Pinned Tweet
Our latest manuscript is finally out in @NatureSMB!
Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels.
nature.com/articles/s4159…
Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels.
nature.com/articles/s4159…
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Lucas Tafur retweeted
🧬 How do bacteria open a molecular ring to start DNA replication?
Excited to share our new work in NAR @OxUniPress, where we reveal how the ancestral helicase loader DciA opens the bacterial replicative helicase DnaB.
@CIB_CSIC
academic.oup.com/nar/article/54…
🧵👇
Excited to share our new work in NAR @OxUniPress, where we reveal how the ancestral helicase loader DciA opens the bacterial replicative helicase DnaB.
@CIB_CSIC
academic.oup.com/nar/article/54…
🧵👇
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Lucas Tafur retweeted
Glutamine + chemo in pancreatic cancer: Phase 1 GlutaPanc, n=16, 81% cachectic at baseline. 30g/day oral glutamine + full-dose gem/nab-paclitaxel, no glutamine DLTs. ORR 44%.
nature.com/articles/s4301…
nature.com/articles/s4301…
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Lucas Tafur retweeted
🚨 New paper from the Bustamante Lab in @NatureComms! Our study reveals how the central coupler of ClpXP helps coordinate its subunits to convert chemical energy into mechanical force
Check it out! 👇
doi.org/10.1038/s41467…
Check it out! 👇
doi.org/10.1038/s41467…
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Lucas Tafur retweeted
Today, our work in partnership once again with @SternbergLab presenting the structures of several DRT10 bacterial defense systems and comprehensive analysis of their mechanisms of action is published… very happy!
Great work guys!
nature.com/articles/s4158…
Great work guys!
nature.com/articles/s4158…
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Lucas Tafur retweeted
Interested in cancer metabolism? We have a 4y FPI-funded PhD student position available in my lab to study the metabolic interplay of cancer cells and their microenvironment.
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Lucas Tafur retweeted
Happy to see our paper, led by outstanding postdoc Alessandra Esposito, out in @Nature today. We uncovered a TBK1/ULK1 signaling pathway that acts as a lysosome quality control mechanism, regulating the FLCN-TFEB axis in response to lysosomal stress
Link: rdcu.be/icEViqq6F68a
Link: rdcu.be/icEViqq6F68a
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Lucas Tafur retweeted
No es que no estén validados (que no lo están), es que su fundamento científico es entre endeble y nulo, más cerca de nulo, a día de hoy.
👏🏻👏🏻
“No tiene ningún sentido hacerse test de microbiota, no están validados” @rosacampo agenciasinc.es/Entrevistas/No…
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Lucas Tafur retweeted
Why do muscle fibres shrink with age?
Not because myofibrils get smaller — because there are fewer of them.
We followed this from whole-muscle down to individual myofibrils, in humans and mice, across ageing and disuse.
Tweetorial below
Open Access here: physoc.onlinelibrary.wiley.com/doi/10.1113/JP…
Not because myofibrils get smaller — because there are fewer of them.
We followed this from whole-muscle down to individual myofibrils, in humans and mice, across ageing and disuse.
Tweetorial below
Open Access here: physoc.onlinelibrary.wiley.com/doi/10.1113/JP…
1/ Why do muscles atrophy with aging and disuse?
Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils?
In our new study, we addressed this in humans and mice. biorxiv.org/cgi/content/sh…
Full breakdown of the findings in this thread 👇
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Lucas Tafur retweeted
Finally a more intuitive way to learn pLDDT/pAE? 😎
sokrypton.github.io/protein_fighte…
(Character idea from @HannesStaerk & Alex Waldherr)
sokrypton.github.io/protein_fighte…
(Character idea from @HannesStaerk & Alex Waldherr)
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CICO 🥴
Bottom line: not all carbohydrates are the same when it comes to immunity. Refined starch, the dominant carbohydrate in processed foods, appears to be an unrecognized driver of inflammation after weight loss. cell.com/cell-press-blu…
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Lucas Tafur retweeted
This is legitimately terrible for OpenAI --- but also Anthropic --- and it relates to their work in drug discovery.
I read this as: prompts will be monitored and potentially acted on if we think there’s something scientifically and/or commercially valuable being disclosed.
Now, the big problem for Anthropic is that they are increasingly seen to be competing with their customers. Outside of SF, many people also think of OpenAI/ChatGPT and Anthropic/Claude as somewhat interchangeable companies and products --- aka, if OpenAI do something, surely Anthropic will do it too?
As so much IP relates to drug targets and people disclose these to Claude, I think we will see a lot of pharma companies stop using these tools or put up a lot of internal guardrails.
I read this as: prompts will be monitored and potentially acted on if we think there’s something scientifically and/or commercially valuable being disclosed.
Now, the big problem for Anthropic is that they are increasingly seen to be competing with their customers. Outside of SF, many people also think of OpenAI/ChatGPT and Anthropic/Claude as somewhat interchangeable companies and products --- aka, if OpenAI do something, surely Anthropic will do it too?
As so much IP relates to drug targets and people disclose these to Claude, I think we will see a lot of pharma companies stop using these tools or put up a lot of internal guardrails.
wtf is this way to handle mathematicians work and scientific communication
TLDR: Leven and Tristan worked over several months on one of the Millenium Prize Problems with various AIs to reach final interesting results. OpenAI apparently heard about it in the last days and odels to work on the direction Leven and Tristan found fruitful. They then tried to push for controlling communication of the result and dropping Leven from authorship with some very bad taste social pressure.
Hope this is not a glimpse of the future we’ll get in science research with these dominating players playing marketing games hurtful for the real scientific community.
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Vegan diet = highly increased risk of fraility, particularly for older adults.
A self-selected vegan diet reduces skeletal muscle mass in healthy older adults: a randomized controlled trial
sciencedirect.com/science/articl…
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Luckily we are in 2026 and people are not afraid to call BS on things like this anymore.
Community noteArday was an academic fraud whose life story was fake. Editorial falsely treats former as unproven allegation, omits mention of latter, defames those who covered the scandal as racist. Calls him "autistic Black scholar" despite no proven autism diagnosis.
substack.com/@nathancofnas/…
theguardian.com/education/ng-i…
thetimes.com/uk/education/a…
news.educ.cam.ac.uk/230223-jason-a…
bbc.com/news/articles/…
bbc.com/news/uk-englan…
youtube.com/shorts/4kLRJvR…
youtube.com/watch?v=g28uXe…
youtube.com/watch?v=FA78tV…
x.com/benryanwriter/…
x.com/benryanwriter/…
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Lucas Tafur retweeted
Guys we need to get serious here: The new paper barely nudges our priors on GLP-1 for longevity.
I'm spending every waking moment pushing for progress on longevity, but what's going to get us there is scaling up truth-seeking, not giving in to slopulism.
Publishing this in of human taste and judgement.
First, the sema mice don't really live longer than healthy controls in other studies (see pic). If you stop there, this should be seen as 'nice someone did this, now do it more carefully'. This may be robust life extension it may not.
Second, we already know reduced food intake extends mouse lifespan. Why is there are whole figure comparing CR and sema effects, but no lifespan for matched food-intake? Because it should turn paper into 'sema reduces mouse food intake'
If you want to keep going, why females only? Blah blah male aggression, that doesn't stop various ITP interventions from working in males.
Or is it that constant injections shorten lifespan, possibly via ulcerative dermatitis which is more common in females? No non-injected control group, can 't say.
Fig 3 "GLP-1 ... alleviates the hallmarks of ageing and mimics the calorie restriction response" yes reducing food intake is similar to reducing food intake.
Fig 4 "modulates the genetic regulators of ageing" -> Show a bunch target genes many of which have been tested and don't nudge lifespan.
I'm glad someone did this study, I'm not saying it's not a contribution or should be retracted, but the reason this is in a tier 1 journal is because it'll get attention (boosted by hypefluencers). Apparently some journals are just giving up; I understand that the multi-year assault on truth-seeking is really hard, it's hard to imagine journals not getting replaced by AI if they lean into slopulism.
I'm spending every waking moment pushing for progress on longevity, but what's going to get us there is scaling up truth-seeking, not giving in to slopulism.
Publishing this in of human taste and judgement.
First, the sema mice don't really live longer than healthy controls in other studies (see pic). If you stop there, this should be seen as 'nice someone did this, now do it more carefully'. This may be robust life extension it may not.
Second, we already know reduced food intake extends mouse lifespan. Why is there are whole figure comparing CR and sema effects, but no lifespan for matched food-intake? Because it should turn paper into 'sema reduces mouse food intake'
If you want to keep going, why females only? Blah blah male aggression, that doesn't stop various ITP interventions from working in males.
Or is it that constant injections shorten lifespan, possibly via ulcerative dermatitis which is more common in females? No non-injected control group, can 't say.
Fig 3 "GLP-1 ... alleviates the hallmarks of ageing and mimics the calorie restriction response" yes reducing food intake is similar to reducing food intake.
Fig 4 "modulates the genetic regulators of ageing" -> Show a bunch target genes many of which have been tested and don't nudge lifespan.
I'm glad someone did this study, I'm not saying it's not a contribution or should be retracted, but the reason this is in a tier 1 journal is because it'll get attention (boosted by hypefluencers). Apparently some journals are just giving up; I understand that the multi-year assault on truth-seeking is really hard, it's hard to imagine journals not getting replaced by AI if they lean into slopulism.
New paper @Nature: Semaglutide recapitulates many of the benefits of caloric restriction in female mice & extends lifespan by almost 100 days. Males not yet tested for lifespan
Below: Red traces = mouse movement
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Lucas Tafur retweeted
New paper in @MolecularCell! A great collaborative effort to uncover how the lncRNA CONCR works. Terrific teamwork with the labs of @MaiteHuarteLab @OscarLlorcaCNIO @ChillonIsabel and supported by @FundlaCaixa cell.com/molecular-cell…
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Lucas Tafur retweeted
Un conflicto de interés de enormes dimensiones acaba de ser descubierto: un cardiólogo presidente de la sociedad europea promovió y recomendó el uso de un medicamento sobre el cual existen dudas de su seguridad y eficacia, y recibió 50M£, via @bmj_latest
bmj.com/content/394/bm…
bmj.com/content/394/bm…
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Exactly my experience. Many mistakes are made. AI agents replace only a quick web search, not in depth review of the literature.
I keep reading on Twitter that AI has replaced mathematicians. I'm not qualified to comment on that. However, I can tell you that AI definitely has not replaced biologists. In every conversation I have where the topic is one I know well, the AIs make very signficant errors:
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