✨Our 100th issue!🎉

The October issue is now online featuring #HuntingtonsDisease, #RSV, #AI in trials, #CardiacArrest, #PTSD, #OSA, and more with our editorial on dangers of data shortages

…all available #OpenAccess❗️

Read here: thelancet.com/issue/S2589-53…

Attribution: Getty

CT-based AI risk support for cystic renal masses: multicenter validation, reader study, and a randomized implementation study

KITE-CRM improved assisted interpretation and reporting efficiency

thelancet.com/journals/eclin…

Sepsis-related hospitalisation risk in #preterm-born and term-born children and adolescents: a nationwide registry study

Lower #gestational age was associated with an increased risk of #sepsis-related hospitalisation throughout childhood and adolescence

thelancet.com/journals/eclin…

Efficacy and safety of #duloxetine for #osteoarthritis: a comparator-stratified systematic review and meta-analysis

Duloxetine was associated with improvements in pain and physical function in osteoarthritis, with clearest benefit observed versus placebo

thelancet.com/journals/eclin…

Single-dose/day vs extended antibiotic prophylaxis for elective #UrologicalSurgery: a prospective RCT

There was no statistically significant difference in postoperative symptomatic #UTI incidence between single-dose and extended antibiotic prophylaxis

thelancet.com/journals/eclin…

A new study that our lab contributed to has been published in @eClinicalMed
Predicting PANSS symptoms in schizophrenia spectrum disorders using speech only: an international, multi-centre, computational secondary analysis across multiple languages
sciencedirect.com/science/articl…

Efficacy and safety of #IntrathecalChemotherapy in #LeptomeningealDisease: a global retrospective multicenter analysis and literaturereview

Provides important insights into the role of ITC in both solid and hematologic malignancies

thelancet.com/journals/eclin…

Please read our open access new paper in The Lancet @eClinicalMed

Efficacy and safety of intrathecal chemotherapy in leptomeningeal disease: a global retrospective multicenter analysis"
🔗 doi.org/10.1016/j.ecli…

Sex and disease differences in patients’ diagnostic experiences in #AutoimmuneDiseases: an international cross-sectional study

Females with autoimmune diseases reported more challenging diagnostic journeys than males

thelancet.com/journals/eclin…

🚨 KEYNOTE-966 ~3-Yr Update: #Pembrolizumab + gem/cis maintains a sustained survival benefit in advanced #BTC. @eClinicalMed
👉 OS: Median 12.7 vs 10.9 mos (HR 0.86).
👉 DoR: Median 8.3 vs 6.9 mos.
👉 Safety: No new safety signals observed.
DOI: doi.org/10.1016/j.ecli…
@ILCAnews

Drug-Coated Balloons vs Drug-Eluting Stents: What Does the Evidence Show?

Our new meta-analysis of 10 RCTs (7,832 patients) led by @CorballisTash

@TheLancet @eClinicalMed

No difference in cardiovascular death or MI. But revasc may be higher.

thelancet.com/journals/eclin…

@NNUH

The effects of the arts and #ArtsTherapies on #MentalHealth outcomes of children and young people: an SRMA

Average effects were similar to those typically reported for established non-arts-based psychosocial interventions, including talking therapies

thelancet.com/journals/eclin…

🧬 KEYNOTE-966 | Advanced BTC | ~3-year follow-up

👥 1,069 pts
💊 Pembrolizumab + gem/cis vs placebo + gem/cis
📈 OS HR 0.86
📊 3-y OS 13% vs 11%
🛡️ G3–4 TRAEs 70% vs 69%
✅ Survival benefit maintained with no new safety signals

🔗 doi.org/10.1016/j.ecli…

@OncoAlert

Efficacy and safety of temporary selective portal vein embolization before major #hepatectomy: phase 2 trial

Temporary PVE using an absorbable embolic agent is feasible, safe, and capable of inducing clinically meaningful liver hypertrophy

thelancet.com/journals/eclin…

Generalisability of an adult-trained AI model to paediatric coeliac disease diagnosis: multicentre external validation study

Our AI model, trained on adult biopsies, generalises to paediatric #CoeliacDisease diagnosis across centres and scanner platforms

thelancet.com/journals/eclin…

Safety and tolerability of elinzanetant: pooled analysis from four RCTs

The overall safety profile of #elinzanetant appeared favorable in 1113 women with vasomotor symptoms (VMS) associated with #menopause based on this exploratory pooled safety analysis

thelancet.com/journals/eclin…

Chronic pelvic and related genital #pain in #transgender and gender-diverse people: a scoping review

Supports gender-affirming MDT evaluation while highlighting need for standardised CPP definitions and validated TGD-specific patient-reported measures

thelancet.com/journals/eclin…

New Lancet Series: the way digital technologies are built & governed creates real health risks worldwide. A review of 9 million under-25s across 121 studies links digital media use to mental health & sleep problems plus reduced physical activity. Authors call for urgent, coordina/t.co/5CwG2nBh4f

Monoclonal gammopathy of undetermined significance (#MGUS) in Black individuals in Soweto, South Africa screened by mass spectrometry: PROMISE study

Suggests Black South Africans represent a high-risk population with increased likelihood of having MGUS

thelancet.com/journals/eclin…

Congrats Claudio Vernieri and team 🇮🇹

Prognostic value of HR expression in patients with HR+/HER2− advanced #breastcancer treated with first-line ET+CDK4/6i: results from PALMARES-2 study @eClinicalMed

@OncoAlert #OncoAlert
thelancet.com/journals/eclin…