Very excited to share our latest publication! We discovered a nuclear metabolic pathway that fuels acetylation of histones from alpha-ketoglutarate, driving chromatin accessibility. @RoswellPark this study was led by Abhisha, now postdoc at UPenn. rdcu.be/frKhe
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We report that TCA cycle enzymes aconitase 2 (ACO2) and isocitrate dehydrogenase (IDH2) are present in the nucleus bound to the histones, where they catalyze the reductive carboxylation of alpha-ketoglutarate to generate nuclear acetyl CoA for histone acetylation.
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Excellent collaboration with Leah and Peder @cwru Reddy Putluri and Sung Yun Jung @BCMFromtheLabs and Roswell collegues @SmiragliaLab @JacobiJustine Prashant Song Liu Mark Long and Katiya Gurova.
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Subhamoy Dasgupta Lab retweeted
A tour de force by Raviprasad Kuthethur and amazing collaborations from Petr Cejka, Shyam Sharan and Krishna Mohan Poluri labs. Thanks a lot to Safa Nasrin, Satheesh Kumar Sengodan, Stefan Braunshier, Carmen Fonseca , Nupur Nagar, Ananya Acharya for putting it all together.
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Subhamoy Dasgupta Lab retweeted
Join us in India for an exciting meeting on mitochondria in health, disease, and aging, Oct 9 to 11, 2025, at Manipal University, Manipal.
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Congratulations @SounakSahu
Fascinating story!
Fascinating story!
Excited to share our latest study in @Nature! We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! @ShyamKSharan @theNCI
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Subhamoy Dasgupta Lab retweeted
The best part of the #AACRtumorenviron24 meeting was exchanging ideas with this great group of #scientists. Excited for the future of
#CancerResearch and the impact we can make together!
@AACR @caoresco @Marcus_Ruscetti @subhamoy_d @PeterMKWestcott @TheFeiginLab #AACRTME
#CancerResearch and the impact we can make together!
@AACR @caoresco @Marcus_Ruscetti @subhamoy_d @PeterMKWestcott @TheFeiginLab #AACRTME
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Last week we bid farewell to Tao Dai, graduating with a PhD in Tumor Immunology and ‘Excellence in Dissertation’ award from @RoswellPark. Tao will soon change his “NY-GLUCOSE” plate to TX, as he begins as a Postdoc under the mentorship of @RJDLab @UTSWCancerBio. All the best Tao!
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Subhamoy Dasgupta Lab retweeted
Very excited to share this work led by @MarlousKamp
and the @bondieklab where we managed to visualise fumarate in label free conditions, and at intracellular resolution! congrats to all!
nature.com/articles/s4146…
and the @bondieklab where we managed to visualise fumarate in label free conditions, and at intracellular resolution! congrats to all!
nature.com/articles/s4146…
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Subhamoy Dasgupta Lab retweeted
Happy to share our new paper in print today in @ScienceAdvances exploring nutrient utilization by CD8 T effector cells in vivo using infusion of 13C tracers. Great work by Eric Ma, Mike Dahabieh and collaborators at @VAInstitute and @AgiosPharma. science.org/doi/10.1126/sc…
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Bittersweet moment for us, as we bid farewell to @AbhishaSD -Dr. Sawant Dessai, first graduate student from the lab. Abhisha will begin her postdoctoral training @berger_lab. All the best Abhisha, you will be missed @RoswellPark!
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In collaboration with Dr. Mukund Seshadri lab @RoswellPark we report how to take advanatage of photoacoustic imaging to study the impact of hypoxia on tumor microenvironment. Congrats to co-first authors Tao Dai and Laurie Rich.
Online now: Protocol to detect and quantify tumor hypoxia in mice using photoacoustic imaging dlvr.it/T5DnrN #protocol #starprotocols #cellpress
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Subhamoy Dasgupta Lab retweeted
9 spots left and then it will be a waiting list. If you signed up, please complete your registration online.
Places are filling up fast so do not leave it to the last minute!!
grc.org/mammary-gland-…
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Subhamoy Dasgupta Lab retweeted
I am pleased to share the final version of our Human Breast Cell Atlas with @MarioniLab now out @NatureGenet. There are important new additions, which I will leave to @Dr_SaraPensa and @AustinDReed to mention👇 . Couple of points i want to highlight 👇:
nature.com/articles/s4158…
nature.com/articles/s4158…
I am very pleased to share our second and largest contribution to “The Human Breast Cell Atlas” (HBCA) project. Buckle up a longish thread ahead!
biorxiv.org/content/10.110…
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Thanks Rusty for your outstanding talk and serving as Tao’s external reader. We really appreciate it. Great to catch up with you @LOlejniczak
Congratulations to Dr. Tao Dai from @RoswellPark for successful defence of his thesis this week. It was an honour to serve as external examiner. Your future is bright!
Also Best licence plate in western NY state. #glucose
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