Canonical and noncanonical autophagy in immunity: Immunity cell.com/immunity/fullt…

Canonical and noncanonical autophagy in immunity sciencedirect.com/science/articl…

A labor of over two years - summarizing canonical and noncanoncial autophagic processes in immunity and disease. It defines expanding ares of growth where aspiring young scientists can make their mark.

📣Meet Our Editor-in-Chief: Prof. Vojo Deretic @vpderetic

U&A aims to be a broad scientific home for the study of any type of biological system that utilizes ubiquitin, Atg8s, or other ubiquitin-like molecules. Feel free to reach out with questions and submit your manuscripts

x.com/UA_Journal. Follow Ubiquitylation & Atg8ylation jorunal for latest in thsi cutting edge scientific area. The journal covers ubiquitin-like protein modifications with special emphasis on ATG8s and membrane atg8ylation.

Membrane atg8ylation and autophagy in protection against Mycobacterium tuberculosis. J Immunol. 2026 Feb 9;215(2):vkaf359. doi: 10.1093/jimmun/vkaf359. PMID: 41732089; PMCID: PMC12980545.
Free access on pubmed.ncbi.nlm.nih.gov/41732089/

Membrane atg8ylation and autophagy in protection against Mycobacterium tuberculosis 
The Journal of Immunology, Volume 215, Issue 2, February 2026, vkaf359, doi.org/10.1093/jimmun…

Please enjoy reading this U&A point article sciltp.com/journals/ua

A thought-provoking highlight:

ATG16L strikes again! New findings link lysosome stress and physiology rupress.org/jcb/article/22…

There is more to human ATG16L1 than its role in #autophagy or membrane #atg8ylation. It turns out that ATG16L1 controls assembly & activity of H+ pump V-ATPase ensuring normal acidification of #lysosomes.

ATG16L1 controls mammalian vacuolar proton ATPase rupress.org/jcb/article-ab…

Everyone interested in #autophagy knows that #ATG16L1 is an E3 ligase for membrane #atg8ylation sometimes directed by V-ATPase. A new study shows the reverse - that ATG16L1 inhibits V-ATPase actity.

ATG16L1 controls mammalian vacuolar proton ATPase rupress-org.libproxy.unm.edu/jcb/article-ab…

A great in person 2025 AIM symposium. A big “thank you” to keynote speakers for world class talks and content and to all participants. Images are from meeting sessions.

Electronic version of the atg8ylation book is now available - QR code

A new edition of #Biorender generated images of #membrane atg8ylation with callouts showing how #lipid bilayers are modified by mammalian #ATG8 proteins (#LC3 is one of them). Of interest to all #biomedical research including #autophagy aficionados.

app.biorender.com/profile/templa…

Dr. MARINA GARCÍA MACIA, just gave an excellent talk in AIM center’s TAIMs seminar series.
"Autophagy role in the brain-to-periphery axis"
Dr Garcia Macis is in Spain and is a member of AIM’s extraordinary group of international raising talents (COIR)
COIR questions -contact us

The book ‘Atg8ylation and its manifestations’ Cambridge Scholars Publishing, is now available electronically – online via Google Play.

books.google.com/books?id=Av1LE…

check thsi out - app.biorender.com/biorender-temp…

IF you want to know who controlls all stages of autophagy read this doi.org/10.1083/jcb.20…

A model of ATG9A roles in consecutive stages of the canonical #autophagy pathway. Javed, @vpderetic and colleagues @AIM_autophagy show that ATG9A facilitates closure of mammalian autophagosomes. hubs.la/Q031lGDQ0

#Biochemistry

ATG9A is a weaving loom of #autophagy. doi.org/10.1083/jcb.20…

Go ahead, satisfy your curiosity: Not only does #ATG9A contribute to phagophore formation but it works hard until the very end to close nascent phagophores and form the double membrane #autophagosome.