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I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s4158… @UofUBiochem 1/10
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Gregory Ducker retweeted
Happy to report a rigorously controlled, comprehensively characterized mouse model in which cachexia is driven specifically by lung metastases, paired with a genetically identical, non-cachectic control group. Hope cachexia researchers find it useful. biorxiv.org/content/10.648…
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Gregory Ducker retweeted
How does the heart use glucose and lactate at the same time? New research reveals how this system helps fuel the heart under stress.
See what researchers discovered: healthcare.utah.edu/newsroom/news/…
@StavrosDrakos @gsducker @EleniTseliou2 @ChaudhuriLab @RobinShawCVRTI @UofUInternalMed th @UofUResearch @RobinShawCVRTI
#HeartResearch #CVRTI
See what researchers discovered: healthcare.utah.edu/newsroom/news/…
@StavrosDrakos @gsducker @EleniTseliou2 @ChaudhuriLab @RobinShawCVRTI @UofUInternalMed th @UofUResearch @RobinShawCVRTI
#HeartResearch #CVRTI
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Gregory Ducker retweeted
Throughout his career, Jon Clardy helped shape the field of natural products. His record of discovering the most influential naturally occurring small molecules is extraordinary and unmatched. He was a humble man, and his kindness and warmth will be deeply missed
Jon Clardy: 1943-2026
One of the most impactful, creative, and (quietly) irreverent practitioners of chemical biology. Transformed how we think about nature's chemicals: their structures, their role in biology. Loved him -- he had tremendous influence on my thinking.
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Gregory Ducker retweeted
Although lactate has been studied for centuries, there is still controversy about how this molecule is handled by cells
go.nature.com/4swm9HX
go.nature.com/4swm9HX
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See our paper in Nature!
Nature research paper: MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
go.nature.com/4A46lix
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Gregory Ducker retweeted
Nature research paper: MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
go.nature.com/4A46lix
go.nature.com/4A46lix
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Gregory Ducker retweeted
Congratulations. I've been hearing about this wonderful work for a long time from Jared.
1/. New publication alert! 🚨
Our lab’s multi-year collaborative work with the labs of @gsducker and @RutterLab just published in @Nature. Our work led to the discovery of a new pathway through which the heart can use lactate to generate energy.
nature.com/articles/s4158…
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Gregory Ducker retweeted
1/. New publication alert! 🚨
Our lab’s multi-year collaborative work with the labs of @gsducker and @RutterLab just published in @Nature. Our work led to the discovery of a new pathway through which the heart can use lactate to generate energy.
nature.com/articles/s4158…
Our lab’s multi-year collaborative work with the labs of @gsducker and @RutterLab just published in @Nature. Our work led to the discovery of a new pathway through which the heart can use lactate to generate energy.
nature.com/articles/s4158…
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Gregory Ducker retweeted
In lieu of flowers, memorial contributions may be made to:
Johns Hopkins Alzheimer’s Disease Research Center Fund
alzresearch.org/giving/
Alzheimer’s Foundation of America Caregiver Resources
alzfdn.org/donate/
Photo Credit: Tommy Garcia
Johns Hopkins Alzheimer’s Disease Research Center Fund
alzresearch.org/giving/
Alzheimer’s Foundation of America Caregiver Resources
alzfdn.org/donate/
Photo Credit: Tommy Garcia
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Gregory Ducker retweeted
Our @Nature paper is out!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s4158…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s4158…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
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Gregory Ducker retweeted
Dogma-defying 😆 let’s go! I always read papers that challenged the field but never thought that I would be apart of one myself. So awesome 👏
I first presented this story at @KeystoneSymp in Breckenridge in 2022.
@zoltarany was skeptical. But he took the idea seriously.
Over the next few years, whenever we crossed paths, he kept challenging me on it. Those conversations helped me understand just how high the burden of proof would be to convince the field. The paper is better because of them.
Eventually: “You might be right.”
Four years later, @AranyLab’s Trace Thome and Zolt have written a thoughtful commentary on our paper. Apparently we’ve advanced to “dogma-defying.”
One day I might actually be right...
nature.com/articles/d4158…
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Gregory Ducker retweeted
A tremendously collaborative effort led by co-first authors: @molecularpepsi (our amazing former postdoc), @joevisker, @jn_velascosilva, and James Carrington (our awesome grad student)!
Congrats to all authors, co-senior authors @gsducker and @StavrosDrakos, and everyone who contributed!
Congrats to all authors, co-senior authors @gsducker and @StavrosDrakos, and everyone who contributed!
I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s4158… @UofUBiochem 1/10
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@UofUBiochem @molecularpepsi @joevisker @jn_velascosilva @RutterLab @StavrosDrakos @UofUHealth Big picture: the heart has two routes to oxidize carbohydrate-derived carbon. One imports pyruvate via MPC; the other lactate via MCT1. That flexibility helps sustain the heart under stress and a reminder that metabolism is context dependent and can work differently in vivo.10/10
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@UofUBiochem @molecularpepsi @joevisker @jn_velascosilva @RutterLab @StavrosDrakos @UofUHealth See this beautiful write up from Zoltan Arany and colleagues which places our findings in context. nature.com/articles/d4158…
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Gregory Ducker retweeted
Folks, despite my best efforts, I regret to announce that I have published a paper in @Nature.
I can finally become one of those annoying PIs who tells trainees they don’t need a Nature paper to get a faculty job.
#blessed @mbeisen
nature.com/articles/s4158…
I can finally become one of those annoying PIs who tells trainees they don’t need a Nature paper to get a faculty job.
#blessed @mbeisen
nature.com/articles/s4158…
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