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Our newest work from @BizarMd lab is now in print at @CellCellPress! Check out our tweetorial below to learn more about our work establishing a scalable variant classification appraoch for inborn errors of immunity, which has already directly enabled the treatment of a patient!
In the latest issue! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment dlvr.it/TMw5BV
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Incredible experience to present our newest work for a packed auditorium at #ASGCT2026 yesterday. This has been a dream project to cap off my time in the lab, alongside my dear friend and brilliant co-lead @FrangiehChris and our fearless leader @BizarMd. More to come soon!
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Absolutely surreal to have been named as one of the 2026 recipients of the Weintraub Award! An incredible honor, and one that would not have been possible without @BizarMd and the incredible lab and community he has created @ColumbiaMed @columbiacancer @Columbia
Huge congratulations to the recipients of the 2026 Weintraub Award! These twelve exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. fredhutch.org/en/news/releas…
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It was an incredible honor to be hosted at @StanfordMed for the @StanfordPath annual retreat as the inaugural recipient of the national Galli Prize in Pathology! Endless thanks to @BizarMd for his mentorship and to the whole Izar lab family
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Zach Walsh retweeted
Great preview from @SanchoShimizu on the challenge of VUS in inborn errors of immunity and in general.
AND on the fact that IEIs are likely more common than thought in general pop.
cell.com/cell/fulltext/…
in @CellPressNews
AND on the fact that IEIs are likely more common than thought in general pop.
cell.com/cell/fulltext/…
in @CellPressNews
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Zach Walsh retweeted
Our newest work from @BizarMd lab is now in print at @CellCellPress! Check out our tweetorial below to learn more about our work establishing a scalable variant classification appraoch for inborn errors of immunity, which has already directly enabled the treatment of a patient!
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Zach Walsh retweeted
We (Mori @MichaelMayMD @DrGManji ) find that in patients with resected pancreatic cancer isolated metastatic recurrence in the liver do worse than those with lung recurrence. We profiled (snRNA+lpWGS) their primaries & made an intriguing observation: nature.com/articles/s4158…
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Thrilled to share the latest work from my PhD in the @BizarMd group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:
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Zach Walsh retweeted
For this week’s #MRFResearchWednesday, we’re spotlighting 2025 Medical Student Grant Awardee @Zwalsh96 of @ColumbiaMed, working in the Izar Lab, with @BizarMd.
His project, “Leveraging T Cell Genetic Variants to Enhance Melanoma Immunotherapies,” explores new ways to improve ts.
Zach shares more about his research:
“T cell immunotherapies, which harness the power of a patient’s own immune system to target and eliminate tumor cells, are becoming an increasingly promising treatment approach for melanoma, including for patients who do not respond to immune checkpoint inhibitors. However, many melanoma patients experience relapse or poor response after receiving these therapies, which highlights the critical need to engineer improved T cell therapies.
As part of the Izar group at Columbia, my work aims to address this important gap."
Read more about his work here: melanoma.org/news-press/mrf…
His project, “Leveraging T Cell Genetic Variants to Enhance Melanoma Immunotherapies,” explores new ways to improve ts.
Zach shares more about his research:
“T cell immunotherapies, which harness the power of a patient’s own immune system to target and eliminate tumor cells, are becoming an increasingly promising treatment approach for melanoma, including for patients who do not respond to immune checkpoint inhibitors. However, many melanoma patients experience relapse or poor response after receiving these therapies, which highlights the critical need to engineer improved T cell therapies.
As part of the Izar group at Columbia, my work aims to address this important gap."
Read more about his work here: melanoma.org/news-press/mrf…
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Zach Walsh retweeted
We validated screen results and phenotypes using T cells from two APDS patients with variants mapping to structural GOF hotspots flagged by our screen, directly linking screen data to real disease.
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Zach Walsh retweeted
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment: Cell cell.com/cell/fulltext/… Thrilled to see this transformative paper published- and so sad that its NIH funds are frozen!
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Great to see our work featured by @ColumbiaMed!
New Method Speeds Diagnosis of Rare Genetic Disease cuimc.columbia.edu/news/new-metho…
New Method Speeds Diagnosis of Rare Genetic Disease cuimc.columbia.edu/news/new-metho…
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Zach Walsh retweeted
Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment dlvr.it/TLT5Xf
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Thrilled to share the latest work from my PhD in the @BizarMd group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:
Excited to share a new paper: tinyurl.com/49u5e6by @CellCellPress: a framework to accelerate variant classification, diagnosis & treatment of immune disorders & genetic disorders more broadly. Led by superstar, juggernaut & future dermatologist @zwalsh96
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Zach Walsh retweeted
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment @CellCellPress @BizarMd @joshuamilner2 @FrangiehChris @zwalsh96
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
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Excited to be presenting more of our scalable variant classification work tomorrow at @ImmunologyAAI #IMMUNOLOGY2025. Check it out if you are interested in #CRISPR base editing, forward genetic screening, or immunogenetics! My talk starts at 8:45 AM tomorrow (May 5) in Room 312!
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Truly amazing experience to get to present our variant reclassification work at the opening plenary session of @ClinImmSoc 2025. Couldn’t have asked for a better audience for this work, as evidenced by so many insightful questions and conversations!
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Work that was made possible by brilliant mentorship from @BizarMd, invaluable contributions by @FrangiehChris, Clarissa Heck, @JCA_Melms, @NeehaKothapalli among many others, and invaluable guidance and support from our field-leading collaborators @joshuamilner2 and @BogunovicLab
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Had a wonderful experience presenting our work developing a scalable variant classification approach for inborn errors of immunity at @JointMeeting @the_asci @A_P_S_A last week! And very grateful to have received a travel award to support my attendance.
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Very excited to have received the notice of award for my F30 MD/PhD fellowship from the NCI today! Much thanks to my mentor @BizarMd and excited to continue our work at the nexus of cell therapy and genome engineering
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