June retweeted
Core biopsy done for 1 cm mass in 65/F with and clinical impression is papilloma. How should we sign this case out? #breastpath
1
7
44
2,791
June retweeted
Secretory carcinoma of the breast is a rare (<0.2%) low-grade triple-negative carcinoma defined by the ETV6::NTRK3 fusion.
🔬 Key clues: bubbly eosinophilic secretions, S100+, ER/PR/HER2−, and PAN-TRK positivity.
Remarkably, it occurs from childhood to older age. #breastpath
🔬 Key clues: bubbly eosinophilic secretions, S100+, ER/PR/HER2−, and PAN-TRK positivity.
Remarkably, it occurs from childhood to older age. #breastpath
1
15
61
1,632
June retweeted
Stereotactic biopsy for calcs in a 48F: The eternal dilemma. Call DCIS -> surgery/radiation. Call LCIS -> observation. Sign it out right. but How? Aberrant E-Cadherin or real? #Pathology #BreastPath
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2,787
June retweeted
Treated synovial sarcoma with extensive epithelial differentiation metastatic to a lymph node, mimicking carcinoma. #BSTPath
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154
10,819
June retweeted
Multiple B/L 🫁nodules in a young woman.
Classic histology of epithelioid hemangioendothelioma(EHE) in the lung.
One of those diagnoses that is easy when you know the morphology, but can be a real diagnostic challenge when you don’t.
#PathTwitter #MedTwitter #LungPath
Classic histology of epithelioid hemangioendothelioma(EHE) in the lung.
One of those diagnoses that is easy when you know the morphology, but can be a real diagnostic challenge when you don’t.
#PathTwitter #MedTwitter #LungPath
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3,539
June retweeted
WHAT'S NEW IN COLORECTAL TUMORS (WHO 6TH EDITION 2026)
What defines high grade in adenocarcinoma?
At least one focus lacking gland formation (40x-high power field)
Dr. Srivastava GIPS pathcast youtube.com/live/mdt3Pr4G1… #pathology #PathX #PathTwitter
What defines high grade in adenocarcinoma?
At least one focus lacking gland formation (40x-high power field)
Dr. Srivastava GIPS pathcast youtube.com/live/mdt3Pr4G1… #pathology #PathX #PathTwitter
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4,115
June retweeted
WHAT'S NEW IN NEUROENDOCRINE TUMORS (WHO 6TH EDITION 2026)
Assess presence/abscence of necrosis: Not all necrosis are equal
-Single cell/comedo: NET
-Infarct type: Seen in setting of prior biopsy/embolization
-Geographic: NEC
Dr. Bellizzi GIPS pathcast youtube.com/live/o8IqIDiN_… #pathology #PathX
Assess presence/abscence of necrosis: Not all necrosis are equal
-Single cell/comedo: NET
-Infarct type: Seen in setting of prior biopsy/embolization
-Geographic: NEC
Dr. Bellizzi GIPS pathcast youtube.com/live/o8IqIDiN_… #pathology #PathX
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41
78
3,658
June retweeted
IASLC expert panel proposes an updated pulmonary carcinoid/NET classification ( Expected to be included into the forthcoming WHO thoracic blue book)
1. Keep “carcinoid” as the main diagnostic term for thoracic clinicians, while moving toward the “NET” nomenclature used in other a diagnostic criterion. 5% threshold is pulmonary specific
3. Formally recognize rare carcinoid/NET G3 tumors (higher proliferation, but molecularly closer to NETs than to high-grade NECs)
More on jto.org/article/S1556-…
Slides below from Dr. Bellizzi’s presentation: What’s New in Neuroendocrine Tumors (WHO 6th Edition, 2026)
youtube.com/live/o8IqIDiN_… #pathology #pathX
1. Keep “carcinoid” as the main diagnostic term for thoracic clinicians, while moving toward the “NET” nomenclature used in other a diagnostic criterion. 5% threshold is pulmonary specific
3. Formally recognize rare carcinoid/NET G3 tumors (higher proliferation, but molecularly closer to NETs than to high-grade NECs)
More on jto.org/article/S1556-…
Slides below from Dr. Bellizzi’s presentation: What’s New in Neuroendocrine Tumors (WHO 6th Edition, 2026)
youtube.com/live/o8IqIDiN_… #pathology #pathX
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6,409
June retweeted
Temporal artery biopsy referred to me as a possible periarteritis. I was struck by the perineural inflammation but on deeper levels and pictured AE1/3 the answer was revealed.....
not mentioned in the history but in the EPR patient had a scalp PDKSCC excised 4 years earlier!
not mentioned in the history but in the EPR patient had a scalp PDKSCC excised 4 years earlier!
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63
3,106
June retweeted
Another classic "KIT"fall - metastatic melanoma presenting as a gastric polyp. Melanomas often express KIT/CD117.
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50
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4,255
June retweeted
Sclerosing adenosis and fibrocystic changes can have foci of squamous metaplasia
⚠️ Pitfall: Overinterpreting this as carcinoma, especially in biopsies
Dr. Calhoun #USCAP #BreastPath #pathology #PathX
⚠️ Pitfall: Overinterpreting this as carcinoma, especially in biopsies
Dr. Calhoun #USCAP #BreastPath #pathology #PathX
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27
87
3,357
June retweeted
Happy Friday, everyone. Here's a cool case to think about over the weekend (yeah right😀)
Central duct excision for bloody nipple discharge. No previous biopsy.
What is your diagnosis?
#breastpath
Central duct excision for bloody nipple discharge. No previous biopsy.
What is your diagnosis?
#breastpath
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22
52
4,132
June retweeted
Staging scan for sigmoid adenocarcinoma picks up this inguinal nodal mass which was biopsied, what is your diagnosis and what IHC would you perform if any? pathologyoutlines.com/caseofweek/cas…
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18
63
3,210
June retweeted
Updates from the WHO Classification of Breast Tumors, 6th Edition (not published yet)
Invasive lobular carcinoma with extracellular mucin
- Recently described
- Needs to be separated from classic ILC and mucinous carcinoma in view of more aggressive biological behavior and less . Tan #USCAP #pathology #PathX #PathTwitter
Invasive lobular carcinoma with extracellular mucin
- Recently described
- Needs to be separated from classic ILC and mucinous carcinoma in view of more aggressive biological behavior and less . Tan #USCAP #pathology #PathX #PathTwitter
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32
87
4,029
June retweeted
Unusual breast lesions
Secretory carcinoma
Almost all secretory carcinomas harbor ETV6-NTRK3
translocations and FISH for ETV6 is a useful ancillary study to confirm the diagnosis
Secretory carcinoma is a subset of triple-negative breast cancers with a favorable prognosis. udies have reported instances of recurrence and metastasis
Dr. Calhoun #USCAP #pathology #PathX #pathtwitter
Secretory carcinoma
Almost all secretory carcinomas harbor ETV6-NTRK3
translocations and FISH for ETV6 is a useful ancillary study to confirm the diagnosis
Secretory carcinoma is a subset of triple-negative breast cancers with a favorable prognosis. udies have reported instances of recurrence and metastasis
Dr. Calhoun #USCAP #pathology #PathX #pathtwitter
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23
69
2,906
June retweeted
Updates from the WHO Classification of Breast Tumors, 6th Edition (not published yet)
The WHO 5th edition recommended that encapsulated papillary carcinoma (EPC) with high nuclear grade, increased mitotic activity, and/or a triple-negative or HER2-positive phenotype be graded, invasive disease
In the 6th edition, the WHO now recognizes the existence of rare forms of EPC with high-grade features or ER negativity that may still be categorized as EPC
Such tumors may be encountered on core biopsy; classifying them as invasive could lead to inadvertent neoadjuvant therapy
The vast majority of EPCs should be low- to intermediate-nuclear grade and ER-positive
Dr. Tan #USCAP #pathology #PathX #PathTwitter
The WHO 5th edition recommended that encapsulated papillary carcinoma (EPC) with high nuclear grade, increased mitotic activity, and/or a triple-negative or HER2-positive phenotype be graded, invasive disease
In the 6th edition, the WHO now recognizes the existence of rare forms of EPC with high-grade features or ER negativity that may still be categorized as EPC
Such tumors may be encountered on core biopsy; classifying them as invasive could lead to inadvertent neoadjuvant therapy
The vast majority of EPCs should be low- to intermediate-nuclear grade and ER-positive
Dr. Tan #USCAP #pathology #PathX #PathTwitter
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3,598
