We have an open #postdoc position to study the molecular mechanisms of #DNArepair !🧬🔬
The project will build on recent findings nature.com/articles/s4158… and established collaborations, using #cryoEM and #SingleMolecule imaging.
Access to fantastic facilities @MRC_LMB .
The project will build on recent findings nature.com/articles/s4158… and established collaborations, using #cryoEM and #SingleMolecule imaging.
Access to fantastic facilities @MRC_LMB .
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Lori Passmore retweeted
CryoEM community: we encourage you to submit applications to the Almeida Award #cryoEM BPS subgroup:
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I presented this work at #EESRNA @embl
@EMBLHeidelberg
An amazing meeting organised by @LabConti @OlivierDuss @torbenheick and Karla Neugebauer!!
@EMBLHeidelberg
An amazing meeting organised by @LabConti @OlivierDuss @torbenheick and Karla Neugebauer!!
New work from the lab!
James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/
#RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
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Unfortunately I had to leave the conference very suddenly and unexpectedly due to a family emergency. I really missed meeting and speaking with so many people. Many apologies - I would be happy to zoom meet with anyone who wants to chat - please drop me an email!
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New work from the lab!
James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/
#RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/
#RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
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The enzymatic machineries of gene expression (deadenylation complexes, RNA polymerases) are highly conserved. .... but the evolutionary plasticity of IDRs found in a multitude of regulators (RNA adaptors, transcription factors) allows rewiring of gene expression programs. 10/
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Great fun with the @RappsilberLab !
Photo-crosslinking improves the contrast of crosslinking mass spectrometry.
Photo-crosslinking improves the contrast of crosslinking mass spectrometry.
New preprint! We show that photo-crosslinking dramatically improves structural insights into protein complexes compared to traditional crosslinking MS methods.
biorxiv.org/content/10.110…
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Very cool structure!
Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem
👇👇👇
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I am really looking foward to working with @SjorsScheres as Joint Head of Structural Studies @MRC_LMB !
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