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For people asking about the correct Epitalon dosage - no one knows.
When Khavinson started his studies in Russia, he was testing the hypothesis that pineal gland extracts worked in humans. He used a specific extraction process and obtained a mixture of amino acids. He called that mixture Epithalimin.
He administered 10 mg of Epitalimin for 10 days to different patients etc, and those studies lasted 6–15 years.
During the course of those studies, his team isolated the active ingredient of epitalimin, which is epitalon.
And that was administered at 1000 times less.
So 10 ug per day for 10 days of epitalon was equivalent to the 10 mg epitalimin studies.
But his multi year studies were still ongoing with the pineal gland extracts, so he didn’t change those. But regardless, the dosing for peptides is not really known.
When Khavinson started his studies in Russia, he was testing the hypothesis that pineal gland extracts worked in humans. He used a specific extraction process and obtained a mixture of amino acids. He called that mixture Epithalimin.
He administered 10 mg of Epitalimin for 10 days to different patients etc, and those studies lasted 6–15 years.
During the course of those studies, his team isolated the active ingredient of epitalimin, which is epitalon.
And that was administered at 1000 times less.
So 10 ug per day for 10 days of epitalon was equivalent to the 10 mg epitalimin studies.
But his multi year studies were still ongoing with the pineal gland extracts, so he didn’t change those. But regardless, the dosing for peptides is not really known.
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Google ruined its core search product with endless sponsored ads, various forms of google local garbage and other Google spam while not actually making search better just to milk their monopoly and then the most vicious competitor of all came along and people had the choice of searching with ChatGPT or a Google that was just a gross ads page.
Imagine if Google spent last 10 years actually trying to make the site better for their users - I could see a world where people would much rather use AI through Google.
Imagine if Google spent last 10 years actually trying to make the site better for their users - I could see a world where people would much rather use AI through Google.
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Google knows AI is killing their core product so they've shifted from "don't be evil" to "be evil" while they ride it out
As someone who has personally spent $500k / mo+ on Google Ads for years, I can tell you with certainty:
This revenue growth in Search is artificial & extremely unhealthy for Google’s business long term
Search volumes are declining as legacy search is being increasingly cannibalized by non-monetized LLM queries
Google’s response?
Manufacture revenue growth via short-sighted, highly extractive, customer-hostile tactics. I.e. charge advertisers more for lower quality clicks, including clicks they do not want and explicitly did not approve Google to charge them for
A few examples to illustrate:
For all of its history until recently, Google operated on a 2nd price auction model
I.e. if you bid $5 CPC and the next highest bidder bids $1 CPC, Google charged you $1.01 for the click (one penny more than the 2nd highest bidder) rather than the $5 you bid
This was a genius move by Google early on as it incentivizes advertisers to input their true maximum willingness to pay rather than trying to play the game of bidding low and constantly adjusting to try to stay just ahead of the next highest bidder while still not paying too much
However recently, Google silently deprecated the 2nd price auction and began charging advertisers as much as their bid and budget caps allow, regardless of what anyone else is bidding
It’s a short-sighted cash grab at the expense of the long term health of the advertiser ecosystem
Making thing worse, Google also recently nerfed keyword targeting precision
Google previously had precise keyword targeting settings that allowed advertisers pick individual search phrases to bid on, defined down to the character w/ exact match or phrase match targeting
This was one of the core features that made search advertising magic, enabling advertisers to run extremely precise campaigns based on exactly what their target customer typed
But now, even if you bid on a specific term or phrase using the strictest exact
-match targeting settings, Google will show your ad across 1000’s of unrelated keywords, labeling them as as “exact match (close variant)”
The definition of “close variant” means whatever they want it to and changes constantly. The result is advertisers get billed for clicks that are totally irrelevant to their business and that their targeting settings explicitly forbid Google from targeting. Google does it anyway and there’s no ability to turn this off
So now exact match is broad match, and broad match is just meaningless spam
This is all very bad for advertisers, but for Google, it allows them to show your ad and bill you for clicks across 1000x more searches that were previously going unmonetized (mainly because they’re garbage queries no one wants)
This is how you grow revenue atop declining search volumes
Lastly, and perhaps most egregiously, Google quietly stopped respecting budget caps by a factor of 2x. For example campaigns we’ve been running for years with $1000 daily budget caps suddenly began spending $2000+ per day
And the extra spend is entirely on the garbage keywords Google arbitrarily throws in as “exact match (close variants)” which have no value to our business, but can’t be turned off
Google offers no refunds nor any recourse for overspend or spend on keywords you explicitly did not target
These are not the actions of a healthy business. These are the actions of company whose core business is in decline but desperately needs to pump quarterly earnings so Wall Street will continue to fund insane capex while hopefully looking through their rapidly deteriorating negative free cash flow
Google operated a benevolent monopoly for the better part of 25 yrs
Meaning the value Google captured from Search was but a small fraction of the value it created, and that spread produced a potential energy that justified expectations of high earnings growth far, far into the future
This is now no longer the case
At the alter of AI capex, Google is sacrificing the golden goose
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Tiktok memed an entire generation of teenagers into using sunscreen 365 days a year, that might be the biggest impact of the platform to date.
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Core Google Search is cooked - ChatGPT will dominate
Tesla will crush them in self driving
Chrome will go down next
Youtube will remain dominant.
Gmail - unsure?
Android - clock is ticking
Tesla will crush them in self driving
Chrome will go down next
Youtube will remain dominant.
Gmail - unsure?
Android - clock is ticking
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The Economist bends the knee (in log scale).
What the chart should look.
And this is already minimized the their definition of British population
What the chart should look.
And this is already minimized the their definition of British population
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One great thing about X is everyone sees the same posts.. Elon, Ken Griffin, Bezos, Thiel have the same feed as us - if you write a banger, they will read it too.
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When everyone’s chat logs are inevitably hacked and leaked I am super curious to find out who has the darkest stuff in there
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@nikitabier X should really have a way to click on an image like this and make it full size/full screen
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I still find it kind of staggering that 90% of all coding work done the last 50 years was kind of effort because a machine could write it now in 1/10,000th the time.
Surprised more engineers aren't having an existential crisis.
Surprised more engineers aren't having an existential crisis.
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David Petersen retweeted
Wow! Delta Airlines has a Starlink tracker now too! Total game changer!!
deltastarlinktracker.vercel.app
deltastarlinktracker.vercel.app
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US oil industry is producing a record 14.25 million barrels a day, about $350 billion a year. (Saudi Arabia produces about 9 milion.)
Anthropic + OpenAI are projecting about $350 billion in 2028 revenue.
Anthropic + OpenAI are projecting about $350 billion in 2028 revenue.
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Thanks @WholeFoods for selling me all this garbage for so many years!
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There is going to be a preference cascade from imessage to whatsapp over the next couple years (everyone is already starting to prefer it in the big cities) and it will not be great for apple as they fall further and further behind on AI integration into the OS.
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