Proper organelle regulation during mitosis is a must, but how do membrane-less condensates like PML bodies behave during cell division? In work led by @eric_aird, we found the balance of speckled proteins SP110 & SP100 to be the key. doi.org/10.1038/s41556…

Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using #CRISPR screening, we show ERCC6L2 is specifically required to maintain #DNArepair fidelity at staggered DNA breaks, but not at blunt ends.
nature.com/articles/s4146…

Amazing postdoc Eric Aird asked how #CRISPR gRNAs & interferon regulate innate #immunity. He found a wild partnership that balances appropriate response w/ cell death. SP100 builds filaments that kill cells, and SP110 breaks them to keep things in line. biorxiv.org/content/10.110… 🧵

Today in @biorxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with @connorjtou. A 🧵 (1/14):
biorxiv.org/content/10.110…

WORLD CRISPR DAY is back!
We'd love for you to join us at @Synthego's amazing, virtual, free scientific symposium that brings together genome engineering scientists, clinicians, and thought leaders from around the world!

Please register for free at worldcrisprday.com

The @jcornlab reports on Recursive Editing, a way to drive high levels of #CRISPR-mediated precise genomic modification without manipulating cell factors or state. An accompanying easy-to-use software designs experiments to optimize target selection. biol.ethz.ch/en/news-and-ev…

The latest #CRISPR-​based genome editing systems are safer for patients who will soon benefit from gene therapies, as @eric_aird explains in the latest #ZukunftsBlog @ETH_en @ETH_DBIOL #GenomeEditing
ethz.ch/en/news-and-ev…