Combining MRI-guided sampling with molecular profiling, the study reveals how dysregulated PKA signaling distinguishes clinically significant prostate cancer. Read more >>>>
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New study shows early transcriptional and #immune signatures distinguished responsive from resistant TNBC tumours days before measurable changes in tumour volume
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SIRT3-SLC25A13 signalling axis controls NAD⁺/NADH homeostasis and mitochondrial dysfunction-associated senescence (MIDAS) nature.com/articles/s4138…

New research reveals how #LiverCancer cells evade immune defenses by altering fatty acid uptake. Loss of FATP5 causes fat accumulation in neighboring blood vessel cells, triggering immune exhaustion and tumor progression.

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New research reveals how #GastricCancer cells exploit fatty acid uptake to fuel tumor growth.

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Analysis of 15,000+ colorectal tumors reveals strong links between cellular trafficking and cancer signaling. Low AP2M1 expression was associated with nearly doubled survival in cetuximab-treated #ColorectalCancer patients.

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Could targeting cancer cells’ energy supply help treat #glioblastoma?

New research shows that combining two experimental drugs damages mitochondria, disrupting tumour cell energy production and extending survival in mice.

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#BrainCancer #CancerResearch

How do drugs targeting KRAS affect cancer cell behaviour?

New research shows that two different KRAS inhibitors disrupt similar protein interactions, including those involved in cell movement, suggesting potential to limit cancer spread.

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New research identifies the IGF2BP1–METTL21A–SOX18–CXCL12 signalling axis as a key driver of lymphatic #metastasis in gastric cancer, revealing potential therapeutic targets to prevent cancer spread.

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#GastricCancer #CancerResearch

Study reveals that TNFα drives TIGIT expression in immune cells through epigenetic regulation, while dual #TNFα and TIGIT blockade enhances antitumor immunity and survival in mouse models, suggesting a promising cancer #immunotherapy strategy.

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New research reveals that PTK7 promotes DNA repair and immune evasion in triple-negative #BreastCancer, while its inhibition enhances anti-PD-1 #immunotherapy responses in preclinical models, identifying a promising therapeutic target 💊🎯.

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New study identifies adrenomedullin 2 (ADM2) as a key driver of cancer cell invasion, entry into blood vessels and #metastasis, highlighting a potential therapeutic target to prevent cancer spread.

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#OpenAccess

New research identifies SMCO2 as a previously uncharacterised regulator of ER–mitochondrial communication in adenocarcinomas.

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#CancerResearch #Ferroptosis #Mitochondria

KDM4A is a critical #epigenetic regulator of #TesticularCancer metastasis

Read more here👇
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Oxaliplatin lowers TFAM, causing mitochondrial DNA to leak into the cytosol and activate STING–TBK1 signaling, which increases protective lysophagy and promotes #DrugResistance

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#ColorectalCancer

Quinacrine induces DNA damage by downregulating several DNA repair proteins, leading to the inhibition of homologous recombination repair through nuclear #cathepsin L

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#OpenAccess #OvarianCancer

A novel ACTB–YTHDC2–AKT–#mTOR regulatory network that integrates transcriptional and epitranscriptomic control in #EsophagealCancer

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#ESCC #OpenAccess

Latest study identifies DDR1 as a master regulator of iron metabolism and ferroptosis resistance in PDAC. Read more>>>
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New work reveals how SMAD4 helps maintain the 3D structure of the genome, and how its loss rewires enhancer-promoter interactions to drive lung cancer
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New study finds a stress-responsive JNK-UBR5-CDC73 signalling axis that safeguards the tumour suppressor CDC73, reshapes chromatin accessibility and transcriptional programmes, and suppresses osteosarcoma progression.
Read more:
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