Pinned Tweet
Excited to share our work on aspirin for primary prevention in ppl w/ elevated Lp(a) @JAHA_AHA @AHAScience
In a propensity matched cohort in MESA, aspirin was a/w a 46% reduction in CHD risk in ppl with Lp(a) >50 mg/dL.
A 🧵
@Lpa_Doc @UCSDCardiology
ahajournals.org/doi/10.1161/JA…
In a propensity matched cohort in MESA, aspirin was a/w a 46% reduction in CHD risk in ppl with Lp(a) >50 mg/dL.
A 🧵
@Lpa_Doc @UCSDCardiology
ahajournals.org/doi/10.1161/JA…
14
39
175
21,528
Harpreet Bhatia retweeted
🫀 Can coronary atherosclerosis actually regress?
Our new randomized FLOWPROMOTE trial analysis, published TODAY in JAMA Cardiology, shows remarkable coronary plaque regression with intensive LDL-C lowering!
Atherosclerosis is not necessarily a one-way process.
📄 JAMA o/a48M9gXtWl
#Atherosclerosis #LDL #Cardiology #CCTA
Our new randomized FLOWPROMOTE trial analysis, published TODAY in JAMA Cardiology, shows remarkable coronary plaque regression with intensive LDL-C lowering!
Atherosclerosis is not necessarily a one-way process.
📄 JAMA o/a48M9gXtWl
#Atherosclerosis #LDL #Cardiology #CCTA
81
369
1,367
252,910
Are we doing enough to lower LDL-C and Lp(a) risk in patients with ASCVD? Join me and Dr. Leslie Cho for a @PeerView live symposium at #ScientificSessions26 in Chicago, 11/7 at 6:30 AM CST, or online: bit.ly/26-LLT-T #Cardiology #MedEd
0
5
13
469
In our new @masala_study analysis @JACCJournals, Lp(a) levels vary among disaggregated South Asian groups, but the association between Lp(a) levels and outcomes does not.
@UCSDCardiology @UCSDCardFellows
sciencedirect.com/science/articl…
@UCSDCardiology @UCSDCardFellows
sciencedirect.com/science/articl…
3
22
77
5,307
Further studies of disaggregated South Asian groups are needed @alka_kanaya @PamTaubMD @MWilkinsonMD @MattRamsisMD @AKulkarniMD @DineshKalra
0
1
5
333
Harpreet Bhatia retweeted
Could your #cholesterol numbers be missing part of the picture? Harpreet Bhatia, MD, discusses advanced tests that can provide a more complete view of heart disease risk, including Lipoprotein(a), a largely inherited risk factor that often goes undetected. aarp.org/health/conditi…
0
2
6
531
We tested over 30 new ways of calculating a CAC score to incorporate the inverse association between plaque density and risk and develop CAC-VD. CAC-VD demonstrated improved performance over the Agatston score in MESA and an external validation cohort.
Can we improve on the Agatston score? 🫀 The new CAC Volume & Density (CAC-VD) score is simple to calculate, accounts for the inverse association of calcium density with CHD risk, & improves risk prediction vs the Agatston score @hsbhatia @UCSDCards
ahajrnls.org/3W1sT4v
1
6
23
1,277
Harpreet Bhatia retweeted
When statins aren't enough, what's next? Harpreet S. Bhatia, MD (@hsbhatia), discusses the role of PCSK9 inhibitors & other non-statin therapies in helping high-risk patients reach their lipid targets. New video activity now available: bit.ly/4dw5PRT #dyslipidemia
0
2
4
322
Harpreet Bhatia retweeted
Leading the Way to Better #Hyperlipidemia Care: Learn how to tailor lipid-lowering therapies for patients with ASCVD with Harpreet S. Bhatia, MD (@hsbhatia) and Leslie Cho, MD, on 11/7 at 6:30 AM CST: bit.ly/26-LLT-T
Thank you to our educational grant supporter @Novartis
#MedEd
Thank you to our educational grant supporter @Novartis
#MedEd
0
3
5
351
Harpreet Bhatia retweeted
#FHFSummit26
Session 2 of Day 2 of the @FamilyHeartFdn Global Summit kicks off with a great talk by @hsbhatia from @UCSDCardiology on Lp(a), post Horizon:
✅ Still a powerful risk enhancer for CVD
✅ Risk favor management reduces risk
✅ Screening still critical
#KnowLpa
Session 2 of Day 2 of the @FamilyHeartFdn Global Summit kicks off with a great talk by @hsbhatia from @UCSDCardiology on Lp(a), post Horizon:
✅ Still a powerful risk enhancer for CVD
✅ Risk favor management reduces risk
✅ Screening still critical
#KnowLpa
0
3
7
284
Harpreet Bhatia retweeted
How many meeting have astronauts, NFL players, clinical trialists, clinicians, and individuals with lived experience? #FamilyHeartSummit26 @FamilyHeartFdn
1
4
23
1,055
Is low Lp(a) associated with risk of diabetes? This new study @AJPCardio suggests it does not, based on a SNP associated with very low Lp(a) levels.
sciencedirect.com/science/articl…
Editorial by @IzzaShahid_ and I for context, including reverse confounding: sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
Editorial by @IzzaShahid_ and I for context, including reverse confounding: sciencedirect.com/science/articl…
1
3
13
957
In this commentary, @DrNathanWong and I review potential explanations for the negative topline results for HORIZON but emphasize that this does not mean Lp(a) testing is not needed.
@AJPCardio @ASPCardio @FamilyHeartFdn @UCSDCardiology @UCSDCardFellows
sciencedirect.com/science/articl…
@AJPCardio @ASPCardio @FamilyHeartFdn @UCSDCardiology @UCSDCardFellows
sciencedirect.com/science/articl…
2
10
30
3,217
It remains unchanged that Lp(a) is a well established risk factor for CVD and knowledge of Lp(a) levels helps to better understand personalized risk and can drive more aggressive risk factor management.
1
0
3
280
CAC can be effective for risk stratifying individuals with elevated Lp(a). In this study, we ask when to start CAC scoring and when repeat scoring should be considered.
@KhedagiApurva @AlexRazavi @rblument1 @MichaelJBlaha @OmarDzaye @AJPCardio @ASPCardio
doi.org/10.1016/j.ajpc…
@KhedagiApurva @AlexRazavi @rblument1 @MichaelJBlaha @OmarDzaye @AJPCardio @ASPCardio
doi.org/10.1016/j.ajpc…
5
15
43
6,889
I laugh because you obviously read the paper which talks primarily about the association of Lp(a) with atherosclerosis in multiple vascular beds, the potential role for CAC, and the uncertain role of CCTA and carotid US. Thanks for taking it so seriously :)
Glad to entertain you, I guess!
However, seasoned doctors have all seen the harms of low value testing cascades and take these things more somberly
Great essay I just linked in my feed talking exactly about these harms
0
0
10
10,440
Lp(a) and subclinical atherosclerosis: our new review of the association between Lp(a) and subclinical atherosclerosis, and the use of imaging for risk stratifying individuals with elevated Lp(a).
sciencedirect.com/science/articl…
@KhedagiApurva @yusi_gong @dharmajrmd @LipidJournal
sciencedirect.com/science/articl…
@KhedagiApurva @yusi_gong @dharmajrmd @LipidJournal
9
30
117
23,872