Iron-Catalyzed Friedel–Crafts Reactions of Unactivated 3-Aryl-Oxetanols Exploiting HFIP Stabilization of Carbocations | The Journal of Organic Chemistry pubs.acs.org/doi/10.1021/ac…

We're currently recruiting for a Professor of Chemistry working in:

- Medicinal chemistry
- Novel molecular therapeutic modalities
- Chemical biology
- AI-enabled therapeutic discovery

Interested? Apply now: imperial.ac.uk/jobs/search-jo…

Do Amino-Oxetanes Resemble Amides? A Matched Molecular Pairs Property and Structural Comparison | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Our latest work on the synthesis of heterocyclic fragments out now:
Regio‐ and Stereocontrolled‐Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C‐H Arylation
doi.org/10.1002/chem.2…

Hodan and Sarah's work in collaboration with @jamesabull and Phil Miller on transforming trifluoromethane (HFC-23) into fluoroalkenes is now out in @angew_chem here is the link: onlinelibrary.wiley.com/doi/10.1002/an…

Do Amino-Oxetanes Resemble Amides?
Check out our Matched Molecular Pairs study in @ChemRxiv comparing properties and structure.
Congrats @hikaruishikura and coworkers, in collaboration with Pfizer.
doi.org/10.26434/chemr…

As asymmetric sulfur(VI) derivatives become more prevalent in the chemical sciences, especially in aza-derivatives, sulfoximines, sulfonimidamides, we have reviewed "The stereochemistry of substitution at S(VI)"
doi.org/10.1039/D5QO01…

Congrats to Freeman and Peerawat on our recent @ChemRxiv - Synthesis of Cyclic Sulfilimines and Sulfoximines via Copper Mediated C(sp2)–H Sulfanylation of Benzylamines with a Catalytic Transient Directing Group.
chemrxiv.org/engage/chemrxi…

Now published in ChemistryEurope: doi.org/10.1002/ceur.2…

Synthesis of Cyclic Sulfilimines and Sulfoximines via Copper-Mediated C(sp2)–H Sulfanylation of Benzylamines with a Catalytic Transient Directing Group by James A. Bull and co-workers (@jamesabull, @imperialcollege) #OpenAccess 🔓 onlinelibrary.wiley.com/doi/10.1002/ce…

New orthogonal SuFEx and SNAr reactivity of sulfonimidoyl fluorides and the automated synthesis of sulfonimidamides by @jamesabull and coworkers (@imperialcollege) #OpenAccess 🔓 onlinelibrary.wiley.com/doi/10.1002/ce…

Our work on the divergent synthesis of difluorocyclobutanes, now published in #JOC @JOC_OL.
Synthesis of gem-Difluorocyclobutanes: Organolanthanum Enabled Synthesis and Divergent Catalytic Functionalization of gem-Difluorocyclobutanols pubs.acs.org/doi/10.1021/ac…

SuFEx and SNAr on Sulfonimidoyl Fluorides - pleased this is now published in @ChemistryEur.
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ce…

Electrochemical Copper Catalysis: A Triple Catalytic System for Transient C(sp2)–H Functionalization Through Mediated Electrolysis | @ChemRxiv
Congrats Freeman @TszKanMa1
doi.org/10.26434/chemr…

Interested in strained rings or fluorine for medicinal chemistry - check out Hikaru’s work on divergent synthesis of difluorocyclobutanes, on ChemRxiv:
doi.org/10.26434/chemr…

Happy to report our work on catalytic SuFEx with sulfonimidoyl fluorides - and switchable SNAr reacts also. Congrats to Nikki on her paper now on ChemRxiv
doi.org/10.26434/chemr…

** New PhD position ** We are advertising a chemical biology studentship with Profs Vilar and Mann, in collaboration with GSK, with ICB CDT @icbcdt .
#automation, #Synthesis, #D2B.
Fully funded at UK fees level.
findaphd.com/phds/project/d…

Did you miss Ulrich Luecking’s talk about "Sulfoximines in Medicinal Chemistry: Unlocking Novel Opportunities in Drug Design"?

In this Flash Talk, Ulrich Luecking, VP and Head of Chemistry at FoRx Therapeutics, explores the untapped potential of sulfoximines in modern drug s several exciting development candidates on novel and established targets such as AZ's ATR inhibitor ceralasertib, Artios' ATR inhibitor ART0380, Tango's CoREST complex inhibitor TNG-260, and many more. Ulrich also showcases the use of sulfoximines beyond traditional small molecules and exemplifies innovative synthetic strategies for accessing them.

A standout moment in the talk was the first time disclosure of FORX-1589, a covalent WRN inhibitor featuring a novel vinyl sulfoximine warhead. The patent application containing this compound was just published last week.

The Flash Talk concluded with a lively Q&A where Ulrich answered many insightful audience questions. Watch the full Flash Talk on our YouTube channel now and don't forget to share it with a colleague who'd appreciate knowing more about the use of sulfoximines as an innovative functional group!

Watch Now: drughunters.com/42skhot

Last update of our "useful link" website: we added a few computational tools and compound databases useful for organic chemists! (Just a start, happy to add more in the future)

epfl.ch/labs/lcso/grou…

We are advertising a 2nd fully funded PhD studentship with @TateScience and @icbcdt for October -
New dimensions for covalent enantioprobe chemoproteomics
#chemicalbiology, #synthesis, #chemoproteomics, #CHfunctionalisation.
findaphd.com/phds/project/n…