa.org/right-heart-fa…
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Andrew J Sauer MD retweeted
🆕 in OpenSource: Cardiology
Can septal myectomy for obstructive HCM be done safely and effectively outside a high-volume center?
97% of high-volume centers are in large metropolitan areas. At LVHN, one surgeon performed 146 septal myectomies from 2006 to 2023 for patients iles away. Outcomes compared favorably with national series.
The authors’ takeaway: at lower-volume centers, concentrating septal myectomy in a single operator may help build and keep expertise, and bring HCM surgery closer to home.
opensourcecardiology.org/doi/osc.2026.0…
Free to read, no paywalls
@lvhnsm
Can septal myectomy for obstructive HCM be done safely and effectively outside a high-volume center?
97% of high-volume centers are in large metropolitan areas. At LVHN, one surgeon performed 146 septal myectomies from 2006 to 2023 for patients iles away. Outcomes compared favorably with national series.
The authors’ takeaway: at lower-volume centers, concentrating septal myectomy in a single operator may help build and keep expertise, and bring HCM surgery closer to home.
opensourcecardiology.org/doi/osc.2026.0…
Free to read, no paywalls
@lvhnsm
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Andrew J Sauer MD retweeted
Are you attending #AHA2026 in Chicago? Please join us for our annual #WIC Luncheon. We will honor our 2026 WIC Mentoring Award recipient, Dr. Svati Shah. This will be followed by a lively panel discussion. The topic this year is:
“The Mentorship Tree: Generations of Paying It @SvatiShah @Bweber04 @MonSangh @Drroxmehran @manesh_patelMD @drstaceyrosen @EugeniaGianos @drtaranarula @DrMarthaGulati @iamritu @purviparwani @AnaBaracCardio @WomenAs1 @WomenHeartOrg @JonPHeart @GarimaVSharmaMD @a_l_bailey @CardioNerds @DrJenniferCo_Vu @PamelaBMorris @pamelasdouglas @SamiaMoraMD @avolgman @SharonneHayes @gina_lundberg @NMHheartdoc @RBP0612 @emilyswlau
“The Mentorship Tree: Generations of Paying It @SvatiShah @Bweber04 @MonSangh @Drroxmehran @manesh_patelMD @drstaceyrosen @EugeniaGianos @drtaranarula @DrMarthaGulati @iamritu @purviparwani @AnaBaracCardio @WomenAs1 @WomenHeartOrg @JonPHeart @GarimaVSharmaMD @a_l_bailey @CardioNerds @DrJenniferCo_Vu @PamelaBMorris @pamelasdouglas @SamiaMoraMD @avolgman @SharonneHayes @gina_lundberg @NMHheartdoc @RBP0612 @emilyswlau
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Andrew J Sauer MD retweeted
Following #HFSA2026, we're keeping the momentum going with JCF's October issue.
Discover new research and insights from across the field of #HeartFailure.
📖 Read now: onlinejcf.com/current
Discover new research and insights from across the field of #HeartFailure.
📖 Read now: onlinejcf.com/current
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