Pinned Tweet
Delighted to see our latest work out in @J_A_C_S pubs.acs.org/doi/pdf/10.102…. We use kinetics, crystallography and simulation to investigate carbapenem hydrolysis in the versatile KPC-2 beta-lactamase. @Spencer_D60 @Michaelbeer777 @phil_hinchliffe @SchofieldOxford @AdrianMulholla1
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Dr. Catherine Tooke retweeted
Come and join us here in beautiful Bath @lifesciencebath where we have lots of exciting microbiology going on! If you’re in to Microbiomes then have a look at these new positions!
Exciting times in #LifeSciences here @UniofBath and #Microbiome research . 5 adverts have just gone live, incl 2 prof positions - bath.ac.uk/campaigns/join…. Closing date 28 July, please spread the word!
@MilnerCentre @PharmUnivBath @phil1pingham
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Dr. Catherine Tooke retweeted
Out now in @ACSCatalysis, we show that active site electric fields are a determinant of carbapenemase activity in class A beta-lactamases. Led by @AdrianBunzel and Hira Jabeen! @AdrianMulholla1 @marcvanderkamp @Spencer_D60 @SWBio_DTP
pubs.acs.org/doi/10.1021/ac…
pubs.acs.org/doi/10.1021/ac…
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An absolutely stellar morning session on the first day of the Great Wall symposium 2023! ... the location isn't bad either... #GWS2023
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Another #PhD opportunity for Sept 2024 led by @Spencer_D60 to investigate B-lactam antibiotic action and resistance with a combination of structural biology and molecular simulations co-supervised by me, @marcvanderkamp and @AdrianMulholla1 ! gw4biomed.ac.uk/penicillin-ant…
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Dr. Catherine Tooke retweeted
#PhD opportunity for Sept 2024:
@GW4BioMedDTP project on overcoming Class C β-lactamase mediated #AntimicrobialResistance!
with @kcat_Tooke, @Spencer_D60, @AdrianMulholla1
Project: gw4biomed.ac.uk/overcoming-%ce…
DTP deadline Nov 1st
#BlackInChem particularly encouraged!
@GW4BioMedDTP project on overcoming Class C β-lactamase mediated #AntimicrobialResistance!
with @kcat_Tooke, @Spencer_D60, @AdrianMulholla1
Project: gw4biomed.ac.uk/overcoming-%ce…
DTP deadline Nov 1st
#BlackInChem particularly encouraged!
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Very excited to start as Prize Fellow in Antimicrobial Resistance at the University of Bath today! @LifeScienceBath.
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I had a great day at #ASMicrobe, some really interesting sessions and nice to present a poster on my KPC investigations ft. @Michaelbeer777 and @phil_hinchliffe from @Spencer_D60.
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Spectacular talk at the 14th annual beta-lactamase meeting by Prof. Robert Bonomo. Beautifully putting current clinical challenges in perspective and demonstrating the urgency and need for a continuous BL inhibitor pipeline
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Dr. Catherine Tooke retweeted
#pint23 is getting very close!
Science talks in relaxed atmosphere for 3 nights, come meet and chat with scientists! No science background needed.
🗓️22nd-24th May 2023
📍40 towns/cities across the UK
🗣️400 events
🐟🫀👩🔬👓📚🧠✨🧪🔭🥼🧫🦴
Book here 🎟️pintofscience.co.uk
Science talks in relaxed atmosphere for 3 nights, come meet and chat with scientists! No science background needed.
🗓️22nd-24th May 2023
📍40 towns/cities across the UK
🗣️400 events
🐟🫀👩🔬👓📚🧠✨🧪🔭🥼🧫🦴
Book here 🎟️pintofscience.co.uk
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Dr. Catherine Tooke retweeted
Latest paper from the lab, work of @Dora_Bonini with help from @alnaharialaa1 @SeanaDuggan Tarci and @HenrikStrahl
Where we decipher how the tiny and tricksy MspA protein controls S. aureus virulence in such a pleiotrophic manner. 1/2
biorxiv.org/content/10.110…
Where we decipher how the tiny and tricksy MspA protein controls S. aureus virulence in such a pleiotrophic manner. 1/2
biorxiv.org/content/10.110…
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Dr. Catherine Tooke retweeted
Fancy a pint? Join us in the pub for a pint (23rd May) where my colleagues and I will be giving talks at #pintofscience about the work we do on antibiotic resistance. Click the link for tickets and more info! #pintofscience #antibioticresistance #health
pintofscience.co.uk/event/microbes…
pintofscience.co.uk/event/microbes…
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Dr. Catherine Tooke retweeted
Happy to have contributed to this, out now in @J_A_C_S, examining what defines KPC-2 beta-lactamase’s activity! Together with @kcat_Tooke @phil_hinchliffe @AdrianMulholla1 @SchofieldOxford @Spencer_D60 @SWBio_DTP pubs.acs.org/doi/10.1021/ja…
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Dr. Catherine Tooke retweeted
Out now in preprint! Led by @kcat_Tooke we use high resolution crystallography and QM/MM umbrella sampling simulations to explain KPC-2’s broad spectrum, carbapenemase activity @SWBio_DTP @AdrianMulholla1 @Spencer_D60 @phil_hinchliffe @SchofieldOxford biorxiv.org/content/10.110…
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Our latest work detailing how omega-loop stability and carbapenem acyl-enzyme tautomerisation define activity of the KPC-2 beta-lactamase is out in pre-print. biorxiv.org/content/10.110…. @phil_hinchliffe @Michaelbeer777 @AdrianMulholla1 @Spencer_D60 @SchofieldOxford
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Thanks Jim, it was a fab lab day out!
First summer lab day out since the BeforeTimes- tour of @PenderynWhisky, a walk and a wild swim in the wonderful Brecon Beacons. Thanks to the group for a great day!
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Dr. Catherine Tooke retweeted
First paper for @SWBio_DTP @CMMBristol PhD student @Michaelbeer777 now out in #ACSID, harnessing QM/MM to unravel carbapenemase activity. Congratulations Michael #EwaChudyk @AdrianMulholla1 and @marcvanderkamp. pubs.acs.org/doi/10.1021/ac…
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Dr. Catherine Tooke retweeted
New paper on enmetazobactam interactions with CTX-M-15 extended spectrum beta-lactamase now out in mBio journals.asm.org/doi/10.1128/mb…. Kudos to @kcat_Tooke and @phil_hinchliffe for the heavy lifting @CMMBristol and huge thanks to #RobertBonomo and Cleveland team
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Dr. Catherine Tooke retweeted
3rd and Final Day of #BCA22 @britcryst with @DougInstruments - today was the room temperature data collection 💎 (serial/time-resolved) - some great talks including @kcat_Tooke studying AMR and beta-lactamases 💊 with SSX and SFX
@SoCoBioDtp @DiamondLightSou @sotonbiosci @amorv
@SoCoBioDtp @DiamondLightSou @sotonbiosci @amorv
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Dr. Catherine Tooke retweeted
Day 2 of #BCA22 @britcryst with @DougInstruments demonstrating the capabilities of the Oryx crystallisation robot 💎 - also some great talks on electron diffraction (ED) including @CourtneyLendon on producing microcrystals for ED @SoCoBioDtp @sotonbiosci @DiamondLightSou
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