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My great-great uncle Meyer Jacobstein en.m.wikipedia.org/wiki/Meyer_Jac… was a 3-term Congressman from Rochester & opposed the Immigration Act of 1924
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With apologies to The Graduate, I’ve got one word for you, kid: peptides.
Today we’re announcing that @spc led the $6M pre-seed round in LionBio, a consumer biotech company building the next generation of peptide medicines. Congrats to founding CEO @zebird0, scientific co-founder e team.
When people talk about the magic of modern medicine, they talk about the molecule: the drug that hits the target, melts the tumor, or fixes a broken pathway.
Almost nobody talks about how the drug gets where it’s going. Does the stomach destroy it first? Can it reach the brain? Does it last six hours or a week? Does it make you nauseous?
Hitting the right target isn’t enough. GLP-1s prove it. The molecule boosts insulin and quiets appetite, and it’s reshaping medicine. It also comes as a weekly injection, and many patients quit because of the nausea.
Drug delivery is the problem Robin founded LionBio to solve.
Robin is commercializing Kam’s foundational biomaterials work at Columbia: a novel nanoparticle wrapper that lets large peptides cross the lining of the nose. (Just don't call it Nosempic).
Is it critical to deliver a drug through your nose? Yes, as it turns out. No needle, for one thing. Taking a weekly shot sucks. And who loves disposing of their sharps?
The (daily, or even real-time) ease of intranasal delivery means doses can be (much) lower, and the nose is a side door to the brain, connecting directly via the olfactory and trigeminal nerves and partly bypassing the blood-brain barrier.
These advantages should reduce side effects, a real problem for many GLP-1s.
More importantly, the connection to the brain may be critical for many neuroactive peptides. There is, for example, early but promising data regarding the ability of peptides to act on addictions of all sorts, from nicotine to alcohol and beyond.
These advantages allow LionBio to build a nanoparticle platform for neuropeptide delivery.
Robin is uniquely qualified to lead this business, as LionBio requires frontier materials science, preclinical translation, clinical development, manufacturing, and consumer marketing.
Special thanks to Sahil Sud for the introduction.
At SPC, we love working with founders like Robin and Kam who take on massive technical risk to solve fundamental human problems.
Today we’re announcing that @spc led the $6M pre-seed round in LionBio, a consumer biotech company building the next generation of peptide medicines. Congrats to founding CEO @zebird0, scientific co-founder e team.
When people talk about the magic of modern medicine, they talk about the molecule: the drug that hits the target, melts the tumor, or fixes a broken pathway.
Almost nobody talks about how the drug gets where it’s going. Does the stomach destroy it first? Can it reach the brain? Does it last six hours or a week? Does it make you nauseous?
Hitting the right target isn’t enough. GLP-1s prove it. The molecule boosts insulin and quiets appetite, and it’s reshaping medicine. It also comes as a weekly injection, and many patients quit because of the nausea.
Drug delivery is the problem Robin founded LionBio to solve.
Robin is commercializing Kam’s foundational biomaterials work at Columbia: a novel nanoparticle wrapper that lets large peptides cross the lining of the nose. (Just don't call it Nosempic).
Is it critical to deliver a drug through your nose? Yes, as it turns out. No needle, for one thing. Taking a weekly shot sucks. And who loves disposing of their sharps?
The (daily, or even real-time) ease of intranasal delivery means doses can be (much) lower, and the nose is a side door to the brain, connecting directly via the olfactory and trigeminal nerves and partly bypassing the blood-brain barrier.
These advantages should reduce side effects, a real problem for many GLP-1s.
More importantly, the connection to the brain may be critical for many neuroactive peptides. There is, for example, early but promising data regarding the ability of peptides to act on addictions of all sorts, from nicotine to alcohol and beyond.
These advantages allow LionBio to build a nanoparticle platform for neuropeptide delivery.
Robin is uniquely qualified to lead this business, as LionBio requires frontier materials science, preclinical translation, clinical development, manufacturing, and consumer marketing.
Special thanks to Sahil Sud for the introduction.
At SPC, we love working with founders like Robin and Kam who take on massive technical risk to solve fundamental human problems.
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Mark Jacobstein retweeted
Excited to share that @nyquishq has raised $6.3M, co-led by @gigascale and @spc.
Like an EKG for the grid, Nyquis helps utilities spot hidden faults and plan for growing demand. We’re already monitoring 800 miles of power lines.
Watch our launch film below.
Like an EKG for the grid, Nyquis helps utilities spot hidden faults and plan for growing demand. We’re already monitoring 800 miles of power lines.
Watch our launch film below.
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Mark Jacobstein retweeted
We’re betting our $5.5M seed round that the next leap in AI coding won’t come from OpenAI or Anthropic.
It’ll come from a new feedback loop that learns from you.
Introducing Beacon: open-source, self-improving memory for coding agents.
Your sessions capture how you debug and that context gets lost and you have to re-explain things every time you switch tools.
Beacon continuously distills your sessions into reusable skills across Claude Code, Cursor, Codex, and 20+ harnesses, so your next agent can learn from the last.
Beacon is free and OSS 🌟 github.com/Asymptote-Labs…
Why should the frontier labs be the only ones winning with your sessions?
You already did the work. Now let your coding agents learn from you.
It’ll come from a new feedback loop that learns from you.
Introducing Beacon: open-source, self-improving memory for coding agents.
Your sessions capture how you debug and that context gets lost and you have to re-explain things every time you switch tools.
Beacon continuously distills your sessions into reusable skills across Claude Code, Cursor, Codex, and 20+ harnesses, so your next agent can learn from the last.
Beacon is free and OSS 🌟 github.com/Asymptote-Labs…
Why should the frontier labs be the only ones winning with your sessions?
You already did the work. Now let your coding agents learn from you.
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I love this metaphor. Like, this needs to go down in the annals like when @aileenlee coined "unicorn"
Jensen’s five-layer cake (energy, chips, infrastructure, models and applications) is an efficient way to describe the intelligence stack, but it’s flawed as a metaphor in my opinion.
Most cakes are uniform all the way across. They have a fixed circumference. The application ike a thin layer of frosting sitting on top of everything else. Its construction and ingredients are known.
What’s happening feels more like a banyan tree growing in time lapse.
1. The canopy keeps branching outward, creating new branches and more leafy area across science, industrials, healthcare, enterprise and consumer. Many of these applications are still impossible to imagine.
2. The different parts of the tree continually change one another. The roots and trunk enable the canopy, but demand and energy from the canopy also flow back down and determine how the system below develops.
3. And most interesting...a banyan’s branches send new roots back into the ground. Those roots become new trunks, which support still more branches.
That last part of the metaphor strikes me as most interesting. The most consequential applications won’t just sit on top of the existing AI stack. They’ll create demand for their own specialized models, infra, compute stack. At some point, an application is no longer just a leaf on a generic stack. It puts down roots and becomes a new stack.
The cake describes the layers. The banyan does a better job describing how this new age of intelligence will evolve.
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It is an extraordinary time for the maximally ambitious: for those who would fundamentally rethink nuclear, space, solar, chips, algorithms, bio, security, or our relationship with the (extremely jagged) intelligent frontier. Better yet, build something so new we don’t yet have a pc, we like to say, “we can just do things.” So we’re trying an experiment.
We’re investing $200K, uncapped, in a handful of “first they call you crazy” ideas, led by profoundly talented founders.
Our community is built to catalyze ambitious people and ideas. We’re experimenting with funding for the same reason.
Bring us your biggest idea. If this sounds like you, let me know below.
We’re investing $200K, uncapped, in a handful of “first they call you crazy” ideas, led by profoundly talented founders.
Our community is built to catalyze ambitious people and ideas. We’re experimenting with funding for the same reason.
Bring us your biggest idea. If this sounds like you, let me know below.
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I'm helping to host (and judge!) a compbio hackathon at @spc this weekend. 24 hours left to sign up to hack this weekend!
Bonus prize for every team: visibility within the @spc ecosystem.
We're teaming up with @AnthropicAI, @awscloud, @biohub, @phylo_bio, @OwkinScience,
Bonus prize for every team: visibility within the @spc ecosystem.
We're teaming up with @AnthropicAI, @awscloud, @biohub, @phylo_bio, @OwkinScience,
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For 15 years, Thinking, Fast and Slow (TFAS) was my standard gift for new hires. I was a product-oriented leader, and great products orchestrate system-one decision frameworks for their users. Along with books like Nudge, it shaped how I wanted products to work.
TFAS is back mind, since @typesafeai dropped JEV. For those who haven’t seen it, JEV is a “System 1” model that ingests unstructured context against a typed schema and returns an evaluation and confidence score. Much like our system one brain, it is very, very fast (and cheap), and usually right.
The implications are huge. Much of intelligence is high-speed “deciding,” not “generating,” and LLMs are an elephant gun for the mouse hunt of most agentic work.
If you’re exploring here, or want to, find me at @SPC, where we’re building the future of compute and intelligence.
TFAS is back mind, since @typesafeai dropped JEV. For those who haven’t seen it, JEV is a “System 1” model that ingests unstructured context against a typed schema and returns an evaluation and confidence score. Much like our system one brain, it is very, very fast (and cheap), and usually right.
The implications are huge. Much of intelligence is high-speed “deciding,” not “generating,” and LLMs are an elephant gun for the mouse hunt of most agentic work.
If you’re exploring here, or want to, find me at @SPC, where we’re building the future of compute and intelligence.
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Dropping some truth with @finn_meeks and our latest cohort of frontier builders at @spc
What an amazing time to build. We're looking at engineered biology, model alignment and interpretability, the future of work, agentic factories, space materials, next-gen compute, and so much more.
What an amazing time to build. We're looking at engineered biology, model alignment and interpretability, the future of work, agentic factories, space materials, next-gen compute, and so much more.
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Sign up here:: southparkcommons.com/bio-data-hacka…
@SPC exists to facilitate catalysis. We bring together the world's brightest, most ambitious frontier builders and push them to change the world.
Our bio-twist on our general thesis will take the form of a bio-hackathon from Oct 16-18. If you're bio-curious and want to hack on extraordinary data w/ exceptional people, please join us.
With @AnthropicAI, @awscloud, @biohub, @OwkinScience, @phylo_bio, & more...
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“Every great advancement in medicine has come from seeing something that was once invisible.”
@Helmy_L2K, CEO of @GuardantHealth, joined me at @spc to talk about the journey from liquid biopsy to early cancer detection, what makes diagnostics such a difficult business, and how w applications far beyond cancer.
@Helmy_L2K, CEO of @GuardantHealth, joined me at @spc to talk about the journey from liquid biopsy to early cancer detection, what makes diagnostics such a difficult business, and how w applications far beyond cancer.
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In diagnostics, building the technology is only one part of the job. Catch more of my conversation with @Helmy_L2K
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Mark Jacobstein retweeted
Over the last two days, we’ve had Qasar from Applied Intuition and Brendan from Mercor at @spc.
Both were invited and hosted by SPC members—Abe Ankumah and @nickmecklenburg. This is SPC at its best.
The magic of SPC is—and always has been—its members.
Both were invited and hosted by SPC members—Abe Ankumah and @nickmecklenburg. This is SPC at its best.
The magic of SPC is—and always has been—its members.
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Mark Jacobstein retweeted
Some will find this demo startling. That's reasonable. What @nuance_ai built is startling.
But it's also a step toward insuring AI is both safe and helpful.
For AI to follow our intent, it needs to understand what we really intend. And what we really mean is in the nuances.
But it's also a step toward insuring AI is both safe and helpful.
For AI to follow our intent, it needs to understand what we really intend. And what we really mean is in the nuances.
We’re excited to share that @nuance_ai has raised a $50M Series A led by @lightspeedvp, joined by @Accel, @spc, @nvidia, and @definevc!
Much of human communication happens beyond words. Before we can speak, we learn to read faces, return smiles, follow gestures, and sense when hat visual and emotional vocabulary stays with us for life.
At Nuance Labs, we’re building a foundation model that understands and responds to the full spectrum of human emotion. A single full-duplex audio-visual model that sees, listens, and responds in real time, with the natural give-and-take of a conversation with a friend or colleague.
We believe the best interface with a machine is the one we’ve practiced since birth.
Join us!
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Mark Jacobstein retweeted
We’re excited to share that @nuance_ai has raised a $50M Series A led by @lightspeedvp, joined by @Accel, @spc, @nvidia, and @definevc!
Much of human communication happens beyond words. Before we can speak, we learn to read faces, return smiles, follow gestures, and sense when hat visual and emotional vocabulary stays with us for life.
At Nuance Labs, we’re building a foundation model that understands and responds to the full spectrum of human emotion. A single full-duplex audio-visual model that sees, listens, and responds in real time, with the natural give-and-take of a conversation with a friend or colleague.
We believe the best interface with a machine is the one we’ve practiced since birth.
Join us!
Much of human communication happens beyond words. Before we can speak, we learn to read faces, return smiles, follow gestures, and sense when hat visual and emotional vocabulary stays with us for life.
At Nuance Labs, we’re building a foundation model that understands and responds to the full spectrum of human emotion. A single full-duplex audio-visual model that sees, listens, and responds in real time, with the natural give-and-take of a conversation with a friend or colleague.
We believe the best interface with a machine is the one we’ve practiced since birth.
Join us!
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I love my job.
Frontier Tech Fall at SPC.
Leaders from @Waymo, @anduriltech, @physical_int, and @AppliedInt are joining us.
Don’t miss out.
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A stitch in time saves nine. Or, with semiconductors, perhaps 99.
When you miss a bug in software, you patch it and catch the next release. Miss one in a chip, and you have to respin the whole thing. That can cost hundreds of millions of dollars. Or more.
SukHwan Lim from TenX explain why silicon has to be right the first time, and how they're remaking chip verification.
When you miss a bug in software, you patch it and catch the next release. Miss one in a chip, and you have to respin the whole thing. That can cost hundreds of millions of dollars. Or more.
SukHwan Lim from TenX explain why silicon has to be right the first time, and how they're remaking chip verification.
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