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What happens when you suddenly remove half of an essential enzyme from cells? 🤔

We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.

Our lab's new preprint 👇

bit.ly/4pyPgax
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Replying to @scottbscience
This fun project was driven by the talented and rigorous Alex Gillis @acftbl, in wonderful collaboration with @ana_tufegdzic lab!
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📢 New paper from the lab!

In a fantastic new collaboration with @ana_tufegdzic lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta @caciopporobi, Alex @acftbl, Ivan @IvanShlamovitz, and Andrew.

cell.com/molecular-cell…
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Replying to @scottbscience
Thanks to support from @SingMolSci and @UNSWRNA
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Replying to @scottbscience
Also take a look at complementary work by
@SvejstrupLab:
sciencedirect.com/science/articl…
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Was a pleasure working with @ana_tufegdzic on this!
The first paper from our lab is online! A wonderful collaboration with @scottbscience lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! 🧵
cell.com/molecular-cell…
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Scott Berry retweeted
Global transcription regulation revealed from dynamical correlations in time-resolved single-cell RNA sequencing @CellSystemsCP
@DVolteras
@VShahrezaei
doi.org/10.1016/j.cels…
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My group is looking for new PhD students! Australian and International applicants welcome.

findaphd.com/phds/project/r…
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Scott Berry retweeted
Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
authors.elsevier.com/c/1jMoV3vVUPRm…

Published @MolecularCell

Big thanks to
fellow co-first authors @BrendanSmalec Albert Xu
@stephenfloor
mentor @fiddle
+team!
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Scott Berry retweeted
We were selected for the cover! our papers under the spotlight in the current issue of @MolecularCell. Congratulations to Govind Menon for his beautiful design 😍☺️
Check out our latest issue here: cell.com/molecular-cell…
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Scott Berry retweeted
Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published
nature.com/articles/s4158…
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Scott Berry retweeted
1/2 The @nswdpi pilot project to fast-track an mRNA vaccine for border disease virus (BDV) has been successfully manufactured for the first time in NSW by the @UNSWRNA.
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Scott Berry retweeted
We at the @UNSWRNA team are very proud of this that @dpinsw led! First batch of an animal mRNA vaccine that was made here in Australia by us in March in collaboration with @Tibabiotech who developed this vaccine. #mRNA
1/2 The @nswdpi pilot project to fast-track an mRNA vaccine for border disease virus (BDV) has been successfully manufactured for the first time in NSW by the @UNSWRNA.
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Scott Berry retweeted
Australian PhD candidates & Early Career Scientists, don’t miss this opportunity to participate in a dedicated 2 day program in the lead up to Biomolecular Horizons 2024. Connect with colleagues from across the globe! Visit bmh2024.com Applications close 29 Feb 2024
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